Results 201 to 210 of about 11,840,309 (376)

β‐TrCP overexpression enhances cisplatin sensitivity by depleting BRCA1

Molecular Oncology, EarlyView.
Low levels of β‐TrCP (Panel A) allow the accumulation of BRCA1 and CtIP, which facilitate the repair of cisplatin‐induced DNA damage via homologous recombination (HR) and promote tumor cell survival. In contrast, high β‐TrCP expression (Panel B) leads to BRCA1 and CtIP degradation, impairing HR repair, resulting in persistent DNA damage and apoptosis ...
Rocío Jiménez‐Guerrero, Alejandro Belmonte‐Fernández, Mónica González‐Moreno, Laura Rodríguez‐Cordero, Begoña Pérez‐Valderrama, Joaquín Herrero‐Ruíz, Francisco Romero, Carmen Sáez, Miguel Á. Japón   +8 more
wiley   +1 more source

Determination of nitrofuran metabolites in sausage casings and crawfish using LC-Q-Orbitrap HRMS: Method development and validation. [PDF]

Toxicol Rep
Khaled O, Ryad L, Gad N, Eissa F.
europepmc   +1 more source

Quality Assessment and Treatment Method of Wellbore with Casing Damage and Deformation [PDF]

Shuang Liang, Sixi Zhang, Yong Li, Zhong‐Lin Lu, Zhengrong Wu   +4 more
openalex   +1 more source

Unveiling unique protein and phosphorylation signatures in lung adenocarcinomas with and without ALK, EGFR, and KRAS genetic alterations

Molecular Oncology, EarlyView.
Proteomic and phosphoproteomic analyses were performed on lung adenocarcinoma (LUAD) tumors with EGFR, KRAS, or EML4–ALK alterations and wild‐type cases. Distinct protein expression and phosphorylation patterns were identified, especially in EGFR‐mutated tumors. Key altered pathways included vesicle transport and RNA splicing.
Fanni Bugyi, Mirjam Balbisi, Simon Sugár, Lóránd Váncza, Eszter Regős, Ilona Kovalszky, Ibolya Laczó, Tünde Harkó, Gábor Kecskeméti, Zoltán Szabó, Judit Moldvay, László Drahos, Lilla Turiák   +12 more
wiley   +1 more source

Experimental and numerical investigation of endwall flow control through air injection in a contra rotating fan. [PDF]

Sci Rep
Sadoddin M, Khaleghi H.
europepmc   +1 more source

Two-stage, low noise advanced technology fan. 4: Aerodynamic final report [PDF]

A two-stage research fan was tested to provide technology for designing a turbofan engine for an advanced, long range commercial transport having a cruise Mach number of 0.85 -0.9 and a noise level 20 EPNdB below current requirements.
Harley, K. G., Keenan, M. J.
core   +1 more source

Targeting of PTP4A3 overexpression sensitises HGSOC cells towards chemotherapeutic drugs

Molecular Oncology, EarlyView.
In HGSOC with normal KRAS expression, high PTP4A3 expression regulates autophagy activation. Conversely, in HGSOC with high KRAS expression, KRAS dictates autophagy control, and PTP4A3 is not required. When high PTP4A3 expression is inhibited, HGSOC cells are preferentially sensitised towards DNA‐damaging agents.
Ana López‐Garza, David James, Emma Creagh, James T. Murray   +3 more
wiley   +1 more source

Investigation of Eco-Friendly HPAM Polymer Performance and Feasibility for Late-Life EOR in Small, Mature, Waxy Oil Reservoir: A Case Study in Maesoon Oilfield, Thailand. [PDF]

ACS Omega
Charoentanaworakun C, Silla B, Paphatchonchaiyakorn J, Aorak N, Aiemla-Or S.   +4 more
europepmc   +1 more source

Case of Antiphlogistic Treatment [PDF]

BMJ
openaire   +3 more sources

Dynamic characteristics of a variable-mass flexible missile: Dynamics of a two-stage variable-mass flexible rocket [PDF]

The dynamic characteristics of two-stage slender elastic body were investigated. The first stage, containing a solid-fuel rocket, possesses variable mass while the second stage, envisioned as a flexible case, contains packaged instruments of constant ...
Bankovskis, J., Meirovitch, L.
core   +1 more source