Results 311 to 320 of about 24,063,457 (338)

OZONE THERAPY AMELIORATES LPS-INDUCED ACUTE LUNG INJURY IN MICE BY INHIBITING THE NLRP3/ASC/CASPASE-1 AXIS. [PDF]

Shock
Wang P, Zhao Q, Zhu X, Cao S, Williams JP, An J.   +5 more
europepmc   +1 more source

Targeting Hyperglycemic Bone Pre‐Metastatic Niche for Breast Cancer Bone Metastasis Therapy

Advanced Science, EarlyView.
This study reveals that breast cancer creates a hyperglycemic pre‐metastatic niche in bone prior to colonization and amplifies glucose metabolism post‐metastasis. To target this mechanism, a biomimetic enzyme‐engineered nanoplatform that disrupts tumor glycolytic pathways, proposing a therapeutic strategy to inhibit breast cancer bone metastasis by ...
Jianxin Ye, Peng Hu, Rui Zhang, Lei Zhou, Zonghua Luo, Yanan Chen, Shengzhe Ruan, Mengyi Zhu, Huaze Ding, Yike Qian, Yan Xing, Tong Meng, Changping Wang, Dianwen Song   +13 more
wiley   +1 more source

Identification of TMEM71 as a hub NLRP3-related gene suppressing malignant behavior in nasopharyngeal carcinoma via the NLRP3/Caspase-1/GSDMD signaling pathway. [PDF]

Braz J Otorhinolaryngol
Liu D, Liu Y, Cen R.
europepmc   +1 more source

The Immune Microenvironment: New Therapeutic Implications in Organ Fibrosis

Advanced Science, EarlyView.
This review summarizes recent advances in understanding the immune microenvironment's role in fibrosis, focusing on phenotypic/functional alterations of immune cells and their dynamic interactions with other cellular constituents within tissues. The authors further explore therapeutic opportunities and challenges in targeting immune microenvironment ...
Xiangqi Chen, Chuan Wu, Fei Tang, Jingyue Zhou, Li Mo, Yanping Li, Jinhan He   +6 more
wiley   +1 more source

Microglia-derived ADAM9 promote GHRH neurons pyroptosis by Mad2L2-JNK-caspase-1 pathway in subarachnoid hemorrhage. [PDF]

J Neuroinflammation
Mao J, Bao Y, Liu F, Ye Q, Peng J, Nie J, Huang L, Liao Y, Xing Y, Wu D, Wang K, Feng W, Qi S, Pan J, Qiu B.   +14 more
europepmc   +1 more source

Effect of the modified Atkins diet on NLRP3, caspase-1, IL-ιβ, and IL-10 in patients with tetralogy of Fallot undergoing open-heart surgery: A randomized controlled trial. [PDF]

Narra J
Yanuarso PB, Djer MM, Hendarto A, Pudjiadi AH, Rachmadi L, Wibowo H, Advani N, Murni IK, Kekalih A, Sukardi R, Dilawar I, Susanti DS, Supriatna N.   +12 more
europepmc   +1 more source

Clinical significance of caspase-1 in coronary artery lesions in Kawasaki disease and its mechanism of action on vascular smooth muscle cells. [PDF]

Postepy Dermatol Alergol
Yang Y, Sun D, Ma R, Lv M, Wang W.
europepmc   +1 more source

Qilian Jiechang Ning Alleviates TNBS-Induced Ulcerative Colitis in Mice and Segatella copri Outer Membrane Vesicle-Triggered Inflammation in Colon Epithelial Cells via the Caspase-1/11-GSDMD Pathways. [PDF]

J Innate Immun
Hu J, Niu J, Jiang S, Wu Y.
europepmc   +1 more source

[Quercetin suppresses pyroptosis in mouse fibroblasts by inhibiting the NLRP3/caspase-1/GSDMD pathway]. [PDF]

Nan Fang Yi Ke Da Xue Xue Bao
Shu P, Yuan M, Yang K, He W, Liu L.
europepmc   +1 more source