Results 151 to 160 of about 55,584 (294)

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

Molecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker, Keren Zohar, Martin Böttcher, Thomas Wartmann, Henry Freudenstein, Maximilian Doelling, Mihailo Andric, Wenjie Shi, Or Kakhlon, Katrin Hippe, Beatrix Jahnke, Dimitrios Mougiakakos, Franziska Baenke, Daniel Stange, Roland S. Croner, Michal Linial, Ulf D. Kahlert   +16 more
wiley   +1 more source

Research on casing damage risk early warning technology based on MIT-MTT logging and 16S rRNA gene analysis. [PDF]

Front Microbiol
Wang S, Wang S, Li C, Zhou C, Jiang L.
europepmc   +1 more source

Energy efficient engine: Preliminary design and integration studies [PDF]

Parametric design and mission evaluations of advanced turbofan configurations were conducted for future transport aircraft application. Economics, environmental suitability and fuel efficiency were investigated and compared with goals set by NASA. Of the
Hirschkron, R., Johnston, R. P., Koch, C. C., Neitzel, R. E., Vinson, P. W.   +4 more
core   +1 more source

Predictors of response and rational combinations for the novel MCL‐1 inhibitor MIK665 in acute myeloid leukemia

Molecular Oncology, EarlyView.
This study characterizes the responses of primary acute myeloid leukemia (AML) patient samples to the MCL‐1 inhibitor MIK665. The results revealed that monocytic differentiation is associated with MIK665 sensitivity. Conversely, elevated ABCB1 expression is a potential biomarker of resistance to the treatment, which can be overcome by the combination ...
Joseph Saad, Rhiannon Newman, Elmira Khabusheva, Sofia Aakko, Eric Durand, Mahesh Tambe, Heikki Kuusanmäki, Alun Parsons, Juho J. Miettinen, Komal Kumar Javarappa, Ezgi June Olgac, Nemo Ikonen, Mika Kontro, Kimmo Porkka, Heiko Maacke, Janghee Woo, Ensar Halilovic, Caroline A. Heckman   +17 more
wiley   +1 more source

Spent casing, Sphagnum moss, grass fibers, and green compost as peat alternatives in casing soils for Agaricus bisporus cultivation. [PDF]

Sci Rep
Gorter FA, van Rooijen R, Hendrix E, Hendriks M, Mendes O, Lombaers C, Krijger M, Taparia T, van der Wolf JM.   +8 more
europepmc   +1 more source

Feasibility of a ctDNA multigenic panel for non‐small‐cell lung cancer early detection and disease surveillance

Molecular Oncology, EarlyView.
Plasma‐based detection of actionable mutations is a promising approach in lung cancer management. Analysis of ctDNA with a multigene NGS panel identified TP53, KRAS, and EGFR as the most frequently altered, with TP53 and KRAS in treatment‐naïve patients and TP53 and EGFR in previously treated patients.
Giovanna Maria Stanfoca Casagrande, Marcela de Oliveira Silva, Mariana Bisarro dos Reis, Rodrigo de Oliveira Cavagna, Luciane Sussuchi, Icaro Alves Pinto, Natalia Zampieri Pontes, Rodrigo Sampaio Chiarantano, Flavio Augusto Ferreira da Silva, Pedro de Marchi, Letícia Ferro Leal, Rui M. Reis   +11 more
wiley   +1 more source

Mechanisms of Differential Resource Uptake and Translocation in Agaricus bisporus. [PDF]

Environ Microbiol
Vîta MM, van Veghel TLG, Polerecky L, van der Wel NN, Eefting DD, Middelburg JBM, Bleichrodt RJ.   +6 more
europepmc   +1 more source

Effect of slotted casing treatment on performance of a multistage compressor [PDF]

A J85-13 engine was equipped with a compressor case that allowed changes to the case wall over the rotor tips of six of its eight stages. The engine was tested with four inlet configurations: uniform inlet flow, 180 degree circumferential distortion, hub
Moss, J. E., Jr.
core   +1 more source

Tumor and germline testing with next generation sequencing in epithelial ovarian cancer: a prospective paired comparison using an 18‐gene panel

Molecular Oncology, EarlyView.
Genetic testing in epithelial ovarian cancer includes both germline and tumor‐testing. This approach often duplicates resources. The current prospective study assessed the feasibility of tumor‐first multigene testing by comparing tumor tissue with germline testing of peripheral blood using an 18‐gene NGS panel in 106 patients.
Elisabeth Spenard, Cristina Mitric, Melanie Care, Tracy L. Stockley, Raymond H. Kim, Jeanna McCuaig, Blaise Clarke, Laura Ranich, Clare Sheen, Sarah E. Ferguson, Liat Hogen, Taymaa May, Marcus Q. Bernardini   +12 more
wiley   +1 more source

The Effect of <i>Pseudomonas putida</i> on the Microbial Community in Casing Soil for the Cultivation of <i>Morchella sextelata</i>. [PDF]

J Fungi (Basel)
Zou R, Zhang Y, Zhang L, Chen M, Xin L, Zhang L.   +5 more
europepmc   +1 more source