Results 181 to 190 of about 27,915 (284)

Targeting eIF5A combats breast cancer progression by ClpP‐dependent mitochondrial oxidative stress

open access: yesInterdisciplinary Medicine, EarlyView.
This study identified the eIF5A‐ClpP axis as a key driver of breast cancer progression. Targeting eIF5A suppresses tumor growth by inducing ClpP‐dependent mitochondrial oxidative stress, revealing a novel therapeutic vulnerability. Abstract Breast cancer (BC) poses a persistent global health challenge, necessitating new therapeutic targets.
Jinmei Zhu   +13 more
wiley   +1 more source

FAM107A loss facilitates TTK‐OPTN‐mediated mitophagy to drive docetaxel resistance in castration‐resistant prostate cancer

open access: yesInterdisciplinary Medicine, EarlyView.
In the progression of docetaxel resistance, downregulation of FAM107A releases its transcriptional repression of TTK, leading to TTK upregulation. TTK enhances the interaction and phosphorylation of OPTN. This activates mitophagy in tumor cells, facilitates clearance of damaged mitochondria, reduces intracellular reactive oxygen species accumulation ...
Yishan Zhang   +11 more
wiley   +1 more source

Metrnβ drives sepsis immunosuppression via macrophage reprogramming: A novel prognostic biomarker and therapeutic target

open access: yesInterdisciplinary Medicine, EarlyView.
Metrnβ serves as a novel prognostic biomarker for sepsis and that targeted blockade of the Metrnβ‐c‐Kit axis represents a promising therapeutic strategy for sepsis. Abstract Sepsis is a heterogeneous syndrome critically driven by immunosuppression, yet lacking personalized prognostic markers and therapeutic targets. Here, we provide evidence to support
Xiao Li   +15 more
wiley   +1 more source

Digital and tomographic identification of risk indicators for gingival recession in the mandibular anterior region: A cross‐sectional study

open access: yesJournal of Periodontology, EarlyView.
Abstract Background To assess clinical and anatomical risk indicators for mid‐buccal gingival recessions (GRs) in the mandibular anterior region using digital and tomographic tools. Methods A cross‐sectional study was conducted on 103 patients (618 teeth).
Gonzalo Blasi   +5 more
wiley   +1 more source

Hospital Volume and Post‐Hepatectomy Liver Failure After Major Hepatectomy

open access: yesJournal of Surgical Oncology, EarlyView.
ABSTRACT Background Post‐hepatectomy liver failure (PHLF) following major hepatectomy (MH) increases the risk of morbidity and death. The relationship between institutional MH volume, PHLF, and outcomes is not well characterized. Methods Adults undergoing MH from 2014 to 2021 in the ACS NSQIP hepatectomy‐targeted database were included.
Xane D. Peters   +8 more
wiley   +1 more source

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