Results 111 to 120 of about 10,420,359 (296)

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

open access: yesFEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe   +3 more
wiley   +1 more source

Hierarchical hybrid control: A case study [PDF]

open access: yes, 1994
A case study of the difficulties encountered in the design of hierarchical, hybrid control systems is presented. As our example we use the Intelligent Vehicle Highway System (IVHS) architecture proposed for vehicle platooning, a system that involves both
Datta N. Godbole   +2 more
core   +4 more sources

Infinite Horizon and Ergodic Optimal Quadratic Control for an Affine Equation with Stochastic Coefficients

open access: yes, 2008
We study quadratic optimal stochastic control problems with control dependent noise state equation perturbed by an affine term and with stochastic coefficients. Both infinite horizon case and ergodic case are treated.
Guatteri, Giuseppina, Masiero, Federica
core   +1 more source

The role of histone modifications in transcription regulation upon DNA damage

open access: yesFEBS Letters, EarlyView.
This review discusses the critical role of histone modifications in regulating gene expression during the DNA damage response (DDR). By modulating chromatin structure and recruiting repair factors, these post‐translational modifications fine‐tune transcriptional programmes to maintain genomic stability.
Angelina Job Kolady, Siyao Wang
wiley   +1 more source

Study of the Determinants of Foot-and-Mouth Disease in Iran: A Unit Level Case Control Study

open access: yesمجله اپیدمیولوژی ایران, 2016
Background and Objectives: Foot-and-mouth disease (FMD) is one of major contagious animal. The purpose of this study was to evaluate the determinants associated with FMD occurrence in farms. Methods: A case- control study was carried out in cattle farms.
F Bagheri Amiri   +7 more
doaj  

Substrate specificity of Burkholderia pseudomallei multidrug transporters is influenced by the hydrophilic patch in the substrate‐binding pocket

open access: yesFEBS Letters, EarlyView.
Multidrug transporters BpeB and BpeF from the Gram‐negative pathogen Burkholderia pseudomallei have a hydrophilic patch in their substrate‐binding pocket. Drug susceptibility tests and growth curve analyses using an Escherichia coli recombinant expression system revealed that the hydrophilic patches of BpeB and BpeF are involved in the substrate ...
Ui Okada, Satoshi Murakami
wiley   +1 more source

Organizational control & the Catholic Church: a case study [PDF]

open access: yes, 2007
This paper presents an analysis of the problem of child-abusing priests in the Catholic Church using data from the USA, UK and Ireland. The apparent scale of this issue raises crucial theoretical as well as policy issues.
Littler, Craig R., Randall, Julian
core  

Function‐driven design of a surrogate interleukin‐2 receptor ligand

open access: yesFEBS Letters, EarlyView.
Interleukin (IL)‐2 signaling can be achieved and precisely fine‐tuned through the affinity, distance, and orientation of the heterodimeric receptors with their ligands. We designed a biased IL‐2 surrogate ligand that selectively promotes effector T and natural killer cell activation and differentiation. Interleukin (IL) receptors play a pivotal role in
Ziwei Tang   +9 more
wiley   +1 more source

Mechanisms of parasite‐mediated disruption of brain vessels

open access: yesFEBS Letters, EarlyView.
Parasites can affect the blood vessels of the brain, often causing serious neurological problems. This review explains how different parasites interact with and disrupt these vessels, what this means for brain health, and why these processes matter. Understanding these mechanisms may help us develop better ways to prevent or treat brain infections in ...
Leonor Loira   +3 more
wiley   +1 more source

Risk Factors of Pre-Eclampsia: A Hospital Based Case Control Study

open access: yesNational Journal of Community Medicine, 2018
Introduction: Hypertension, complicating 5 to 7% of all pregnan- cies, is a leading cause of maternal and fetal morbidity, particu- larly due to pre-eclampsia, pre-eclampsia contributes about 8 to 10% of maternal deaths in India.
Shweta V Deshmukh   +3 more
doaj  

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