Modelling stem cell differentiation related processes—A practical overview for biologists
Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar +4 more
wiley +1 more source
Analysing case in spoken language: A corpus study on East Franconian dialects
Due to phonological and morphological processes, there has been an excessive reduction of case forms in the development of the German case system. Thus, syncretism is frequently found in Standard German and even more so in German dialects, where the ...
Sophie Ellsäßer
doaj +1 more source
Children learn ergative case marking in Hindi using statistical preemption and clause-level semantics (intentionality): evidence from acceptability judgment and elicited production studies with children and adults. [PDF]
Maitreyee R +7 more
europepmc +1 more source
Design and analysis strategies for robust microbiome ageing research
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik +5 more
wiley +1 more source
This paper examines the rise of pronominal copies in relative clauses in L.A. Spanish, a variety that has an advanced degree of Case Marking Loss (CML) in these constructions.
Alazne Landa
doaj +1 more source
Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta +3 more
wiley +1 more source
Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics
Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt +8 more
wiley +1 more source
Differential Object Marking, Case and Agreement
In this paper, we present empirical evidence showing that Differential Object Marking (DOM) in Spanish is determined by structural conditions related to Case and agreement. We also argue that semantic concepts such as specificity, definiteness, animacy,
Javier Ormazabal, Juan Romero
doaj +1 more source
Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang +2 more
wiley +1 more source
This study undertakes an analysis of how ergative/absolutive Case marking takes place in Basque, a structure which appears to be similar to that of an accusative language.
José Ignacio Hualde
doaj +1 more source

