Results 131 to 140 of about 22,838,112 (390)

Real‐time assay of ribonucleotide reductase activity with a fluorescent RNA aptamer

FEBS Letters, EarlyView.
Ribonucleotide reductases (RNR) synthesize DNA building blocks de novo, making them crucial in DNA replication and drug targeting. FLARE introduces the first single‐tube real‐time coupled RNR assay, which enables isothermal tracking of RNR activity at nanomolar enzyme levels and allows the reconstruction of allosteric regulatory patterns and rapid ...
Jacopo De Capitani, Noemi E. Nwosu, Viktoria Gocke, Müge Kasanmascheff, Hannes Mutschler   +4 more
wiley   +1 more source

The association of food consumption and nutrient intake with endometriosis risk in Iranian women: A case-control study

International Journal of Reproductive BioMedicine, 2019
Background Endometriosis, defined as the attendance of endometrial-like lesions in extra uterine locations, causes pain, infertility, and reduced quality of life. Objective To evaluate the relationship between food consumption
Youseflu Samaneh, Sadatmahalleh ShahidehJahanian, Mottaghi Azadeh, Kazemnejad Anoshirvan   +3 more
doaj   +1 more source

Disordered but rhythmic—the role of intrinsic protein disorder in eukaryotic circadian timing

FEBS Letters, EarlyView.
Unstructured domains known as intrinsically disordered regions (IDRs) are present in nearly every part of the eukaryotic core circadian oscillator. IDRs enable many diverse inter‐ and intramolecular interactions that support clock function. IDR conformations are highly tunable by post‐translational modifications and environmental conditions, which ...
Emery T. Usher, Jacqueline F. Pelham
wiley   +1 more source

A Study of Gastroenteritis Outbreak in Hamadan District, Iran: A Case-Control Study

مجله اپیدمیولوژی ایران, 2020
Background and Objectives: Water and foodborne diseases are major causes of mortality worldwide. The aim of this study was to investigate the factors affecting an gastroenteritis outbreak in Hamadan county in summer of 2019.
M Karami, A Doosty Irani, SJ Battaei, L Rafati, M Javaheri, M Kheir Andish, M Farhadi, M Hashemi, K Mozafari, A Akhlagh, M Shojaeian, AR Maleki, R Rostam Abadi, SH Torkshavand, M Khodabakhshi   +14 more
doaj  

The Relationship between Shoe Fitting and Foot Health of Persons with Down Syndrome: A Case Control Study [PDF]

, 2018
César Calvo‐Lobo, Ana Ramos García, Marta Elena Losa‐Iglesias, Daniel López‐López, David Rodríguez‐Sanz, Carlos Romero‐Morales, Ricardo Vallejo   +6 more
openalex   +1 more source

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

FEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe, Tanmay Kumar Mohanty, Rashna Bhandari, Dorothea Fiedler   +3 more
wiley   +1 more source

Tuberculosis and gender: exploring the patterns in a case control study in Malawi. [PDF]

, 2004
BACKGROUND: In many populations there is an excess of tuberculosis in young women and older men. We explored possible explanations for these patterns, concentrating on human immunodeficiency virus (HIV) status, pregnancy, smoking, cooking smoke exposure,
Crampin, AC, Fine, PEM, Floyd, S, Glynn, JR, Malema, SS, Mwaungulu, FD, Mwinuka, VK, Ngwira, BMM, Warndorff, DK   +8 more
core  

The role of histone modifications in transcription regulation upon DNA damage

FEBS Letters, EarlyView.
This review discusses the critical role of histone modifications in regulating gene expression during the DNA damage response (DDR). By modulating chromatin structure and recruiting repair factors, these post‐translational modifications fine‐tune transcriptional programmes to maintain genomic stability.
Angelina Job Kolady, Siyao Wang
wiley   +1 more source

Substrate specificity of Burkholderia pseudomallei multidrug transporters is influenced by the hydrophilic patch in the substrate‐binding pocket

FEBS Letters, EarlyView.
Multidrug transporters BpeB and BpeF from the Gram‐negative pathogen Burkholderia pseudomallei have a hydrophilic patch in their substrate‐binding pocket. Drug susceptibility tests and growth curve analyses using an Escherichia coli recombinant expression system revealed that the hydrophilic patches of BpeB and BpeF are involved in the substrate ...
Ui Okada, Satoshi Murakami
wiley   +1 more source

Function‐driven design of a surrogate interleukin‐2 receptor ligand

FEBS Letters, EarlyView.
Interleukin (IL)‐2 signaling can be achieved and precisely fine‐tuned through the affinity, distance, and orientation of the heterodimeric receptors with their ligands. We designed a biased IL‐2 surrogate ligand that selectively promotes effector T and natural killer cell activation and differentiation. Interleukin (IL) receptors play a pivotal role in
Ziwei Tang, Zelin Cheng, Teng Li, Fulian Wang, Liangminghui Zhang, Xiuxiu He, Lili Liu, Wei Wang, Aibin Liang, Guang Yang   +9 more
wiley   +1 more source