Results 311 to 320 of about 16,798,464 (375)

Memantine abrogates testicular dysfunction induced by risperidone in rats with a potential role of ERK1/2-Nrf2-caspase-3 signaling pathway. [PDF]

Sci Rep
Mohyeldin RH, Sharata EE, Fawzy MA, Attya ME, Welson NN, Rofaeil RR.   +5 more
europepmc   +1 more source

Nasal Delivery of Engineered Exosomes via a Thermo‐Sensitive Hydrogel Depot Reprograms Glial Cells for Spinal Cord Repair

Advanced Science, EarlyView.
Engineered macrophage‐derived exosomes overexpressing GNA12 and GNA13 reprogram glial cells to promote neuroprotection and neural regeneration following SCI. A chitosan‐based thermosensitive hydrogel enables sustained intranasal exosome delivery, bypassing systemic barriers and enhancing therapeutic efficacy.
Yangyang Wang, Jingsong Liu, Pengfei Li, Zhibin Peng, Yubo Zhang, Yishu Liu, Mi Li, Xuqiang Gong, Daqian Liu, Enze Xu, Hongbo Yang, Yuanliang Sun, Yan Xu, Yansong Wang   +13 more
wiley   +1 more source

Extra virgin olive oil mitigates lung injury in necrotizing enterocolitis: Effects on TGFβ1, Caspase-3, and MDA in a neonatal rat model. [PDF]

PLoS One
Tuşat M, Eröz R, Bölükbaş F, Özkan E, Demirtaş MS, Erdal H, Özocak OO.   +6 more
europepmc   +1 more source

Lysosomal Cathepsin S Escape Facilitates Near Infrared Light‐Triggered Pyroptosis Via an Antibody‐Indocyanine Green Conjugate

Advanced Science, EarlyView.
ICAM1 antibody‐bound ICG triggers tumor‐specific, caspase‐1‐independent pyroptosis via CTSS‐mediated GSDMD cleavage, activates antitumor immunity, and synergizes with anti–PD‐1 therapy, offering a non‐apoptotic strategy to overcome resistance in cancer treatment.
Fan Chen, Xue‐Fei Tian, Teng Yang, Yu‐Jie Dai, Da‐Yuan Chen, Hong‐Bo Chen, Takaya Shimura, Xin‐Fang Li, Chu‐Lin Sha, Qing Ji, Jun Cao, Mei‐Yu Fang, Jin‐Biao Shang, Jian‐Min Fang, Ye Lu, Wei‐Hui Zheng, Peng Guo, Wei‐Hong Tan   +17 more
wiley   +1 more source

Protective Effects of Frankincense Oil on Wound Healing: Downregulating Caspase-3 Expression to Facilitate the Transition from the Inflammatory to Proliferative Phase. [PDF]

Pharmaceuticals (Basel)
Venkatesan K, Sivadasan D, Abderrahmen Al Weslati M, Gayasuddin Mouid M, Goyal M, Bansal M, Salama MEM, Azizullah Ghori S, Ahmad F.   +8 more
europepmc   +1 more source

Caspase-1 and -3 are sequentially activated in motor neuron death in Cu,Zn superoxide dismutase-mediated familial amyotrophic lateral sclerosis

, 2000
Piera Pasinelli, Megan K. Houseweart, Robert H. Brown, Don W. Cleveland   +3 more
openalex   +1 more source

KRAS mRNA Spleen‐Targeting Lipid Nanoparticles Synergize with Irinotecan Silicasomes to Robustly Augment the Cancer Immunity Cycle in Pancreatic Cancer

Advanced Science, EarlyView.
To overcome pancreatic cancer's immunosuppressive barriers, this study explores a dual approach: triggering immunogenic tumor cell death at the primary tumor site with irinotecan‐loaded silicasomes and enhancing immune activation in the spleen using LNPs encapsulating tumor antigen mRNA and a TLR7/8 agonist.
Lijia Luo, Xiang Wang, Yu‐Pei Liao, Andre E. Nel   +3 more
wiley   +1 more source

Indole-3-Acetic Acid: Promising Protective Agent Against Methotrexate-Induced Liver Injury via Modulation of TLR4/NF-κB/Caspase-3 Pathway. [PDF]

Pharmaceuticals (Basel)
Alturaif SA, Alhusaini A, Sarawi W, Hasan I, Alsaab J, Ali R, Mohammed R, Alotaibi SS, Almutairi F, Alsaif S, Alsultan E, Aljasas E, Alsanea S.   +12 more
europepmc   +1 more source

High Glucose–Induced Apoptosis in Human Endothelial Cells Is Mediated by Sequential Activations of c-Jun NH ₂ -Terminal Kinase and Caspase-3

, 2000
Feng Ming Ho, Shing‐Hwa Liu, Yook Chin Chia, Por J. Huang, Shoei Yn Lin‐Shiau   +4 more
openalex   +1 more source