Results 131 to 140 of about 7,001 (296)

Reliability Analysis Based on Markov Model, Economic Feasibility, and Efficiency Comparison for a Cascaded H-Bridge Multilevel Inverter Capable of Generating 27 Levels

IEEE Access
A cascaded H-bridge multilevel inverter (CHBMI) can increase the number of output voltage levels by increasing the number of H-bridge modules, thereby achieving low dv/dt stress and good total harmonic distortion (THD).
Seong Jin Lim, Sun-Pil Kim, Feel-Soon Kang, Sung-Geun Song   +3 more
doaj   +1 more source

Enhanced Glycolysis‐Driven Histone H3K18 Lactylation Regulates Epileptogenesis by Modulating the E3 Ubiquitin Ligase COP1

Advanced Science, EarlyView.
Neuronal PKM2‐driven glycolysis generates excess lactate that triggers histone H3K18 lactylation (H3K18la), establishing a pathogenic metabolic‐epigenetic axis in epilepsy. Elevated H3K18la enriches the Cop1 promoter, transcriptionally upregulating the E3 ubiquitin ligase COP1, which subsequently drives proteasomal degradation of GABAARβ2 and impairs ...
Yuan Meng, Yanlin Guo, Liumi Jiang, Jing Luo, Yan Liu, Ziwei Yuan, Pingyang Ke, Ran Duan, Fei Xiao   +8 more
wiley   +1 more source

Cross Kingdom Metabolic Engineering Paradigm Elevating Sustainable Protein Production

Advanced Science, EarlyView.
ABSTRACT Confronting the dual crisis of escalating global protein demand and unsustainable agriculture necessitates transformative solutions. Here, we pioneer evolutionary insights from maize nitrogen optimization via asparagine synthetase (ASNS) to rewire metabolism in Pichia pastoris.
Yuanyuan Du, Changyu Pi, Kai Hong, Le Gao, Xin Wu   +4 more
wiley   +1 more source

TSPYL5 Promotes Triple‐Negative Breast Cancer Metastasis by Antagonizing USP10‐Mediated PTEN Stabilization to Unleash a ZEB1‐Dependent EMT Program

Advanced Science, EarlyView.
The hyperactivation of PI3K/AKT signaling in PTEN wild‐type triple‐negative breast cancer represents a clinical paradox. We delineate a novel post‐translational regulatory axis wherein the oncogene TSPYL5 competitively antagonizes the deubiquitinase USP10.
Jiaying Shi, Ming Yi, Shengyu Xie, Zhaokun Wang, Xinyue Zhang, Yangwei Zhang, Rui Tang, Yuan Yang, Yunqiang Liu   +8 more
wiley   +1 more source

A Keratinocyte‐Mast Cell NF‐κB2/CXCL2/IL‐6 Amplification Loop Enhances Cutaneous Antifungal Defense Against C. albicans

Advanced Science, EarlyView.
ABSTRACT Mast cells (MCs), key innate immune sentinels at the host–environment interface, serve as primary responders to invading pathogens. However, their specific contribution to host defense against cutaneous Candida albicans (C. albicans) infection and their synergy with other immune and non‐immune cells remain poorly understood. Here, we show that
Yan Yuan, Manyun Mao, Jiaan Zhang, Zhimin Duan, JiaNing Wang, Yujie Chen, Sihan Chen, Chuting Liang, Xvyue Zhou, Songmei Geng, Min Li, Xu Chen, Ni Lian   +12 more
wiley   +1 more source

Single IGBT Open‐Circuit Fault Mitigation in Cascaded Converters Using Zero‐Mode Control and Half‐Wave Reconfiguration Composite Control

Energy Science & Engineering
This article proposes a composite fault‐tolerant control strategy combining zero‐mode control and half‐wave reconfiguration to address single IGBT open‐circuit faults in cascaded H‐bridge converters.
Lei Dong, Hanqiang Wang, Hao Jin, Rende Zhao, Member, IEEE, Huihui Hu   +5 more
doaj   +1 more source

A Fault-Tolerant Control Method Based on Reconfiguration SPWM Signal for Cascaded Multilevel IGBT-Based Propulsion in Electric Ships

Journal of Marine Science and Engineering
Electric ships have been developed in recent years to reduce greenhouse gas emissions. In this system, inverters are the key equipment for the permanent-magnet synchronous motor (PMSM) drive system.
Fan Zhang, Zhiwei Zhang, Zhonglin Zhang, Tianzhen Wang, Jingang Han, Yassine Amirat   +5 more
doaj   +1 more source

Modified Cascaded H-Bridge Multilevel Inverter using Trinary DC source

, 2018
In this paper, single phase nine level cascaded multilevel inverter using trinary voltage source is described. Normally for getting nine level MLI output, four H-Bridges are required.
T Murugan, N Booma Nagarajan, Anuja Prashant Diwan, S Ashrafudeen, G J. Jenito Paul   +4 more
core   +1 more source

Full‐Body AI Agent: A Perspective on Multi‐Scale Collaborative AI for Systemic Biology and Precision Medicine

Advanced Science, EarlyView.
We propose the Full‐Body AI Agent, a multi‐scale collaborative framework with 7 biological‐layer agents. It unifies multi‐omics/clinical data via standardized protocols, enabling phenotype‐guided closed‐loop reasoning, quantitative evaluation, and LLM safeguards, with promising applications in tumor metastasis modeling and precision drug development ...
Aoqi Wang, Jiajia Liu, Jianguo Wen, Yangyang Luo, Zhiwei Fan, Liren Yang, Xi Hu, Ruihan Luo, Yankai Yu, Sophia Li, Weiling Zhao, Xiaobo Zhou   +11 more
wiley   +1 more source

Frustrated Lewis Pairs and Metallic Ni Synergistically Enabled Low‐Temperature Hydrogenolysis of Lignin Models

Advanced Science, EarlyView.
Nickel–aluminum composite oxide (NiAlOx‐300) derived from NiAl layered double hydroxide showed high activity for hydrogenolysis of various lignin models. Especially, hydrogenolysis of benzyl phenyl ether could be efficiently proceeded at 20°C and 1 MPa H2.
Jinpeng Liang, Ziyi Ma, Zhaoxi Cai, Kongqian Liang, Chenglei Xiao, Sitong Chen, Na Wang, Zhimin Xue, Chao Xie, Jinliang Song   +9 more
wiley   +1 more source