Results 51 to 60 of about 11,187 (302)

The ubiquitin‐proteasome system and autophagy as guardians of the cellular proteome

FEBS Letters, EarlyView.
This Perspective covers the three principles governing the crosstalk between the ubiquitin‐proteasome system and autophagy in cellular proteostasis: (1) a shared ubiquitin code routing substrates via shuttle factors or autophagy receptors; (2) spatial compartmentalization into phase‐separated degradation hubs and organelle‐specific modules (exemplified
Ivan Dikic
wiley   +1 more source

Vulnerability Identification and Cascading Failure Spatiotemporal Patterns on Road Network under the Rainstorm Disaster

ISPRS International Journal of Geo-Information, 2022
Road vulnerability is crucial for enhancing the robustness of urban road networks and urban resilience. In medium or large cities, road failures in the face of unexpected events, such as heavy rainfall, can affect regional traffic efficiency and ...
Qirui Wu, Zhigang Han, Caihui Cui, Feng Liu, Yifan Zhao, Zhaoxin Xie   +5 more
doaj   +1 more source

Diversity of cascading failure processes in electrical grids

, 2015
Investigation of the cascading failure is of great importance to understanding wide-scale power outages in electrical grids. In the current literature, researchers mainly evaluate the severity of a cascading failure process based on assessing its final ...
Sun, Yan Lindsay, Haibo He, Zhu, Yihai, Yan Lindsay Sun, Jun Yan, Yufei Tang, He, Haibo, Yihai Zhu, Yan, Jun, Tang, Yufei   +9 more
core   +1 more source

Microbiome−host proteostasis crosstalk—An emerging perspective on mechanisms and interventions toward healthy longevity

FEBS Letters, EarlyView.
Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley   +1 more source

Fuzzy Partitioned Multi-objective Risk Framework Based Operational Risk Assessment of Cascading Failure for Power Grid

Zhongguo dianli
On the basis of analyzing the difference between the long-term evolution process and the short-term evolution process of the power grid, the concept of power grid cascading failure operation risk is proposed, the relationship between the long-term risk ...
Shi MO, Qiushi XU, Zijing LU, Zishou LI, Hongsheng ZHAO, Li QIAO, Chao LUO   +6 more
doaj   +1 more source

Quantify the Impact of Line Capacity Temporary Expansion on Blackout Risk by the State-Failure–Network Method

IEEE Access, 2019
The blackout risks of cascading failures in power systems are notably associated with the failures of transmission lines. Line capacity temporary expansion can reduce blackout risk by decreasing the line failures due to the overloads during the cascading
Linzhi Li, Hao Wu, Yonghua Song, Dunwen Song, Yi Liu   +4 more
doaj   +1 more source

Analysis of Vulnerability on Weighted Power Networks under Line Breakdowns

Entropy, 2022
Vulnerability is a major concern for power networks. Malicious attacks have the potential to trigger cascading failures and large blackouts. The robustness of power networks against line failure has been of interest in the past several years.
Lixin Yang, Ziyu Gu, Yuanchen Dang, Peiyan He   +3 more
doaj   +1 more source

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

Molecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano, Giuseppina Minopoli, Simona Romano, Laura Marrone, Katia Aquilano, Maria Lina Tornesello, Raffaella Faraonio   +6 more
wiley   +1 more source

Cascading Failure Analysis of Cyber Physical Power System With Multiple Interdependency and Control Threshold

IEEE Access, 2018
The traditional infrastructure in power system is undergoing a transition to the Smart Grid, in which the communication network and power grid will be integrated into a cyber-physical power system (CPPS).
Yu Chen, Yong Li, Wenguo Li, Xiaorui Wu, Ye Cai, Yijia Cao, Christian Rehtanz   +6 more
doaj   +1 more source

Abruptness of Cascade Failures in Power Grids [PDF]

Scientific Reports, 2014
Electric power-systems are one of the most important critical infrastructures. In recent years, they have been exposed to extreme stress due to the increasing demand, the introduction of distributed renewable energy sources, and the development of extensive interconnections.
Sakshi Pahwa, Caterina Scoglio, Antonio Scala   +2 more
openaire   +3 more sources