Results 131 to 140 of about 10,835,507 (313)

The Anatomy of Discretion: An Analysis of Prosecutorial Decision Making [PDF]

open access: yes, 2012
Prosecuting attorneys enjoy exceptionally broad discretion in making decisions that influence criminal case outcomes. They make pivotal decisions throughout the life of a case with little public or judicial scrutiny.
Bruce Frederick, Don Stemen
core  

A methionine‐lined active site governs carbocation stabilization and product specificity in a bacterial terpene synthase

open access: yesFEBS Letters, EarlyView.
This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel   +13 more
wiley   +1 more source

Diversity and complexity in neural organoids

open access: yesFEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source

\ud Case Report: Unsuspected Uterine Choriocarcinoma with Lung Metastasis\ud [PDF]

open access: yes, 2010
Choriocarcinoma is a rare form of cancer which commonly occurs in women of reproductive age, rarely in post-menopausal women and in women under 20 years of age.
Faustine, Lucas   +8 more
core  

Linking neurogenesis, oligodendrogenesis, and myelination defects to neurodevelopmental disruption in primary mitochondrial disorders

open access: yesFEBS Letters, EarlyView.
Mitochondrial remodeling shapes neural and glial lineage progression by matching metabolic supply with demand. Elevated OXPHOS supports differentiation and myelin formation, while myelin compaction lowers mitochondrial dependence, revealing mitochondria as key drivers of developmental energy adaptation.
Sahitya Ranjan Biswas   +3 more
wiley   +1 more source

Polyneuropathy - Case report [PDF]

open access: yesDMW - Deutsche Medizinische Wochenschrift, 2002
B, Schlotter-Weigel, D E, Pongratz
openaire   +2 more sources

The ubiquitin ligase RNF115 is required for the clearance of damaged lysosomes

open access: yesFEBS Letters, EarlyView.
Upon lysosomal rupture, an E3 ubiquitin ligase RNF115 translocates from the cytosol to the damaged lysosomal membrane. Moreover, RNF115 depletion impairs the clearance of damaged lysosomes, identifying it as a key regulator of lysosomal quality control.
Sae Nakanaga   +3 more
wiley   +1 more source

Case Report: Acute Supraglottitis [PDF]

open access: yes, 2020
Chu, Jamie Robin, Rogg, Jonathan G
core  

ImpaCT2 academic report: part 4 - case study evaluations [PDF]

open access: yes, 2002
This report explored the ways in which the integration of ICT and networked technologies into the curriculum tends to produce changes in the patterns of teaching and learning.

core  

Organizing the interface—Plasma membrane architecture and receptor dynamics in virus‐cell interactions

open access: yesFEBS Letters, EarlyView.
Plasma membranes contain dynamic nanoscale domains that organize lipids and receptors. Because viruses operate at similar scales, this architecture shapes early infection steps, including attachment, receptor engagement, and entry. Using influenza A virus and HIV‐1 as examples, we highlight how receptor nanoclusters, multivalent glycan interactions ...
Jan Schlegel, Christian Sieben
wiley   +1 more source

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