Results 331 to 340 of about 17,150,662 (399)

Consumption of Endogenous Caspase-3 Activates Molecular Theranostic Nanoplatform against Inflammation-Induced Profibrotic Positive Feedback in Pulmonary Fibrosis. [PDF]

Adv Sci (Weinh)
Li QL, Chang X, Han YM, Guo ZC, Liu YN, Guo B, Liu C, Yang BR, Fan ZK, Jiang HL, Chang X.   +10 more
europepmc   +1 more source

Caspase‐3 Modulates Regenerative Response After Stroke

Stem Cells, 2014
Wenying Fan, Yiqin Dai, Haochen Xu, Ximin Zhu, Ping Cai, Lixiang Wang, Chungang Sun, Changlong Hu, P. Zheng, Bing-Qiao Zhao   +9 more
semanticscholar   +1 more source

Microglial ApoD‐induced NLRC4 inflammasome activation promotes Alzheimer's disease progression

Animal Models and Experimental Medicine, EarlyView.
We found that NLRC4 inflammasome was activated in microglia releasing IL6 and TNF‐α to impair the hippocampal neural stem cells (NSCs) self‐proliferation. ApoD contributed to activating NLRC4 inflammasome in microglia. Targeting the ApoD provides beneficial effects on NSCs self‐proliferation and mature neurons survival.
Yaliang Yu, Jianzhou Lv, Dan Ma, Ya Han, Yaheng Zhang, Shanlong Wang, Zhitao Wang   +6 more
wiley   +1 more source

[Retracted] Expression of caspase‑3, Bax and Bcl‑2 in hippocampus of rats with diabetes and subarachnoid hemorrhage. [PDF]

Exp Ther Med
He X, Sun J, Huang X.
europepmc   +1 more source

Deficiency of DEK proto‐oncogene alleviates allergic rhinitis by inhibiting RhoA/Ezrin‐mediated mitochondrial fission

Animal Models and Experimental Medicine, EarlyView.
Schematic diagram of the mechanism of DEK regulating RhoA activation Ezrin. Upon house dust mite (HDM) stimulation, HDM‐specific immunoglobulin E (IgE) and inflammatory factors such as interleukin 4 (IL‐4), IL‐5, IL‐13, and eosinophils increased in the nasal mucosa.
Longzhu Dai, Yongde Jin, Jingmei Chai, Jianing Yang, Jiangang Wang, Mu Chen, Liangchang Li, Chongyang Wang, Guanghai Yan   +8 more
wiley   +1 more source

Anti-PD-1 exacerbates bleomycin-induced lung injury in mice via Caspase-3/GSDME-mediated pyroptosis. [PDF]

Cell Death Dis
Wang F, Deng H, Zhou M, Yang Y, Zhou J, Wang Y, Xie X, Lin X, Liu M, Sun G, Zhou C.   +10 more
europepmc   +1 more source

Expression and activity of caspases 1 and 3 in myelodysplastic syndromes

, 2000
Delphine Boudard, Olivier Sordet, C. Vasselon, Valérie Revol, M. F. Bertheas, Damien Freyssenet, Annie Viallet, S PISELLI, Denis Guyotat, Lydia Campos   +9 more
openalex   +1 more source

Targeting signaling pathways in neurodegenerative diseases: Quercetin's cellular and molecular mechanisms for neuroprotection

Animal Models and Experimental Medicine, EarlyView.
Quercetin regulates signaling pathways in neurodegenerative diseases, including NF‐κB, sirtuins, and PI3K/Akt. Studies show quercetin improves symptoms and pathology in neurodegenerative models. The study aims to incorporate laboratory research into practical medical treatment, focusing on quercetin's neuroprotective effects and optimal dosage ...
Md. Rezaul Islam, Md. Ibrahim Khalil Al‐Imran, Mehrukh Zehravi, Sherouk Hussein Sweilam, Mohammad Rakib Mortuza, Jeetendra Kumar Gupta, Thukani Sathanantham Shanmugarajan, Kadirvel Devi, Tanuja Tummala, Mohammed Ali Alshehri, Kalirajan Rajagopal, Mohammed Asiri, Irfan Ahmad, Talha Bin Emran   +13 more
wiley   +1 more source

Establishment of rat model for aspiration pneumonia and potential mechanisms

Animal Models and Experimental Medicine, EarlyView.
Aspiration pneumonia was induced in Sprague Dawley rats by intratracheal instillation of hydrochloric acid (HCl, 1.5 μL/g.wt, pH = 1) followed by lipopolysaccharide (LPS, 20 μg/g.wt) after 1 h. The model reproduced hallmark features of acute lung injury, including histological lung damage, microvascular dysfunction, inflammation, hypoxemia, and ...
Hanbing Hu, Junfeng Chen, Yiru Shao, Yuedong Tang, Yu Dun, Obulkasim Memet, Xuanrong Bao, Jie Shen   +7 more
wiley   +1 more source

Ectromelia virus virulence factor p28 acts upstream of caspase-3 in response to UV light-induced apoptosis

, 2000
David J. Brick, Chris Upton, Aaron A. Minkley, Robert D. Burke   +3 more
openalex   +1 more source