Results 311 to 320 of about 17,150,662 (399)

Neuronal FGF13 Inhibits Mitochondria‐Derived Damage Signals to Prevent Neuroinflammation and Neurodegeneration in a Mouse Model of Parkinson's Disease

Advanced Science, EarlyView.
This study elucidates a novel role of FGF13 in manipulating neuronal fate via mitochondrial transfer. FGF13 is identified as a mitochondria‐stabilizing protein by interacting with mitochondrial proteins. Under stress, the decrease of neuronal FGF13 fails to retain mitochondria within the cytoplasm, leading to the release of damaged mitochondria to ...
Nanshan Song, Xiangxu Wang, Luqing Ha, Lamei Hu, Shuyuan Mei, Yue Liang, Yujie Zhao, Xingyin Yang, Qingyu Zhang, Yuanzhang Zhou, Jianhua Ding, Yan Liu, Qigang Zhou, Feng Han, Gang Hu, Ming Lu   +15 more
wiley   +1 more source

Doxycycline-Induced Apoptosis in <i>Brucella suis</i> S2-Infected HMC3 Cells via Calreticulin Suppression and Activation of the IRE1/Caspase-3 Signaling Pathway. [PDF]

Infect Drug Resist
Wang Z, Yang J, Zhang DE, Qiao X, Yang SL, Wang ZH, Yang Q.   +6 more
europepmc   +1 more source

Targeted Penetrating Motif Engineering of BH3 Mimetic: Harnessing Non‐Canonical Amino Acids for Coinhibition of MCL‐1 and BCL‐xL in Acute Myeloid Leukemia

Advanced Science, EarlyView.
A structure‐guided peptide derived from a non‐canonical amino acid library simultaneously targets MCL‐1 and BCL‐xL to overcome apoptotic resistance in acute myeloid leukemia. Fused with a CXCR4‐binding motif, the engineered peptide exhibits selective intracellular delivery and potent in vivo efficacy, offering a promising therapeutic strategy against ...
Zhe Wang, Ruizhi Lai, Xinpei Wang, Xu Chen, Youjian Zhou, Shengbin Li, Xiaohui Qiu, Zekai Zeng, Jianye Yuan, Jinghuan Mao, Zhidong Chen, Junqing Wang   +11 more
wiley   +1 more source

[Retracted] Naringenin has a chemoprotective effect in MDA‑MB‑231 breast cancer cells via inhibition of caspase‑3 and ‑9 activities. [PDF]

Oncol Lett
Wang R, Wang J, Dong T, Shen J, Gao X, Zhou J.   +5 more
europepmc   +1 more source

Gliclazide protects ionizing radiation-induced intestinal injury in mice by inhibiting oxidative stress and caspase-3. [PDF]

BioTechnologia (Pozn)
Arzani S, Farzipour S, Talebpour Amiri F, Hosseinimehr SJ.   +3 more
europepmc   +1 more source

Caspase-3 promotes genetic instability and carcinogenesis.

Molecules and Cells, 2015
Xinjian Liu, Yu-jun He, Fang Li, Qian Huang, Takamitsu A. Kato, R. Hall, Chuan-Yuan Li   +6 more
semanticscholar   +1 more source

IL-6-Caspase 3 Axis Plays an Important Role in Enteritis Caused by <i>Legionella pneumophila</i> Pulmonary Infection. [PDF]

Microorganisms
Zhao D, Duan X, Zhu L, Fang M, Qin T, Bi Y.   +5 more
europepmc   +1 more source

DFF, a Heterodimeric Protein That Functions Downstream of Caspase-3 to Trigger DNA Fragmentation during Apoptosis

Cell, 1997
X. Liu, Hua Zou, C. Slaughter, Xiaodong Wang   +3 more
semanticscholar   +1 more source

Citronellol Induces Apoptosis via Differential Regulation of Caspase-3, NF-κB, and JAK2 Signaling Pathways in Glioblastoma Cell Line. [PDF]

Food Sci Nutr
Malik MNH, Ali S, Ali A, Alanzi AR, Atif M, Alharbi HA, Wang B, Raza M, Maqbool T, Anjum I, Jahan S, Alshammari SO, Solre GFB.   +12 more
europepmc   +1 more source

Integrin‐Targeted, Activatable Nanophototherapeutics for Immune Modulation: Enhancing Photoimmunotherapy Efficacy in Prostate Cancer Through Macrophage Reprogramming

Aggregate, EarlyView.
To further promote immune activation in the tumor microenvironment, tumor‐selective nanomodulators called RPST@IMQ were proposed, aiming to comprehensively activate endogenous tumor immunity by inducing death of immunogenic cancer cells and remodeling the tumor microenvironment, which demonstrated a great potential for application.
Cheng Zhang, Xiaolan Yin, Lei Hao, Yumei Wang, Linqiang Dou, Qixian Chen, Jun‐Seok Lee, Jingyun Wang, Xiaojun Peng, Juyoung Yoon, Haidong Li   +10 more
wiley   +1 more source