Results 181 to 190 of about 39,437,158 (299)

WFS1 Deficiency Impairs PIAS4‐Associated SUMOylation and Increases Ubiquitin‐Mediated Spermatogenesis‐Related Protein Degradation Leading to Testicular Male Infertility

Advanced Science, EarlyView.
The findings establish a critical role for WFS1 in human male fertility. Mechanistically, WFS1 interacts with PIAS4 to promote the SUMOylation of key spermatogenesis‐associated proteins, which in turn competitively inhibits their K48‐linked ubiquitin‐mediated degradation during spermatogenesis.
Yunchuan Tian, Guicheng Zhao, Xiang Wang, Xinyao Tang, Gan Shen, Tiechao Ruan, Chuan Jiang, Shikun Zhao, Jincheng Zhang, Xinyue Cui, Liangchai Zhuo, Jun Ma, Yihong Yang, Tingting Lin, Ying Shen   +14 more
wiley   +1 more source

Emergency Department Presentations During Dry and Humid Heatwaves: A Case-Crossover Study in the Northern Territory, Australia. [PDF]

Geohealth
Boyd R, Wright A, Borchers-Arriagada N, Fox-Hughes P, Johnston FH, Burgess P, Ward T, Campbell SL.   +7 more
europepmc   +1 more source

Van der Waals Gap‐Confined Molecular Engineering of MoS2 for Selectivity‐Enhanced and Humidity‐Tolerant Gas Sensing

Advanced Science, EarlyView.
Molecular confinement within van der Waals gaps of MoS2 is established as a powerful design strategy for selective and stable chemical sensing. Ethanol‐confined films simultaneously tune electronic doping, surface wettability, and sulfur vacancy configurations, suppressing water interference while enhancing NO2 adsorption.
Jae Hyung Shim, Gwang Su Kim, Tae Hyung Lee, Jaeho Lee, Su‐Yeon Joung, Jung Hoon Kang, Jin Seok Kim, Jung‐Won An, Chong‐Yun Kang, Ho Won Jang, Jungwon Park, Ji‐Soo Jang, Chul‐Ho Lee   +12 more
wiley   +1 more source

Evaluating transient risk factors for avian influenza outbreaks in Canada using case-crossover study and machine learning. [PDF]

Poult Sci
Sekhavati I, Dara R, Sharif S, Aliabadi AA.   +3 more
europepmc   +1 more source

Self‐Adaptive Biomimetic Nanocomposite Hydrogel Orchestrates Dual‐Targeting and On‐Demand H2S Gasotransmission for Multifactorial Diabetic Wound Therapy

Advanced Science, EarlyView.
A self‐adaptive and biomimetic nanocomposite hydrogel is engineered to orchestrate dual‐targeting and on‐demand H2S gasotransmission for multifactorial diabetic wound therapy. By seamlessly integrating antibacterial, antioxidant, anti‐inflammatory, immunoregulatory, and pro‐angiogenic functions within a single platform, this hydrogel dynamically ...
Kefan Wu, Xiaoxue Yang, Yonghang Liu, Yi Xiao, Shiyu Meng, Ao Li, Yi Zhun Zhu, Hui Guo, Xiaolin Wang   +8 more
wiley   +1 more source

Association of erythropoiesis-stimulating agents and red blood cell transfusion with venous thrombosis in patients with cancer: a nationwide case-crossover study. [PDF]

Ann Med
Lee BH, Yu Y, Park J, Lee SR, Sung HJ, Lee J.   +5 more
europepmc   +1 more source

Enhancing Specific Stiffness of Nano‐Architected Materials Through Generative AI and Active Learning

Advanced Science, EarlyView.
A structure‐centric generative framework searches voxelated design space directly, coupling a variational autoencoder with multi‐objective optimization and active learning to progressively expand the validated design domain. The discovered nano‐architectures, realized as pyrolytic carbon by two‐photon lithography, deliver 18–23% higher stiffness and 26–
Jinwook Yeo, Peter Serles, Donggeun Park, Julia R. Greer, Seunghwa Ryu   +4 more
wiley   +1 more source

Association between ambient temperature and all-cause hospitalization by functional status in Japan: A time-stratified case-crossover study. [PDF]

Environ Epidemiol
Takeuchi H, Phung VLH, Miyamoto Y, Aso S, Ng CFS, Yuan L, Yasunaga H, Hashizume M.   +7 more
europepmc   +1 more source

Mechanism‐Informed Language Modeling and Oxygenated 3D Screening Identify Berberine–Enzalutamide Synergy in Prostate Cancer Models

Advanced Science, EarlyView.
By integrating knowledge‐augmented artificial intelligence with an oxygen‐supplemented 3D screening platform, a synergistic interaction between berberine and enzalutamide is identified. The framework integrates compound mechanisms of action with disease‐relevant signaling context to prioritize candidate combinations and generate testable pathway‐based ...
Chih‐Hui Lo, Katie Shi, Lina Kafadarian, Alexandra Bermudez, Johnny Diaz, Liam Edwards, Yunqi Hong, Ziyi Chen, Hyeonji Hwang, Weihong Yan, Alan Levinson, Robert Damoiseaux, Cho‐Jui Hsieh, Tanya Stoyanova, Andrew S. Goldstein, Neil Y.C. Lin   +15 more
wiley   +1 more source

Sliding Ferroelectric Metals: An Emerging Frontier

Advanced Science, EarlyView.
This Perspective highlights recent advances in sliding ferroelectric metals, focusing on the coexistence of switchable polarization and metallicity. Representative nonmagnetic and magnetic systems are discussed, together with Berry‐curvature memory, superconducting switching, triply‐coupled switching, magnetoelectric coupling, and electrically ...
Ying Yang, Zhenzhou Guo, Xia Cheng, Xiaotian Wang   +3 more
wiley   +1 more source