Results 111 to 120 of about 8,125,667 (302)
Molecular Oncology, EarlyView.CDK11 inhibition stabilises the tumour suppressor p53 and triggers the production of an alternative p21WAF1 splice variant p21L, through the inactivation of the spliceosomal protein SF3B1. Unlike the canonical p21WAF1 protein, p21L is localised in the cytoplasm and has reduced cell cycle‐blocking activity.
Radovan Krejcir +12 more
wiley +1 more source
Diversity management and the business case [PDF]
Managing for diversity is a management strategy that intends to make productive use of (ethnic and other) differences between individuals. It is based on the premise that - at least if they are well managed - diverse teams will produce better results and
Fischer, Michael
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The propagation of technology management taxonomies for evaluating investments in information systems [PDF]
, 2001 To provide managers with a critical insight into the management of new technology, this paper uses a case study research strategy to examine the technology management experiences of a leading UK manufacturing organization during its adoption of a vendor ...
Irani, Z, Love, PE
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Molecular Oncology, EarlyView.HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto +13 more
wiley +1 more source
Teaching operations management using a 'pseudo'-scientific approach [PDF]
, 2015 The purpose of this paper is to explore a theory led approach to teaching operations and supply chain management that has emerged from the analysis of seminal operations management developments and case research.
Stratton, R
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Molecular Oncology, EarlyView.We developed and validated a DNA methylation–based biomarker panel to distinguish pleural mesothelioma from other pleural conditions. Using the IMPRESS technology, we translated this panel into a clinically applicable assay. The resulting two classifier models demonstrated excellent performance, achieving high AUC values and strong diagnostic accuracy.
Janah Vandenhoeck +12 more
wiley +1 more source
International Journal of Integrated Care, 2013 M.S.B. Ma'Arof, P.W. EU, M. Hendriks
doaj +3 more sources
Foreign Exchange Risk Management Case Study: RJR NABISCO [PDF]
, 1995 This article presents a case analysis of RJR Nabisco Holdings Corporation's foreign exchange management. The strategy pursued by RJR Nabisco, the two headed-hedging strategy succeded in lowering it's foreign exchange ...
Primanita, P. (Primanita)
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Molecular Oncology, EarlyView.Liquid biopsy enables minimally invasive, real‐time molecular profiling through analysis of circulating biomarkers in biological fluids. This Perspective highlights the importance of training pathologists through integrative educational programs, such as the European Masters in Molecular Pathology, to ensure effective and equitable implementation of ...
Marius Ilié +13 more
wiley +1 more source
Worksite-based cardiovascular risk screening and management: a feasibility study
Vascular Health and Risk Management, 2017 Raj Padwal,1 Mohammad Rashead,2 Jonathan Snider,2 Louise Morrin,2 Agnes Lehman,2 Norm RC Campbell3 1Department of Medicine, Alberta Diabetes Institute and Mazankowski Alberta Heart Institute, University of Alberta, Edmonton, 2Cardiovascular Health and ...
Padwal R +5 more
doaj