Results 201 to 210 of about 5,197,384 (308)

From bright ideas to tools: the case of malaria.

PLoS Neglected Tropical Diseases, 2015
Melba F Gomes, Annette C Kuesel
doaj   +1 more source

ClarID: a human-readable and compact identifier specification for biomedical metadata integration. [PDF]

J Biomed Semantics
Rueda M, Gut IG.
europepmc   +1 more source

Proteasomal degradation of intracellularly expressed Amblyomin‐X limits suicide gene therapy potential in melanoma cells

FEBS Open Bio, EarlyView.
This study explores the feasibility of expressing the antitumoral protein Amblyomin‐X through a suicide gene therapy approach and investigates its intracellular fate after gene delivery. Although the gene is efficiently expressed, melanoma cells rapidly degrade the Amblyomin‐X protein via proteasome activity.
Victor Dal Posolo Cinel, Carlos DeOcesano Pereira, Aline Ramos Maia Lobba, Melissa Regina Fessel, Ana Marisa Chudzinski‐Tavassi   +4 more
wiley   +1 more source

Improving knowledge of metagenome-assembled genomes (MAGs) through bioinformatics and article annotation. [PDF]

J Microbiol Biol Educ
Whitham JM, Goller CC.
europepmc   +1 more source

MiR‐513a promotes human erythroid differentiation by modulating c‐Jun

FEBS Open Bio, EarlyView.
During early human erythropoiesis, miR‐513a promoted erythroid differentiation in primary human CD34+ hematopoietic stem‐progenitor cells and human TF‐1 erythroleukemic cells by indirectly decreasing c‐Jun and phospho‐c‐Jun expression, which are associated with increased GATA1 expression.
MinJung Kim, Brittany Taylor, Shannon Bolten, Christian L. Eberly, Mahliya Abdurahman, T. Michael Creed, Acong Yang, Taylor L. Hatchet, Tristan Dyson, Shuo Gu, Curt I. Civin, Tami J. Kingsbury   +11 more
wiley   +1 more source

ClinGen Bayesian-Framework-Guided Interpretation of Compound Heterozygous <i>F12</i> Variants in a Pregnant Woman with Factor XII Deficiency: A Case Report. [PDF]

Diagnostics (Basel)
Park KS, Cho HE.
europepmc   +1 more source

Decreased cold‐sensing function of the transient receptor potential channel TRPM8 from tailed amphibians

FEBS Open Bio, EarlyView.
Despite frogs avoiding low temperatures, examination of four salamander species revealed that none avoided cold and all possessed cold tolerance. Functional analysis of TRPM8, a cold sensor, showed that all salamander TRPM8s had lost their cold sensitivity.
Tadahiro Sawao, Daiki Kobayashi, Shogo Hori, Osamu Saitoh   +3 more
wiley   +1 more source

Can we optimise the TB response amid funding constraints using evidence-based, cost-effective strategies. [PDF]

IJTLD Open
Yassin MA, Rashid A, Wandwalo E.
europepmc   +1 more source

Digital twins to accelerate target identification and drug development for immune‐mediated disorders

FEBS Open Bio, EarlyView.
Digital twins integrate patient‐derived molecular and clinical data into personalised computational models that simulate disease mechanisms. They enable rapid identification and validation of therapeutic targets, prediction of drug responses, and prioritisation of candidate interventions.
Anna Niarakis, Philippe Moingeon
wiley   +1 more source

Emerging Integrating Approach to Sensors, Digital Signal Processing, Communication Systems, and Artificial Intelligence. [PDF]

Sensors (Basel)
Procházka A, Vyšata O, Charvátová H, Dytrych P, Janáková D, Mařík V.   +5 more
europepmc   +1 more source