Results 111 to 120 of about 45,992,735 (391)

Organoids in pediatric cancer research

open access: yesFEBS Letters, EarlyView.
Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley   +1 more source

Argument Marking in Ditransitive Alignment Types

open access: yesLinguistic Discovery, 2005
This paper discusses the patterns of case-marking/adpositional marking and indexing of ditransitive clauses in the world's languages, i.e. clauses with an Agent, a Recipient and a Theme argument. It distinguishes three major alignment types, indirective,
Martin Haspelmath
doaj   +1 more source

Reciprocal control of viral infection and phosphoinositide dynamics

open access: yesFEBS Letters, EarlyView.
Phosphoinositides, although scarce, regulate key cellular processes, including membrane dynamics and signaling. Viruses exploit these lipids to support their entry, replication, assembly, and egress. The central role of phosphoinositides in infection highlights phosphoinositide metabolism as a promising antiviral target.
Marie Déborah Bancilhon, Bruno Mesmin
wiley   +1 more source

Competence and Praxis: Sequential Analysis in German Sociology

open access: yesForum: Qualitative Social Research, 2005
In German social research nowadays most qualitative methodologies employ sequential analysis. This article explores the similarities and differences in conceptualising and practising this method. First, the working consensus, conceived as a shared set of
Kai-Olaf Maiwald
doaj  

Case studies: understanding players and the contexts in which they play. Workshop on Crossing Domains: Diverse Perspectives on Players [PDF]

open access: yes, 2015
Over recent years, the study of games and players has become an established domain with HCI research. However, while a range of methods has been employed within this area, questions remain as to how to develop in-depth understandings of players and the ...
Cox, Anna, Iacovides, Ioanna
core  

The anti‐CRISPR protein AcrIE8.1 inhibits the type I‐E CRISPR‐Cas system by directly binding to the Cascade subunit Cas11

open access: yesFEBS Letters, EarlyView.
In this study, we present the structure of AcrIE8.1, a previously uncharacterized anti‐CRISPR protein that inhibits the type I‐E CRISPR‐Cas system. Through a combination of structural and biochemical analyses, we demonstrate that AcrIE8.1 directly binds to the Cas11 subunit of the Cascade complex to inhibit the CRISPR‐Cas system.
Young Woo Kang, Hyun Ho Park
wiley   +1 more source

Metagenomic next-generation sequencing identifies native valve Aspergillus fumigatus endocarditis with cerebral involvement: a case report

open access: yesFrontiers in Cardiovascular Medicine
Aspergillus endocarditis is a rare but highly fatal condition, particularly in immunocompromised patients. This case report describes a 74-year-old male with native valve Aspergillus fumigatus endocarditis and intracranial infection.
Weibing Wu   +4 more
doaj   +1 more source

An intracellular transporter mitigates the CO2‐induced decline in iron content in Arabidopsis shoots

open access: yesFEBS Letters, EarlyView.
This study identifies a gene encoding a transmembrane protein, MIC, which contributes to the reduction of shoot Fe content observed in plants under elevated CO2. MIC is a putative Fe transporter localized to the Golgi and endosomal compartments. Its post‐translational regulation in roots may represent a potential target for improving plant nutrition ...
Timothy Mozzanino   +7 more
wiley   +1 more source

Case Series: Unusual Presentation of Acanthamoeba Coinfection in the Cornea

open access: hybrid, 2022
Yu-Hsun Chuang   +4 more
openalex   +1 more source

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