Results 81 to 90 of about 425 (241)
Advanced Science, EarlyView.In pancreatic ductal adenocarcinoma (PDAC), insulin is associated with activation of PI3K/AKT–RAB3A signaling and enhanced secretion of TNFAIP8‐enriched exosomes from tumor cells. Uptake of these exosomes by fibroblasts is linked to TRIM21‐dependent STAT1 degradation and the emergence of myofibroblastic CAF–associated features, accompanied by increased
Zhenyu Li +15 more
wiley +1 more source
Lipid‐Facilitated Opening of the ADAM10 Sheddase Revealed by Enhanced Sampling Simulations
Advanced Science, EarlyView.Phosphatidylserine acts as a lipid trigger to enhance activation of the sheddase ADAM10. By integrating fluorescence spectroscopy assays with enhanced sampling molecular dynamics simulations, this study shows that phosphatidylserine promotes ADAM10 catalytic activity along with expansion of its extracellular domains, enhancing accessibility to scaffold
Adrien Schahl +7 more
wiley +1 more source
Storia delle Donne, 2023 According to the Western tradition, a “great divide” separates human beings from non-human animals. Such a boundary underlies the anthropocentric interpretation of the world and the power system that ecofeminists call ‘anthroparchy’.
Elena dell’Agnese
doaj
Human-centred design bolsters vaccine confidence in the Philippines: results of a randomised controlled trial. [PDF]
BMJ Glob Health, 2023 Reñosa MDC +14 more
europepmc +1 more source
Connexin43 Deficiency Leads to Ventricular Arrhythmias by Reprogramming Proline Metabolism
Advanced Science, EarlyView.The study demonstrated that connexin43 (Cx43) knockout caused arrhythmic phenotype and decreased proline content in vitro and in vivo. Mechanistically, Cx43 interacts with the amino acid transporter SNAT2 (sodium‐dependent neutral amino acid transporter), and its deficiency disrupts proline transport and metabolism.
Hangying Ying +8 more
wiley +1 more source
Advanced Science, EarlyView.Advanced clear cell renal cell carcinoma metastasis is driven by a FOXC2+ tumor subpopulation. These cells execute vasculogenic mimicry for dissemination and secrete LAMA4. LAMA4 engages macrophage ITGA6, activating the STAT6/GATA3 axis to polarize macrophages into a pro‐metastatic, immunosuppressive phenotype.
Jiaxi Yao +11 more
wiley +1 more source
Generating Dynamic Structures Through Physics‐Based Sampling of Predicted Inter‐Residue Geometries
Advanced Science, EarlyView.While static structure prediction has been revolutionized, modeling protein dynamics remains elusive. trRosettaX2‐Dynamics is presented to address this challenge. This framework leverages a Transformer‐based network to predict inter‐residue geometric constraints, guiding conformation generation via physics‐based iterative sampling. The resulting method
Chenxiao Xiang +3 more
wiley +1 more source
Visual Rhetoric in Mediating Impartial Humor: Political Cartoons on the Russo-Ukrainian War
Open Library of HumanitiesThis study investigates the intersection of visual rhetoric and impartial humor in political cartoons portraying the Russo-Ukrainian War. Drawing on foundational works on visual rhetoric, the paper situates political cartoons within the broader context ...
doaj +2 more sources
“Io so che l’intenzion lor fu onesta”. L’“Inferno” in Topolino [PDF]
Parole Rubate, 2019 Highlighting the importance of Italian comics in the years after the Second World War, this essay focuses on the graphic, linguistic, and figurative adaptations of Dante’s Inferno in the pages of the Italian comic par excellence, “Topolino” (Mickey Mouse)
Debora Barattin
doaj
Advanced Science, EarlyView.This study developed a novel drug delivery platform that overcomes the blood‐brain barrier in glioblastoma. By fusing IGFBP7 with small extracellular vesicles, the platform specifically targets tumor vasculature. It effectively delivers temozolomide, suppressing tumor growth at low doses.
Lingling Liu +17 more
wiley +1 more source