Results 211 to 220 of about 2,862,190 (313)

Questionnaire-Based Assessment of Physical Disability in COPD. [PDF]

Int J Chron Obstruct Pulmon Dis
Rogier J, Vivien A, Bolko L, Dury S, Salmon JH, Dormoy V, Ancel J, Deslee G, Perotin JM.   +8 more
europepmc   +1 more source

Loss of E3 Ubiquitin Ligase RINES via CpG Methylation Relieves Suppression of STAT3 and MYC, Facilitating Multiple Tumorigeneses

Advanced Science, EarlyView.
Dysregulated protein modifications drive tumorigenesis. RINES, an E3 ubiquitin ligase, represses tumor cell proliferation and metastasis by facilitating RING domain‐dependent, ubiquitin–proteasome‐mediated degradation of STAT3 and MYC, which consequently restrains cancer stemness and oncogenic progression.
Lili Li, Ka Man Ng, Xingsheng Shu, Xiaoxue Chai, Kai Yau Wong, Gopesh Srivastava, Anthony T.C. Chan, Wai Yee Chan, Qian Tao   +8 more
wiley   +1 more source

In vivo virus-free lineage tracing and live imaging reveal that NeuroD1 does not reprogram microglia into neurons. [PDF]

Elife
Li X, Li Y, Cao Y, Hu N, Yang B, Ouyang P, Jin Y, Gao S, Cao L, Peng B, Rao Y.   +10 more
europepmc   +1 more source

Gm26550 Modulates Learning and Memory by Increasing IGF1 mRNA Expression and Stability in Nrf2−/− Mice

Advanced Science, EarlyView.
The present study shows that Nrf2 directly binds to the Gm26550 promoter, thereby activating Gm26550 transcription and increasing its expression. Mechanistically, Gm26550 promotes IGF1 expression by functionally antagonizing miR‐26a‐5p‐mediated repression and sequestering the RBP KHSRP, thereby enhancing hippocampal neuronal synaptic plasticity and ...
Hongfang Wang, Ziyao Wang, Dongyue Zuo, Zhaowen Su, Bowen Song, Jiamin Gao, Yizhou Zhang, Ruiting Zhao, Linjie Sun, Mengdi Li, Yirui Fan, Dandan Geng, Lei Wang   +12 more
wiley   +1 more source

Combining pro-resolving therapy with cyclosporine A restores immune homeostasis and reduces toxicity in autoimmune bone marrow failure. [PDF]

Cell Rep Med
Grazda R, Bahr A, Nti-Kyeremeh L, Nickerson C, Fredman G, Mayer-Barber KD, MacNamara KC.   +6 more
europepmc   +1 more source

A Molecular Engineering Strategy to Fine‐Tune Phototoxicity of AIE Probes for Super‐Resolution Imaging of Mitochondrial Cristae Dynamics

Advanced Science, EarlyView.
Regulation of molecular packing, phototoxicity, and ROS output of AIE photosensitizers is achieved through carboxylation and alkyl‐chain‐length tuning. The probe designed via this strategy enables super‐resolution visualization of inner‐mitochondrial‐membrane cristae dynamics under controlled oxidative stress, and fluorescence‐lifetime imaging of ...
Kongqi Chen, Mengjie Wang, Chuen Kam, Zhiming Wang, Qinrong Zhang, Sijie Chen   +5 more
wiley   +1 more source

Functional O-specific polysaccharide-specific antibody responses in young children following Shigella infection in Bangladesh. [PDF]

Cell Rep Med
Bernshtein B, Zhiteneva JA, Janardhanan J, Wagh C, Kelly M, Verma S, Faherty CS, Nikolov A, Jung W, Basher SR, Amin MA, Mahamud S, Rajib NH, Chowdhury F, Khan AI, Charles RC, Xu P, Kováč P, Chakraborty S, Kaminski RW, Alter G, Bhuiyan TR, Qadri F, Ryan ET.   +23 more
europepmc   +1 more source

Smart Nanotechnologies for Multimodal Neuromodulation and Brain Interfacing

Advanced Science, EarlyView.
Recent advances in smart nanotechnologies are expanding the toolbox for brain interfacing, from wireless neuromodulation and high‐resolution sensing to targeted delivery within the central nervous system. By combining responsive nanomaterials with bioinspired design, these platforms enable multimodal interactions with neurons and glia, while also ...
Tommaso Curiale, Marie Celine Lefevre, Alessio Carmignani, Maria Cristina Ceccarelli, Matteo Battaglini, Attilio Marino, Gianni Ciofani   +6 more
wiley   +1 more source

VEGFR2-dependent VEGFR3 expression leads to CXCL1/2 and CXCR2 induction in the development of retinal neovascularization. [PDF]

Angiogenesis
Yadavalli CS, Kumar R, Govatati S, Rao GN.   +3 more
europepmc   +1 more source