Results 151 to 160 of about 2,706,420 (286)

Nickel‐Catalyzed Three‐Component Difluoroalkylation‐Amination for the Direct Access to Anti‐Inflammatory β‐Difluoroalkyl Amines

Advanced Science, EarlyView.
A nickel‐catalyzed three‐component reductive fluoroalkylation‐amination strategy of N‐vinylamides for the direct access to the α‐amidyl‐β‐difluoroalkyl amines was reported here. The synthetic method features with broad substrate scope, mild conditions, high functional group tolerance, and convenience to handle.
Chang Xu, Fangting Ma, Fan Ding, Luyan Wang, Yunxi Li, Yunzhi He, Xingang Zhang, Siyu He, Dandan Liu   +8 more
wiley   +1 more source

A modular in vitro multienzyme cascade for the sustainable synthesis of high-value vidarabine 5'-monophosphate from adenosine. [PDF]

Synth Syst Biotechnol
Su W, Zhang X, Li R, Li K, Guo X, Liu X, Wang Z, Wang H, Liu Y.   +8 more
europepmc   +1 more source

Spatially Encoded Protocell Network for Non‐Cascaded Parallel Biocomputation

Advanced Science, EarlyView.
A non‐cascaded, hydrogel‐based proteinosome computational platform is developed, in which redox‐responsive proteinosomes serve as local computing units within a shared reaction–diffusion field. Reductant inputs, countered by an auxiliary glucose gradient, regulate spatially patterned proteinosome disruption, and generate population‐level boundaries ...
Shuqi Wu, Liangfei Tian
wiley   +1 more source

Chemo-Enzymatic Synthesis of Biomass-Derived Cationic Amino-Ester Surfactants. [PDF]

ChemSusChem
Carceller JM, Moriana C, Climent MJ, Iborra S, Corma A.   +4 more
europepmc   +1 more source

Biochemically Constrained Multi‐Omics Integration Reveals Protein–Metabolite Dependencies Across Diseases

Advanced Science, EarlyView.
ProMetNet introduces a biologically constrained deep learning framework for proteo‐metabolomic integration by embedding Reactome‐derived pathway topology into neural networks. It captures non‐linear molecular dependencies and pathway‐level metabolic reorganization, enabling interpretable discrimination.
Minghui Zhao, Na Zhou, Ruotong Liu, Xiaofei Li, Jian Li, Fuzhong Xue, Qingzhen Hou   +6 more
wiley   +1 more source

Biocatalytic Cascade from Geraniol to Enantiopure (R)-Citronellal Using an Aryl-Alcohol Oxidase and Ene Reductase. [PDF]

Org Lett
Ferrer-Carbonell C, Ascaso-Alegre C, Cinca-Fernando P, Ferreira P, Mangas-Sánchez J, Paul CE.   +5 more
europepmc   +1 more source

Blood Cell‐Camouflaged Liquid Metal Nanoconjugates Orchestrate Treg Depletion and STING‐Amplified Photothermal Immunity for Metastatic Triple‐Negative Breast Cancer Therapy

Advanced Science, EarlyView.
Whole‐blood biomimetic engineering transforms liquid metal nanoparticles into a tripartite immunotherapeutic platform that orchestrates regulatory T‐cell depletion, photothermal‐induced immunogenic cell death, and activation of the stimulator of interferon genes pathway.
Nina Sang, Eijiro Miyako
wiley   +1 more source

Sustainable Biocatalytic Cascades: A Versatile Tool in the Synthesis of Natural Products With Therapeutic Potential. [PDF]

Chembiochem
Yadav RN, Dey S, Pandey SK, Barman A, Hossain MF, Schmidt LC, Singh V.   +6 more
europepmc   +1 more source

Machine Learning‐Driven Design of Multicomponent Bone Inorganic Matrix Mimicking Scaffolds for Osteogenesis Enhanced by Neurogenesis

Advanced Science, EarlyView.
Schematic illustration of development of experimental datasets and algorithm models, screening and preparation of the scaffolds and their applications in vivo. ABSTRACT Bone defects require materials with osteogenic, neurogenic, and angiogenic activity, yet designing such materials within high‐dimensional compositional spaces remains challenging. Here,
Kunlu Lin, Ying Yang, Chuyao Zhou, Hanyue Mao, Zhiquan Zhang, Libangxi Liu, Xiaoying Yu, Haoming Liu, Long Liu, Xiaoyan Wang   +9 more
wiley   +1 more source

A tailored CoA ligase-<i>N</i>-acyltransferase cascade for on-DNA amide bond formation gives access to broad substrate scope. [PDF]

Nat Catal
Schaub D, Lessing A, Meyer F, Stockinger P, Estévez-Gay M, Eichenberger M, von Haugwitz G, Gloger A, Scheuermann J, Buller R.   +9 more
europepmc   +1 more source