Results 361 to 370 of about 24,095,126 (372)

Sevoflurane Combined with ATP Activates Caspase-1 and Triggers Caspase-1-Dependent Pyroptosis in Murine J774 Macrophages

Inflammation, 2012
Sevoflurane is one of the most commonly used volatile anesthetics. Recent studies have shown that sevoflurane plays an important role in modulation of inflammation and immunity. However, little is known about the related molecular mechanisms. This study was designed to investigate the effects and mechanisms of sevoflurane on inflammatory cell death ...
Yue Jin, Shuzhen Chen, Guohao Xie, Hui Li, Xiangming Fang, Shuijin Wu   +5 more
openaire   +2 more sources

Kanamycin activates caspase-1 in NC/Nga mice

Experimental Dermatology, 2011
Abuse of antibiotics to treat children has been associated with an increased risk of the development of inflammatory diseases. The underlying mechanism behind this association still remains to be clarified. Here, we examined the mechanisms behind kanamycin-induced skin inflammation in NC/Nga mice.
Hyun-Ja Jeong, Na-Ra Han, Hyung-Min Kim
openaire   +3 more sources

Is caspase 1 central to activation of interleukin-1?

Joint Bone Spine, 2011
Joint Bone Spine - In Press.Proof corrected by the author Available online since dimanche 3 avril ...
Miriam Wittmann, Michael F. McDermott, Sarah R. Kingsbury   +2 more
openaire   +3 more sources

Role of Caspase‐1 in experimental pneumococcal meningitis: Evidence from pharmacologic Caspase inhibition and Caspase‐1‐deficient mice

Annals of Neurology, 2002
AbstractCaspase 1 plays a pivotal role in generating mature cytokine interleukin‐1β. Interleukin‐1β is implicated as a mediator of pneumococcal meningitis, both in experimental models and in humans. We demonstrated here that (1) Caspase 1 mRNA and protein expression is upregulated in the brain during experimental pneumococcal meningitis, and (2 ...
Richard A. Flavell, Adriano Fontana, Uwe Koedel, Frank Winkler, Hans-Walter Pfister, Barbara Angele   +5 more
openaire   +3 more sources

Immunohistochemical investigation of caspase-1 and effect of caspase-1 inhibitor in delayed neuronal death after transient cerebral ischemia

Brain Research, 2001
The localization of caspase-1 protein, interleukin-1beta (IL-1beta)-converting enzyme, was immunohistochemically examined in the hippocampal CA-1 subfield by a transient occlusion of bilateral common carotid arteries in Mongolian gerbils. Immunoreactivities for caspase-1 were found in microglias, astrocytes, endothelial cells of capillaries and some ...
Mitsuyo Maeda, Yasuhito Hayashi, Masayuki Fukumura, Yuichi Ohashi, Yoshio Ohta, Takashi Yagi, Hiroshi Takagi, Ikuyo Jikihara   +7 more
openaire   +3 more sources

The protease caspase-1: Activation pathways and functions

Biochemical and Biophysical Research Communications
Caspase-1 is one of the main mediators of inflammatory caspases and has become a correspondent with inflammation, cell death, and several inflammatory diseases. In this review, we systematically summarize both original and recent advances in caspase-1 to provide references for a better understanding of the molecular mechanisms in its activation and ...
Hongmin, Zhen, Yumeng, Hu, Xiaoyan, Liu, Guangsen, Fan, Shuna, Zhao   +4 more
openaire   +2 more sources

Differential activation of the inflammasome by caspase-1 adaptors ASC and Ipaf

Nature, 2004
S. Mariathasan, K. Newton, D. Monack, D. Vučić, D. French, Wyne P. Lee, M. Roose-Girma, S. Erickson, V. Dixit   +8 more
semanticscholar   +1 more source

NLRP6 Induces Pyroptosis by Activation of Caspase-1 in Gingival Fibroblasts

Journal of dentistry research, 2018
Wu-Jiang Liu, Jumei Liu, W. Wang, Yunan Wang, X. Ouyang   +4 more
semanticscholar   +1 more source

Caspase-1

2013
openaire   +2 more sources

Caspase-1 Is an Apical Caspase Leading to Caspase-3 Cleavage in the AIM2 Inflammasome Response, Independent of Caspase-8.

Journal of Molecular Biology, 2018
V. Sagulenko, N. Vitak, P. Vajjhala, J. Vince, K. Stacey   +4 more
semanticscholar   +1 more source