Results 91 to 100 of about 8,148,710 (302)
Frontiers in Psychiatry, 2017 This pilot study aimed to evaluate and examine an instrument that integrates relevant aspects of cross-sectoral (in- and outpatients) mental health care, is simply to use and shows satisfactory psychometric properties.
Yuriy Ignatyev +4 more
doaj +1 more source
The PI3Kδ inhibitor roginolisib (IOA‐244) preserves T‐cell function and activity
Molecular Oncology, EarlyView.Identification of novel PI3K inhibitors with limited immune‐related adverse effects is highly sought after. We found that roginolisib and idelalisib inhibit chronic lymphocytic leukemia (CLL) cells and Treg suppressive functions to similar extents, but roginolisib affects cytotoxic T‐cell function and promotion of pro‐inflammatory T helper subsets to a
Elise Solli +7 more
wiley +1 more source
The Case Study Method and The Methodology of Business History [PDF]
, 2016 In this brief paper I place the case study method within the methodology of business history and in a broader perspectiveof researching business and management.
Bátiz-Lazo, Bernardo
core +1 more source
BUDAMAF: Data Management in Cloud Federations
, 2018 Data management has always been a multi-domain problem even in the simplest cases. It involves, quality of service, security, resource management, cost management, incident identification, disaster avoidance and/or recovery, as well as many other ...
Anagnostopoulos, Dimosthenis +3 more
core +1 more source
Targeting p38α in cancer: challenges, opportunities, and emerging strategies
Molecular Oncology, EarlyView.p38α normally regulates cellular stress responses and homeostasis and suppresses malignant transformation. In cancer, however, p38α is co‐opted to drive context‐dependent proliferation and dissemination. p38α also supports key functions in cells of the tumor microenvironment, including fibroblasts, myeloid cells, and T lymphocytes.
Angel R. Nebreda
wiley +1 more source
Women-led Fisheries Management: A Case Study From Bangladesh [PDF]
, 2002 This is a case study of a women-led fishery in Bangladesh. Although women constitute 50% of the total population of Asia (Southern)-Bangladesh; only 18% are economically involved inthe total labor force. They are involved in diversified work within their
M. Ahmed, P. M. Thompson, P. Sultana
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Molecular Oncology, EarlyView.Meta‐transcriptome analysis identified FGF19 as a peptide enteroendocrine hormone associated with colorectal cancer prognosis. In vivo xenograft models showed release of FGF19 into the blood at levels that correlated with tumor volumes. Tumoral‐FGF19 altered murine liver metabolism through FGFR4, thereby reducing bile acid synthesis and increasing ...
Jordan M. Beardsley +5 more
wiley +1 more source
Molecular Oncology, EarlyView.Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova +25 more
wiley +1 more source
Evidence-Based Management in "Macro" Areas: The Case of Strategic Management [PDF]
Despite its intuitive appeal, evidence-based management (EBMgt) faces unique challenges in "macro" areas such as Organization Theory and Strategy Management, which emphasize actions by organizations, and business and corporate leaders. The inherent focus
Madhavan, Ravi, Mahoney, Joseph T.
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The propagation of technology management taxonomies for evaluating investments in information systems [PDF]
, 2001 To provide managers with a critical insight into the management of new technology, this paper uses a case study research strategy to examine the technology management experiences of a leading UK manufacturing organization during its adoption of a vendor ...
Irani, Z, Love, PE
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