Results 51 to 60 of about 98,441 (260)

The VHL tumor suppressor at the crossroad of protein folding, aggregation, and cancer

Molecular Oncology, EarlyView.
Mutations, environmental stress, and chaperone dysfunction can destabilize pVHL, promoting its conversion from the native folded state into amyloid‐like assemblies. This transition may contribute to protein storage, cell dormancy, survival, and drug resistance.
Lara Abad, Silvio Carlo Ermanno Tosatto, Emanuela Leonardi   +2 more
wiley   +1 more source

Graph-Conditioned Stochastic Modeling of Twitter Information Cascades with Dual-Head Transformers for Early Virality Prediction

Mathematics
Information cascades in online social networks arise from stochastic interactions among user behavior, temporal activation, and graph-structured exposure.
Bowen Dong, Xinyu Zhang, Chaoya Yan, Weiyan Zhu, Lingmin Hou, Yifan Feng   +5 more
doaj   +1 more source

Humidified and Heated Cascade Impactor for Aerosol Sizing

Frontiers in Bioengineering and Biotechnology, 2020
Aerosol sizing is generally measured at ambient air but human airways have different temperature (37°C) and relative humidity (100%) which can affect particle size in airways and consequently deposition prediction. This work aimed to develop and evaluate
Caroline Majoral, Caroline Majoral, Allan L. Coates, Alain Le Pape, Alain Le Pape, Laurent Vecellio, Laurent Vecellio   +6 more
doaj   +1 more source

INTEGRATING CLINICAL AND BLOOD COUNT DATA INTO A HYBRID MODEL TO PREDICT THROMBIN PROFILES AND VENOUS THROMBOEMBOLISM RISK

Hematology, Transfusion and Cell Therapy, 2023
Background: Mathematical models play a crucial role in comprehending the intricate interactions and cascade reactions of chemical species involved in the blood coagulation cascade. Accurate models facilitate the prediction of thrombin profiles, aiding in
MA Bannoud, TD Martins, JM Annichino-Bizzacchi, SAL Montalvão, RM Filho, MRW Maciel   +5 more
doaj   +1 more source

Unique circulating miRNAome signatures captured with distinct molecular states in Lynch syndrome and sporadic colorectal cancer

Molecular Oncology, EarlyView.
Circulating microRNA profiles distinguish nonmalignant Lynch syndrome from cancer‐associated Lynch syndrome, sporadic colorectal cancer, and healthy controls. Age‐stratified analysis reveals disease‐specific regulatory states, and a six‐miRNA panel shows concordant separation in an independent colorectal tissue cohort.
Ramadhani Salum Chambuso, Md Shohel Ul Islam, Rosa M Xicola, Raj Ramesar, Xavier Llor, Sinclair Steele   +5 more
wiley   +1 more source

Information cascade prediction of complex networks based on physics-informed graph convolutional network

New Journal of Physics
Cascade prediction aims to estimate the popularity of information diffusion in complex networks, which is beneficial to many applications from identifying viral marketing to fake news propagation in social media, estimating the scientific impact ...
Dingguo Yu, Yijie Zhou, Suiyu Zhang, Wenbing Li, Michael Small, Ke-ke Shang   +5 more
doaj   +1 more source

Profile Loss Prediction for Organic Rankine Cycle Turbines: An Experimental Case Study

International Journal of Turbomachinery, Propulsion and Power, 2023
The results of profile loss measurements, including trailing edge flow details, are presented for the flow of an organic vapor through a linear turbine cascade.
Leander Hake, Stephan Sundermeier, Stefan aus der Wiesche   +2 more
doaj   +1 more source

Cascaded multiple classifiers for secondary structure prediction [PDF]

Protein Science, 2000
AbstractWe describe a new classifier for protein secondary structure prediction that is formed by cascading together different types of classifiers using neural networks and linear discrimination. The new classifier achieves an accuracy of 76.7% (assessed by a rigorous full Jack‐knife procedure) on a new nonredundant dataset of 496 nonhomologous ...
Ouali, Mohammed, King, Ross D.
openaire   +3 more sources

Targeting the EpCAM‐AXL axis to overcome drug resistance in lung cancer

Molecular Oncology, EarlyView.
Lung cancer cells often evade therapy by hijacking signaling pathways. We reveal that cleaved EpCAM (sEpCAM) stabilizes the oncogenic protein AXL, driving NF‐κB and STAT3‐mediated chemoresistance. This EpCAM‐AXL axis identifies a high‐risk patient subset with poor prognosis.
Alexa Guerrero‐Alba, Mark Shacker, Timothy P. Fleming, Michael A. Smith, Ross M. Bremner, Narendra V. Sankpal   +5 more
wiley   +1 more source

DCCAFN: deep convolution cascade attention fusion network based on imaging genomics for prediction survival analysis of lung cancer

Complex & Intelligent Systems, 2023
Recently, lung cancer prediction based on imaging genomics has attracted great attention. However, such studies often have many challenges, such as small sample size, high-dimensional information redundancy, and the inefficiency of multimodal fusion ...
Liye Jia, Xueting Ren, Wei Wu, Juanjuan Zhao, Yan Qiang, Qianqian Yang   +5 more
doaj   +1 more source