Results 41 to 50 of about 17,056 (307)
FEBS Letters, EarlyView.Structural and biochemical characterisations show that the planar cell polarity (PCP) protein Inturned harbours a unique PDZ‐like domain that does not bind canonical PDZ‐binding motifs (PBMs) like that of another PCP protein Vangl2. In contrast, the apical‐basal polarity protein Scribble contains four PDZ domains that bind Vangl2, but one PDZ domain ...
Stephan Wilmes +4 more
wiley +1 more source
Structural insights into an engineered feruloyl esterase with improved MHET degrading properties
FEBS Letters, EarlyView.A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa +5 more
wiley +1 more source
«Cannibale»’s Translations and the Reception of US Underground Comix in Italy
Ticontre: Teoria Testo Traduzione, 2022 By relying on the tools provided by semiotics (in particular, isotopic and thymic analysis) and multimodality, this paper presents a contrastive analysis of the Italian translations of a selection of works belonging to the US underground comix ...
Chiara Polli
doaj +1 more source
Nick Clegg’s rise and fall as a celebrity politician highlights the Deputy Prime Minister as a victim of the increasing personification of British politics [PDF]
, 2011 Nick Clegg has occupied a significant place in the popular imagination of the British public since the General Election of 2010. The extraordinary character of politics has shone a more intense light on the Liberal Democrat party with its leader standing
Parry, Katy, Richardson, Kay
core
FEBS Letters, EarlyView.This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel +13 more
wiley +1 more source
Molecular Oncology, EarlyView.Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee +8 more
wiley +1 more source
Cogent Arts & Humanities, 2023 This paper exercises a multimodal discourse analysis approach to explore the visual representation(s) of Saudi women in a small cartoon corpus published on a global online platform, Cartoon Movement.
Afnan Alasmari, Alaa Almohammadi
doaj +1 more source
The interaction of cartoonist's gender and formal features of cartoons [PDF]
, 2017 The present study investigates gender differences in the use of formal features of cartoons, like the amount of text, the number of panels, or the application of color.
Huber, Oswald, Samson, Andrea C.
core
Molecular Oncology, EarlyView.Here, we demonstrate that HS1BP3 interacts with Cortactin through a proline‐rich region (PRR3.1) and show that this interaction, and HS1BP3 itself, promote cancer cell proliferation and invasion. Inhibition of this interaction leads to build‐up of TKS5 in multivesicular endosomes and altered secretion of CD63 and CD9, providing an explanation for the ...
Arja Arnesen Løchen +9 more
wiley +1 more source
Humor gráfico en la web. Aproximación descriptiva a los dibujantes de la ciber prensa en Euskadi
Sancho el Sabio, 2020 El presente artículo pretende un análisis descriptivo de la localización y visualidad otorgada al humor gráfico por parte de los diarios digitales vascos de mayor alcance y difusión.
Aitor Castañeda Zumeta
doaj +1 more source