Results 221 to 230 of about 16,614,391 (244)
Molecular Oncology, EarlyView.This study identifies somatostatin receptor 4 (Sstr4) as a critical tumor suppressor against skin and head/neck cancers (HNSCC, cSCC, and BCC). The loss of Sstr4 removes a check on cell growth, causing hyperactivation of the MAPK‐ERK signaling pathway (↑).
Ali Taqvi +6 more
wiley +1 more source
ADP‐ribosylation: An emerging regulator of the epigenome
Molecular Oncology, EarlyView.ADP‐ribosylation has emerged as a dynamic epigenetic signaling mechanism that modifies histones and chromatin‐associated proteins. Through coordinated PARylation and MARylation, it integrates with other histone modifications to regulate chromatin structure, transcription factor activity, and gene expression, influencing genome function and disease ...
Cristel V. Camacho +2 more
wiley +1 more source
Molecular Oncology, EarlyView.We show that emergence of castration‐resistant prostate (CRPC) is associated with significant upregulation of cyclins that positively regulate cyclin‐dependent kinase 2 (CDK2) and concomitant downregulation of CDK4 cyclins. This renders CRPC cells dependent on the high activity of CDK2, and CDK2 inhibitors synergistically sensitize CRPC cells to both ...
Joyeeta Chatterjee +3 more
wiley +1 more source
Molecular Oncology, EarlyView.Partial inhibition of focal adhesion kinase (FAK) can paradoxically promote tumor growth, rather than simply producing a weaker antitumor effect than that observed with strong FAK suppression. In breast cancer and melanoma models, targeting p110δ PI3K, particularly in macrophages, counteracted these tumor‐promoting effects, highlighting the importance ...
Lydia Xenou +4 more
wiley +1 more source
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Pediatrics, 2018
Whether it's raising new hypotheses, finding individual case exceptions to current paradigms, providing alerts to untoward outcomes, or suggesting new therapies to be further tested, the case report remains a viable form of medical publication.
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Whether it's raising new hypotheses, finding individual case exceptions to current paradigms, providing alerts to untoward outcomes, or suggesting new therapies to be further tested, the case report remains a viable form of medical publication.
openaire +2 more sources
2022
Bahir Dar University Journal of Law, Vol 11 No 1 (2020): Bahir Dar University Journal of ...
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Bahir Dar University Journal of Law, Vol 11 No 1 (2020): Bahir Dar University Journal of ...
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JAMA: The Journal of the American Medical Association, 1968
The case report is the archetypical medical article. Medical journalism began as the publication of scientists' letters. Only a moderate formalization was needed to convert a letter about an interesting patient into a communication having the usual pattern of introduction, report of case, and discussion. Most authors and editors today consider this the
openaire +2 more sources
The case report is the archetypical medical article. Medical journalism began as the publication of scientists' letters. Only a moderate formalization was needed to convert a letter about an interesting patient into a communication having the usual pattern of introduction, report of case, and discussion. Most authors and editors today consider this the
openaire +2 more sources
Journal of Professional Nursing, 1990
The nursing care of a patient following subarachnoid hemorrhage (SAH) is challenging and multifaceted. Physical and emotional support through the acute period following the insult and preparation for the rehabilitative process are among the early goals of care. This case report provides a detailed interpretation of the physical and behavioral responses
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The nursing care of a patient following subarachnoid hemorrhage (SAH) is challenging and multifaceted. Physical and emotional support through the acute period following the insult and preparation for the rehabilitative process are among the early goals of care. This case report provides a detailed interpretation of the physical and behavioral responses
openaire +2 more sources
The Journal of Dermatology, 2001
AbstractAlkaptonuria is a rare, autosomally recessive, metabolic disorder caused by a deficiency in homogentisic acid oxidase. It results in accumulation and deposition of homogentisic acid in cartilage, eyelids, forehead, cheeks, axillae, genital regions, nail beds, buccal mucosa, larynx, tympanic eardrum, and the tendons.
Erdem, T +4 more
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AbstractAlkaptonuria is a rare, autosomally recessive, metabolic disorder caused by a deficiency in homogentisic acid oxidase. It results in accumulation and deposition of homogentisic acid in cartilage, eyelids, forehead, cheeks, axillae, genital regions, nail beds, buccal mucosa, larynx, tympanic eardrum, and the tendons.
Erdem, T +4 more
openaire +3 more sources
Tumori Journal, 2001
Parachordoma is a very rare soft tissue tumor with histological features similar to chordoma and chondrosarcoma. It should be distinguished from metastatic chordoma and extraskeletal myxoid chondrosarcoma because of its different treatment and prognosis. In this paper we report one case of parachordoma in a 20-year-old female patient.
Šeparović, Robert +4 more
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Parachordoma is a very rare soft tissue tumor with histological features similar to chordoma and chondrosarcoma. It should be distinguished from metastatic chordoma and extraskeletal myxoid chondrosarcoma because of its different treatment and prognosis. In this paper we report one case of parachordoma in a 20-year-old female patient.
Šeparović, Robert +4 more
openaire +4 more sources