Results 171 to 180 of about 10,443,238 (288)

Residual tail twisting in ascidian larvae is stabilized by asymmetric myofibrils that resist bilateral symmetry restoration

FEBS Letters, EarlyView.
Ascidian Ciona larvae initially show strong clockwise tail twisting, which is largely corrected during development. However, a small residual twist remains. This study shows that organized helical myofibrils in tail muscles mechanically stabilize this residual asymmetry, preventing complete restoration of bilateral symmetry and revealing how embryos ...
Yuki S. Kogure, Misaki K. Nishio, Satoru Okuda, Kohji Hotta   +3 more
wiley   +1 more source

MOESM4 of Dysbiosis of the gut microbiome is associated with CKD5 and correlated with clinical indices of the disease: a caseâ controlled study

, 2019
Additional file 4: Fig. S1. IS chromatogram of the CKD5-HD group. Fig. S2. PCS chromatogram of the CKD5-HD group. Fig. S3. IS chromatogram of the CKD5-NHD group. Fig. S4. PCS chromatogram of the CKD5-NHD group.
Li, Yang, Su, Xinhuan, Zhang, Lei, Liu, Yanwei, Shi, Min, Lv, Chenxiao, Gao, Ying, Xu, Dongmei, Wang, Zunsong   +8 more
openaire   +1 more source

Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

Molecular Oncology, EarlyView.
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice, Jose I. Lopez, Aitziber Ugalde‐Olano, Maite Zufiaurre, Ianire Astobiza, Natalia Martin‐Martin, Laura Bozal‐Basterra, Saioa Garcia‐Longarte, Amaia Zabala‐Letona, Sofia Rey, Aida Santos‐Martin, Miguel Unda, Ana Loizaga‐Iriarte, Mariona Graupera, Paolo Nuciforo, Arkaitz Carracedo, Isabel Mendizabal   +16 more
wiley   +1 more source

Evaluation of Tuberculosis Recurrence and Its Determinants in the Southeast of Iran: A Nested Case-Control Study Based on Data From 2012 to 2018

مجله اپیدمیولوژی ایران, 2020
Background and Objectives: In addition to effective treatment, tuberculosis recurrence is a very important challenge regarding the treatment of this infection. This study was conducted to evaluate the risk factors associated with tuberculosis recurrence.
B Moatamedizadeh, H Ansari, A Payandeh, SM Tabatabae, A Ramazanpouramirdehi   +4 more
doaj  

MOESM1 of Evaluation of serum iron overload, AST:ALT ratio and log10ferritin:AST ratio among schizophrenia patients in the Kumasi Metropolis, Ghana: a case–control study

, 2019
Additional file 1: Table S1. Partial Pearson correlation between Iron markers and liver function markers among study participants.
W. Owiredu, Brenya, Peter, Yaw Osei, Laing, Edwin, Okrah, Clement, Obirikorang, Christian, Anto, Enoch, Acheampong, Emmanuel, Sampson Donkor   +8 more
openaire   +1 more source

Potential therapeutic targeting of BKCa channels in glioblastoma treatment

Molecular Oncology, EarlyView.
This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak, Karolina Pytlak, Sandra Jaworowska, Bogusz Kulawiak, Piotr Bednarczyk   +4 more
wiley   +1 more source

MOESM3 of The association between FABP7 serum levels with survival and neurological complications in acetaminophen-induced acute liver failure: a nested caseâ control study

, 2017
Additional file 3. Table S1. Demographic and clinical parameters in 150 APAP-ALF patients stratified by cerebral edema.
Karvellas, Constantine, Speiser, Jaime, MĂŠlanie Tremblay, Lee, William, Rose, Christopher   +4 more
openaire   +1 more source

PARP inhibition and pharmacological ascorbate demonstrate synergy in castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon, Peter T. Gallagher, Orly I. Richter, Neermala Poudel Neupane, Amy C. Mandigo, Jennifer J. McCann, Emanuela Dylgjeri, Irina Vasilevskaya, Christopher McNair, Channing J. Paller, Wm. Kevin Kelly, Karen E. Knudsen, Matthew J. Schiewer, Ayesha A. Shafi   +13 more
wiley   +1 more source

Additional file 4: of Absence of an association of human polyomavirus and papillomavirus infection with lung cancer in China: a nested caseâ control study

, 2016
Table S4. Association between human papillomavirus (HPV) seropositivitya (alternate threshold) and incident lung cancer, adjusted for matching variables, ever smoking, and years of education. (DOCX 26 kb)
Colombara, Danny, Manhart, Lisa, Carter, Joseph, Hawes, Stephen, Weiss, Noel, Hughes, James, Qiao, You-Lin, Taylor, Philip, Smith, Jennifer, Galloway, Denise   +9 more
openaire   +1 more source

Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin

Molecular Oncology, EarlyView.
The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla, Jan Kosla, Magdalena Prechova, Lukas Frick, Patricia Bortel, Yasmin Borutzki, Andrea Bileck, Christopher Gerner, Samuel M. Meier‐Menches, Selma Osmanagic‐Myers, Martin Gregor   +10 more
wiley   +1 more source