Results 271 to 280 of about 44,151 (306)
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Myocardial Protection with Carvedilol
Journal of Cardiovascular Pharmacology, 1992Carvedilol is a multiple-action cardiovascular agent that is both a beta-adrenoceptor antagonist and a vasodilator and has recently been made available for the treatment of mild-to-moderate hypertension. Clinical trials are ongoing to establish the efficacy of carvedilol in angina and congestive heart failure. beta-Adrenoceptor antagonists are known to
Steven A. Hamburger +4 more
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American Journal of Cardiovascular Drugs, 2008
▴ A new once-daily controlled-release (CR) capsule formulation of the nonselective β- and α1-adrenoceptor antagonist carvedilol is now available for use in the treatment of essential hypertension, heart failure (HF), and left ventricular dysfunction following myocardial infarction (MI).
Natalie J. Carter, Gillian M. Keating
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▴ A new once-daily controlled-release (CR) capsule formulation of the nonselective β- and α1-adrenoceptor antagonist carvedilol is now available for use in the treatment of essential hypertension, heart failure (HF), and left ventricular dysfunction following myocardial infarction (MI).
Natalie J. Carter, Gillian M. Keating
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American Journal of Gastroenterology, 2020
INTRODUCTION Beta-blockers are the mainstay agents for portal pressure reduction and to modestly reduce hepatic venous pressure gradient (HVPG). We studied whether addition of simvastatin to carvedilol in cirrhotic patients for primary prophylaxis ...
R. Vijayaraghavan +5 more
semanticscholar +1 more source
INTRODUCTION Beta-blockers are the mainstay agents for portal pressure reduction and to modestly reduce hepatic venous pressure gradient (HVPG). We studied whether addition of simvastatin to carvedilol in cirrhotic patients for primary prophylaxis ...
R. Vijayaraghavan +5 more
semanticscholar +1 more source
Study on fluorescence property of carvedilol and determination of carvedilol by fluorimetry
Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy, 2005The property of carvedilol in acid-alkaline medium was studied by spectrofluorimetry. Effects of organic solvents on carvedilol fluorescence spectra were examined and the reason was discussed. A simple, rapid and high sensitive fluorimetric method for the determination of carvedilol in medicine is developed.
Ni Hui +3 more
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Vasodilatory Action of Carvedilol
Journal of Cardiovascular Pharmacology, 1992Carvedilol is a dual-acting drug designed to produce two complementary effects: beta-blockade and vasodilation. These effects are induced in the same dose range, a prerequisite for utilizing both properties in an appropriate manner. The vasodilation is mediated predominantly by specific alpha 1-adrenoceptor blockade.
K. Strein +3 more
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The Clinical Investigator, 1992
Antihypertensive drugs have differing effects on renal hemodynamics, tubular function, plasma electrolytes, and hormonal responses. Nonselective beta-blockers without intrinsic sympathomimetic activities, such as propranolol, have been reported to reduce renal blood flow and to cause a modest decrease in glomerular filtration rate.
openaire +4 more sources
Antihypertensive drugs have differing effects on renal hemodynamics, tubular function, plasma electrolytes, and hormonal responses. Nonselective beta-blockers without intrinsic sympathomimetic activities, such as propranolol, have been reported to reduce renal blood flow and to cause a modest decrease in glomerular filtration rate.
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Antihypertensive profile of carvedilol
The Clinical Investigator, 1992The spectrum of demands on an antihypertensive agent is constantly increasing. It is not only supposed to reduce blood pressure, but also to have a certain profile with regard to pathophysiology, hemodynamics, pharmacokinetics, safety, and clinical applicability.
B Agrawal, W Meyer-Sabellek
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Metabolism of carvedilol in man
European Journal of Drug Metabolism and Pharmacokinetics, 1991The metabolism of carvedilol was investigated in plasma and urine of 3 healthy male volunteers after administration of 50 mg of [14C]-labelled drug. Rapid and extensive biotransformation occurred. After 1.5 h 9% of total radioactivity in plasma consisted of unchanged drug, 22% of carvedilol-glucuronide and another 20% of oxidative cleavage products of ...
G Neugebauer, P Neubert
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Journal of Cardiovascular Pharmacology and Therapeutics, 2020
Background: Insulin resistance (IR) is a well-known risk factor for cardiovascular complications. This study aimed to investigate the effect of a dietary model of IR in mice on cardiac remodeling, cardiac β-arrestin2 signaling, and the protective effects
W. Ibrahim +3 more
semanticscholar +1 more source
Background: Insulin resistance (IR) is a well-known risk factor for cardiovascular complications. This study aimed to investigate the effect of a dietary model of IR in mice on cardiac remodeling, cardiac β-arrestin2 signaling, and the protective effects
W. Ibrahim +3 more
semanticscholar +1 more source
Clinical and Experimental Pharmacology and Physiology, 2020
Cyclosporine is an immunosuppressive agent that is used to prevent organ rejection after organ transplantation. Due to the widespread use of this type of surgery, the effect of cyclosporine on reproduction and fertility should have a specific interest ...
Ahmed M. Kabel +3 more
semanticscholar +1 more source
Cyclosporine is an immunosuppressive agent that is used to prevent organ rejection after organ transplantation. Due to the widespread use of this type of surgery, the effect of cyclosporine on reproduction and fertility should have a specific interest ...
Ahmed M. Kabel +3 more
semanticscholar +1 more source