Results 351 to 360 of about 24,095,126 (372)
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Caspase-1 activation by Salmonella
Trends in Cell Biology, 2003Salmonella is an interesting example of how the selective pressure of host environments has led to the evolution of sophisticated bacterial virulence mechanisms. This microbe exploits the first-line of defence, the macrophage, as a crucial tool in the initiation of disease.
Harri A. Järveläinen +2 more
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Bioorganic & Medicinal Chemistry, 1999
We have evaluated 619 aspartic ketones with 9 different types of prime-side groups (acyloxymethyl, aryloxymethyl, arylthiomethyl, alkylthiomethyl, acylamino-oxymethyl, sulfonylaminomethyl, alpha-ketoamide, alpha-(1-phenyl-3-trifluoromethyl-pyrazol-5-yl)oxymethyl (PTP), and aliphatic ketones) as inhibitors of caspase-1. The inhibitory behaviors could be
Christine Grinnell +6 more
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We have evaluated 619 aspartic ketones with 9 different types of prime-side groups (acyloxymethyl, aryloxymethyl, arylthiomethyl, alkylthiomethyl, acylamino-oxymethyl, sulfonylaminomethyl, alpha-ketoamide, alpha-(1-phenyl-3-trifluoromethyl-pyrazol-5-yl)oxymethyl (PTP), and aliphatic ketones) as inhibitors of caspase-1. The inhibitory behaviors could be
Christine Grinnell +6 more
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Immunoblotting for Active Caspase-1
2013Immunoblotting for caspase-1 is the gold-standard method of detecting inflammasome activation. In contrast to IL-1β-based readouts, it can be used in an experimental setup independent of de novo gene expression. Here, we present protocols for the preparation and precipitation of supernatant samples containing activated caspase-1 as well as protocols ...
Veit Hornung +4 more
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The intricate biophysical puzzle of caspase-1 activation
Archives of Biochemistry and Biophysics, 2021This review takes a closer look at the structural components of the molecules involved in the processes leading to caspase-1 activation. Interleukins 1β and 18 (IL-1β, IL-18) are well-known proinflammatory cytokines that are produced following cleavage of their respective precursor proteins by the cysteine protease caspase-1.
Nyasha J. Makoni, Michael R. Nichols
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The design and synthesis of sulfonamides as caspase-1 inhibitors
Bioorganic & Medicinal Chemistry Letters, 2004AbstractFor Abstract see ChemInform Abstract in Full Text.
Sheryl Jeanne Hays +9 more
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Sennoside A is a novel inhibitor targeting caspase-1
Food & Function, 2022Sen A decreases caspase-1 activity and P2X7 function, which further leads to NLRP3 and AIM2 inflammasome disassembly and the reduced secretion of IL-1β and IL-18viapyroptosis restraining and NF-κB-involved NLRP3 priming.
Jiasi Wu +8 more
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Caspase-1: an integral regulator of innate immunity
Seminars in Immunopathology, 2015Caspase-1 is a unique cysteine protease playing central roles in innate immunity. Pathogens, stress, and damage signals induce activation of caspase-1, typically mediated by proximity-induced autoproteolysis in multimeric protein complexes called the inflammasome. Active caspase-1 induces secretion of pro-inflammatory cytokines and mediates pyroptosis,
Angela Rösen-Wolff, Stefan Winkler
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Obesity development in caspase-1-deficient mice
International Journal of Obesity, 2013Caspase-1 is a member of the intracellular cysteine protease family that mediates inflammation through the activation of the cytokines interleukin-1β (IL-1β) and interleukin-18 (IL-18). As mice lacking IL-18 become obese and insulin resistant, and both IL-18 and IL-1β have a role in overall energy balance, we sought to determine whether caspase-1 ...
Sarah Faubel +4 more
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Nucleotide Sequence of Equine Caspase-1 cDNA
DNA Sequence, 1999Caspases are a family of cysteine proteases which have important roles in activation of cytokines and in apoptosis. Caspase-1, or interleukin-1 beta converting enzyme (ICE), promotes maturation of interleukin-1 beta (IL-1 beta) and interleukin-18 (IL-18) by proteolytic cleavage of precursor forms to generate biologically active peptides.
David Argyle +4 more
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Quantifying Caspase-1 Activity in Murine Macrophages
2018The caspase-1 protease is a core component of multiprotein inflammasome complexes, which play a critical role in regulating the secretion of mature, bioactive pro-inflammatory cytokines interleukin (IL)-1β and IL-18. The activity of caspase-1 is often measured indirectly, by monitoring cleavage of cellular caspase-1 substrates, processing of caspase-1 ...
Boucher, Dave +3 more
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