Results 81 to 90 of about 16,166,284 (299)

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

FEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li, Pedro A. Sánchez‐Murcia, Bernd Nidetzky   +2 more
wiley   +1 more source

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

FEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai, Mizuki Seo, Gyath Karadsheh, Fachrur Rizal Mahendra, Máté Á Demény, Ferenc Győry, János András Mótyán, László Fésüs, Endre Kristóf, Rini Arianti   +9 more
wiley   +1 more source

The planar cell polarity protein Vangl2 interacts with the PDZ‐domains of Scribble but not with a unique PDZ‐like domain in Inturned

FEBS Letters, EarlyView.
Structural and biochemical characterisations show that the planar cell polarity (PCP) protein Inturned harbours a unique PDZ‐like domain that does not bind canonical PDZ‐binding motifs (PBMs) like that of another PCP protein Vangl2. In contrast, the apical‐basal polarity protein Scribble contains four PDZ domains that bind Vangl2, but one PDZ domain ...
Stephan Wilmes, Jan Brysch, Carmen Gelze, Lilli Meier, Daniel Kümmel   +4 more
wiley   +1 more source

Exposure to autoimmune disorders is associated with increased Alzheimer’s disease risk in a multi-site electronic health record analysis

Cell Reports Medicine
Summary: Autoimmunity has been proposed to increase Alzheimer’s disease (AD) risk, but evaluating the clinical connection between autoimmune disorders and AD has been difficult in diverse populations.
Grace D. Ramey, Alice Tang, Thanaphong Phongpreecha, Monica M. Yang, Sarah R. Woldemariam, Tomiko T. Oskotsky, Thomas J. Montine, Isabel Allen, Zachary A. Miller, Nima Aghaeepour, John A. Capra, Marina Sirota   +11 more
doaj   +1 more source

Tau acetylation at K331 has limited impact on tau pathology in vivo

FEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto, Yukio Matsuba, Mika Takahashi, Takaomi C. Saido   +3 more
wiley   +1 more source

Determinants of Delayed Treatment-Seeking for Childhood Diarrheal Diseases in Southwest Ethiopia: A Case–Control Study

Pediatric Health, Medicine and Therapeutics, 2020
Adane Asefa,1 Qaro Qanche,1 Zufan Asaye,2 Lemi Abebe1 1Department of Public Health, College of Health Science, Mizan-Tepi University, Mizan Aman, Ethiopia; 2Department of Statistics, College of Natural Science, Mizan-Tepi University, Tepi ...
Asefa A, Qanche Q, Asaye Z, Abebe L
doaj  

Calpain small subunit homodimerization is robust and calcium‐independent

FEBS Letters, EarlyView.
Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy, Trina Dykstra‐MacPherson, Mathias A. Bell, Peter L. Davies, Ruby May A. Sullan   +4 more
wiley   +1 more source

Association Between HTRA1, GAS6 and IFNGR2 Gene Polymorphisms and Stroke Susceptibility in the Chinese Han Population

Pharmacogenomics and Personalized Medicine, 2023
Fan Zhang,1,* Hao Peng,1,* Chuanyi Fu,1 Yidong Deng,1 Mao Zhang,1 Wenan Li,1 Jian Zhong,1 Qing Zhou,1 Li Huang,1 Shuli Xiao,1 Jiannong Zhao2 1Department of Cerebrovascular Disease, Hainan Affiliated Hospital of Hainan Medical University, Hainan ...
Zhang F, Peng H, Fu C, Deng Y, Zhang M, Li W, Zhong J, Zhou Q, Huang L, Xiao S, Zhao J   +10 more
doaj  

African American Scholars at Case

African American Scholars at Case is a digital initiative that focuses on the presence of African Americans at Case Western Reserve University since its inception.
Johnson, Gwendolyn G. (Creatorcre), Adeyemon, Earnestine (Creatorcre)   +1 more
core  

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source