Results 121 to 130 of about 11,187 (302)

Infusible Extracellular Matrix Biomaterial Enhances Cell‐Specific Pro‐Repair Responses Following Acute Myocardial Infarction

Advanced Healthcare Materials, EarlyView.
We measure the cell‐specific responses of administering infusible ECM (iECM) in acute myocardial infarction (MI) across multiple timepoints. Using single‐nucleus RNA sequencing and spatial transcriptomics, we measure macrophage activation, fibroblast remodeling, increased vascular development, lymphangiogenesis, cardioprotection, and neurogenesis ...
Joshua M. Mesfin, Alexander Chen, Quincy P. Lyons, Michael B. Nguyen, Maria L. Karkanitsa, Justin Yu, Van K. Ninh, Emily Gardner, Elyse G. Wong, Sriya N. Paleti, Julian Cheng, Benjamin D. Bridgelal, Kate E. Reimold, Selena Cao, Connor Uhre, Colin G. Luo, Zhenxing Fu, Kevin R. King, Karen L. Christman   +18 more
wiley   +1 more source

Chance constraint based risk-aware optimal power flow for cascading failure prevention

, 2016
Once part or whole of the power system is exposed to some dangerous situations, e.g., malicious terrorist attacks or extreme weather conditions, the potential cascading failure is a severe threat to the power system.
Chao Luo, Liu, Mingsong, Haibo He, Yang, Jun, Yufei Tang, Luo, Chao, He, Haibo, Jun Yang, Mingsong Liu, Tang, Yufei   +9 more
core   +1 more source

Flash Assembloids: A Rapid Biofabrication of a Platform for Modeling Early Glioblastoma Invasion at the Glioblastoma–Brain Organoid Interfaces

Advanced Healthcare Materials, EarlyView.
This study presents a bioengineered assembloid (ASM) system combining glioblastoma (GBM) cells in oxidized alginate (OA) microgels with dorsal organoids (DOs). This model simulates brain tumor‐host interactions, revealing enhanced GBM invasion, altered gene expression, and aggressive infiltration patterns, demonstrating ASM as a valuable platform for ...
Chao Liang, Henry Robert Howard, Shihui Chen, Won‐Young Choi, Summer Cao, Arthur Chien, Kevin Zou, Michael Kassiou, Fabien Delerue, Ho Sang Jung, Yeonju Park, Young Mee Jung, Yong‐Dae Kwon, Karrie M. Kiang, Gilberto Ka‐Kit Leung, Ryohichi Sugimura, Ann‐Na Cho, Sang Jin Lee   +17 more
wiley   +1 more source

A Branching Process Approximation to Cascading Load-Dependent System Failure

, 2004
Networked infrastructures operated under highly loaded conditions are vulnerable to catastrophic cascading failures. For example, electric power transmission systems must be designed and operated to reduce the risk of widespread blackouts caused by ...
Ian Dobson
core  

A Long‐Lived Human Neurovascular PENTA Culture Model Captures Incomplete Vascular Repair and Glia‐Associated Signaling After Traumatic Brain Injury

Advanced Healthcare Materials, EarlyView.
A long‐lived, five‐cell‐type human neurovascular (PENTA) model recreates vascular disorganization and incomplete repair after traumatic brain injury (TBI). By integrating endothelial, glial, neuronal, and immune components within a 3D scaffold, the platform enables time‐resolved analysis of neurovascular remodeling and provides a human‐relevant system ...
Daniel S. Hinrichsen, Sunghyun Jun, Colleen M. Arrasmith, Charitha C. Anamala, Mitchell D. Thielen, Anapaula Garcia, Volha Liaudanskaya   +6 more
wiley   +1 more source

Estimating failure propagation in models of cascading blackouts

, 2005
— We compare and test statistical estimates of failure propagation in data from versions of a probabilistic model of loading-dependent cascading failure and a power systems blackout model of cascading transmission line overloads.
David E. Newman, Bertrand Nkei, Vickie E. Lynch, Ian Dobson, Benjamin A. Carreras   +4 more
core  

Criticality in a cascading failure blackout model

, 2006
We verify and examine criticality in a 1000 bus network with an AC blackout model that represents many of the interactions that occur in cascading failure.
Nedic, Dusko P., Dobson, Ian, Kirschen, Daniel S., Dusko P. Nedic, Vickie E. Lynch, Lynch, Vickie E., Ian Dobson, Daniel S. Kirschen, Benjamin A. Carreras, Carreras, Benjamin A.   +9 more
core   +1 more source

Packed for Ossification: High‐Density Bioprinting of hPDC Spheroids in HAMA Toward Endochondral Ossification

Advanced Healthcare Materials, EarlyView.
Human periosteum‐derived cell spheroids bioprinted at high density within a hyaluronic acid matrix promote fusion and hypertrophic cartilage formation in vitro. Early encapsulation enhances spheroid interaction and matrix maturation, generating scalable cartilage templates intended for endochondral bone regeneration.
Ane Albillos Sanchez, Maria Paula Marks, Paula Casademunt, Adrián Seijas‐Gamardo, Ioannis Papantoniou, Lorenzo Moroni, Carlos Mota   +6 more
wiley   +1 more source

Identification of Cascading Failure Propagation Under Extreme Weather Conditions [PDF]

, 2018
As a fundamental infrastructure, power systems play a vital role in modern society, but it can be damaged by different adverse events e.g. natural, accidental, and malicious, of which the adverse natural events, especially extreme weathers, with huge ...
PI, RENJIAN
core  

Mitigating Multi-Stage Cascading Failure by Reinforcement Learning

, 2019
This paper proposes a cascading failure mitigation strategy based on Reinforcement Learning (RL) method. Firstly, the principles of RL are introduced. Then, the Multi-Stage Cascading Failure (MSCF) problem is presented and its challenges are investigated.
Chengxi Liu, Liu, Chengxi; id_orcid, Yongli Zhu, Zhu, Yongli   +3 more
core   +1 more source