Results 221 to 230 of about 18,200,838 (244)
Molecular Oncology, EarlyView.The kinase SRPK1 directly interacts with the protein TOPBP1 and regulates the pre‐mRNA splicing of WIZ thereby contributing to the activation of the ATR/CHK1 replicative checkpoint in response to replicative stress. This allows cancer cells' genomic stability and survival.
Amani Shreim +17 more
wiley +1 more source
Mutant p53R273H disrupts PDPK1 homodimerization and contributes to PDPK1 activation
Molecular Oncology, EarlyView.How mutant p53R273H drives AKT signaling is unclear. We show that p53R273H, but not wild‐type, directly binds PDPK1 via a mutation‐dependent conformational change. This interaction disrupts inhibitory PDPK1 homodimerization and enhances AKT phosphorylation.
Mei Chee Lim +11 more
wiley +1 more source
Targeting the EpCAM‐AXL axis to overcome drug resistance in lung cancer
Molecular Oncology, EarlyView.Lung cancer cells often evade therapy by hijacking signaling pathways. We reveal that cleaved EpCAM (sEpCAM) stabilizes the oncogenic protein AXL, driving NF‐κB and STAT3‐mediated chemoresistance. This EpCAM‐AXL axis identifies a high‐risk patient subset with poor prognosis.
Alexa Guerrero‐Alba +5 more
wiley +1 more source
Molecular Oncology, EarlyView.LVRF (lymphatic and vascular resistance factor) is a VEGFA splice variant upregulated in response to anti‐angiogenic therapy that fosters tumor adaptation through enhanced vascularization, lymphangiogenesis, and metastatic dissemination. Targeting LVRF with fully human neutralizing antibodies disrupts these processes and limits resistant tumor growth ...
Marion David +12 more
wiley +1 more source
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Pediatrics, 2018
Whether it's raising new hypotheses, finding individual case exceptions to current paradigms, providing alerts to untoward outcomes, or suggesting new therapies to be further tested, the case report remains a viable form of medical publication.
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Whether it's raising new hypotheses, finding individual case exceptions to current paradigms, providing alerts to untoward outcomes, or suggesting new therapies to be further tested, the case report remains a viable form of medical publication.
openaire +2 more sources
JAMA: The Journal of the American Medical Association, 1968
The case report is the archetypical medical article. Medical journalism began as the publication of scientists' letters. Only a moderate formalization was needed to convert a letter about an interesting patient into a communication having the usual pattern of introduction, report of case, and discussion. Most authors and editors today consider this the
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The case report is the archetypical medical article. Medical journalism began as the publication of scientists' letters. Only a moderate formalization was needed to convert a letter about an interesting patient into a communication having the usual pattern of introduction, report of case, and discussion. Most authors and editors today consider this the
openaire +2 more sources
Journal of Professional Nursing, 1990
The nursing care of a patient following subarachnoid hemorrhage (SAH) is challenging and multifaceted. Physical and emotional support through the acute period following the insult and preparation for the rehabilitative process are among the early goals of care. This case report provides a detailed interpretation of the physical and behavioral responses
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The nursing care of a patient following subarachnoid hemorrhage (SAH) is challenging and multifaceted. Physical and emotional support through the acute period following the insult and preparation for the rehabilitative process are among the early goals of care. This case report provides a detailed interpretation of the physical and behavioral responses
openaire +2 more sources
2022
Bahir Dar University Journal of Law, Vol 11 No 1 (2020): Bahir Dar University Journal of ...
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Bahir Dar University Journal of Law, Vol 11 No 1 (2020): Bahir Dar University Journal of ...
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The Journal of Dermatology, 2001
AbstractAlkaptonuria is a rare, autosomally recessive, metabolic disorder caused by a deficiency in homogentisic acid oxidase. It results in accumulation and deposition of homogentisic acid in cartilage, eyelids, forehead, cheeks, axillae, genital regions, nail beds, buccal mucosa, larynx, tympanic eardrum, and the tendons.
Erdem, T +4 more
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AbstractAlkaptonuria is a rare, autosomally recessive, metabolic disorder caused by a deficiency in homogentisic acid oxidase. It results in accumulation and deposition of homogentisic acid in cartilage, eyelids, forehead, cheeks, axillae, genital regions, nail beds, buccal mucosa, larynx, tympanic eardrum, and the tendons.
Erdem, T +4 more
openaire +3 more sources
Tumori Journal, 2001
Parachordoma is a very rare soft tissue tumor with histological features similar to chordoma and chondrosarcoma. It should be distinguished from metastatic chordoma and extraskeletal myxoid chondrosarcoma because of its different treatment and prognosis. In this paper we report one case of parachordoma in a 20-year-old female patient.
Šeparović, Robert +4 more
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Parachordoma is a very rare soft tissue tumor with histological features similar to chordoma and chondrosarcoma. It should be distinguished from metastatic chordoma and extraskeletal myxoid chondrosarcoma because of its different treatment and prognosis. In this paper we report one case of parachordoma in a 20-year-old female patient.
Šeparović, Robert +4 more
openaire +4 more sources