Results 141 to 150 of about 110,976 (256)

Multicenter experience using tofacitinib for treatment of refractory pediatric inflammatory bowel diseases in the United States

open access: yesJournal of Pediatric Gastroenterology and Nutrition, EarlyView.
Abstract Objectives Tofacitinib is a selective Janus kinase (JAK‐1) inhibitor approved for the treatment of ulcerative colitis (UC) in adults. Data is limited in the pediatric population. The aim of this study was to evaluate the efficacy of tofacitinib in pediatric inflammatory bowel disease (IBD).
Denise D. Young   +10 more
wiley   +1 more source

Cassandra tràgica

open access: yesEnrahonar: an international journal of theoretical and practical reason, 1996
Aquest article centra el seu discurs amb la figura de Cassandra, però no para d’insistir de nou sobre aquesta princesa troiana en tant que símbol de la falta de reconeixement públic del discurs femení. S’ analitza com apareix inscrita Cassandra en el context de la tragèdia grega.
openaire   +1 more source

Borrelia and Genital Lichen Sclerosus: A Critical Review of the Evidence

open access: yesJEADV Clinical Practice, EarlyView.
ABSTRACT Background Lichen sclerosus (LSc) is a chronic inflammatory dermatosis that primarily affects the genitalia. Growing evidence supports chronic occlusive urine exposure as the principal pathogenic driver, though other mechanisms, including mechanical irritation, hormonal influences, autoimmunity, and infection, have been proposed.
Liang Zhi Wong   +4 more
wiley   +1 more source

Unique Features of Nasal Airway and Airflow Improvement Post‐Dupilumab: A Computational Cohort Study

open access: yesThe Laryngoscope, EarlyView.
The impact of dupilumab on nasal airway patency and airflow is not uniform. It is more pronounced in the middle and superior, but not inferior meatus. These unique regional changes significantly correlate with and potentially drive the improvement in patient symptoms.
Ahmad Odeh   +12 more
wiley   +1 more source

Scalable treatment algorithm focused on hypertension management for the University of California. [PDF]

open access: yesBMJ Open Qual
Kishore SP   +6 more
europepmc   +1 more source

Genome‐Wide Assessment Reveals Ancestral Differences in Homozygosity Patterns Potentially Linked to Parkinson's Disease Etiology

open access: yesMovement Disorders, EarlyView.
Abstract Background Recessive genetic variation and extended runs of homozygosity (ROHs) may contribute to the unexplained heritability of Parkinson's disease (PD), particularly in diverse and understudied populations. Objective We conducted the first large‐scale, multi‐ancestral investigation of PD to examine the impact of genome‐wide homozygosity on ...
Kathryn Step   +680 more
wiley   +1 more source

Accelerating Medicines Partnership® Parkinson's Disease Proteomics: A Comprehensive Resource for Advancing Parkinson's Disease Research

open access: yesMovement Disorders, EarlyView.
Abstract Background Recent advances in proteomic profiling have enabled its use as a powerful approach in elucidating molecular mechanisms underlying Parkinson's disease, enabling the identification of disease‐associated protein alterations and candidate biomarkers for diagnosis, progression, and therapeutic response.
Victoria J. Dardov   +21 more
wiley   +1 more source

When the Scale Drops: Pathways to Weight Loss in Parkinson's Disease and Future Directions

open access: yesMovement Disorders, EarlyView.
Abstract Although Parkinson's disease (PD) is classically defined by its motor features, non‐motor symptoms exert a substantial and often under‐recognized influence on disease trajectory. Among these, weight loss has long been observed in PD and other neurodegenerative disorders, yet the mechanisms remain incompletely understood.
Ellie D. Gabriel   +6 more
wiley   +1 more source

Table of Contents [PDF]

open access: yes, 2018

core   +1 more source

Oral Health in Amyotrophic Lateral Sclerosis: Feasibility of Oral Screening and Determinants of Poor Outcomes

open access: yesMuscle &Nerve, EarlyView.
People with ALS experience significantly worse oral health than healthy controls, with plaque, gingival inflammation, and bleeding markedly elevated. Lack of dental insurance is the strongest predictor of poor outcomes, while sialorrhea, ethnicity, sex, and dysphagia severity are not independently associated.
Lauren Tabor Gray   +6 more
wiley   +1 more source
humans
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