Results 101 to 110 of about 8,148,710 (302)
RIPK4 function interferes with melanoma cell adhesion and metastasis
Molecular Oncology, EarlyView.RIPK4 promotes melanoma growth and spread. RIPK4 levels increase as skin lesions progress to melanoma. CRISPR/Cas9‐mediated deletion of RIPK4 causes melanoma cells to form less compact spheroids, reduces their migratory and invasive abilities and limits tumour growth and dissemination in mouse models.
Norbert Wronski +9 more
wiley +1 more source
Corrigendum to “Coronavirus Disease-19: The First 7,755 Cases in the Republic of Korea” [Osong Public Health Res Perspect 2020;11(2):85–90] [PDF]
Osong Public Health and Research Perspectives, 2020 COVID-19 National Emergency Response Center, Epidemiology and Case Management Team +1 more
doaj +1 more source
Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma
Molecular Oncology, EarlyView.The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic +5 more
wiley +1 more source
Health Technology Assessment, 2014 Background: People with dementia and their families need support in different forms, but currently services are often fragmented with variable quality of care.
Steve Iliffe +14 more
doaj +1 more source
Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer
Molecular Oncology, EarlyView.Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni +11 more
wiley +1 more source
Diversity management and the business case [PDF]
Managing for diversity is a management strategy that intends to make productive use of (ethnic and other) differences between individuals. It is based on the premise that - at least if they are well managed - diverse teams will produce better results and
Fischer, Michael
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Multi-channel customer management: A case study in Egypt [PDF]
, 2009 Channel management is one CRM systems component much influenced by the behaviour of customers in relation to the implementation and use of channel management CRM component.
Ali, M, Brooks, L
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Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer
Molecular Oncology, EarlyView.Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley +1 more source
A Case-study of the Murray-Darling Basin [PDF]
Consultancy report for the International Water Management Institute. This case study was commissioned by the International Water Management Institute as part of an Asian Development Bank supported regional study on water management institutions.
Darla Hatton MacDonald, Mike Young
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Case Study on Design Management: Inefficiencies and Possible Remedies [PDF]
, 2015 Delivering better products with a reduced lead time and less resources has become the primary focus of design management. The aim of this work is to revisit typical design management inefficiencies and discuss possible remedies for these problems.
Dave, Bhargav +3 more
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