Results 241 to 250 of about 303,179 (311)

A Soft, Flexible Implant for Wireless Photothermal–Pyroelectric Neurostimulation

Advanced Science, EarlyView.
A replication strategy is used to enlarge the exposed surface area of barium titanate within flexible films with embedded carbon nanotubes, enabling efficient photothermal‐pyroelectric stimulation. Polar crystalline nanosheets show superior performance in guiding neural progenitor cells toward neuronal differentiation.
Jiang Wu, Minmin Mao, Beltzane Garcia Cirera, Hao Ye, Xiangzhong Chen, Josep Puigmartí‐Luis, Ni Qin, Salvador Pané   +7 more
wiley   +1 more source

SMAD4 Palmitoylation Drives a Metabolic‐Transcriptional Circuit to Promote Tumorigenesis and Confers Radiosensitivity in Pancreatic Cancer

Advanced Science, EarlyView.
This study identifies palmitoylation as a novel regulatory modification of SMAD4, mediated by ZDHHC22/APT2. It activates fatty acid synthesis, creating a self‐reinforcing SMAD4–FASN–palmitate feedback loop that drives pancreatic cancer growth and enhances radiotherapy sensitivity.
Yang Wang, Shan Zhang, Junping Bai, Xiaobing Li, Yi Han, Min Ji, Chongyi Jiang, Xiaobei Ge, Tianyu Yu, Yongying Hou, Jun Zhang, Wangting Li, Yiran Song, Jiaying Cai, Yingqun Zhou, Liwei An, Feng Wang   +16 more
wiley   +1 more source

NEK7 Cys298 is important for NLRP3 inflammasome and targetable by dimethyl fumarate. [PDF]

Cell Chem Biol
Zhang Y, Lindner H, So B, Chen Z, Li H, Xu J, Wang J, Xu J, Petre AM, Distefano MD, Núñez G, Lin H.   +11 more
europepmc   +1 more source

Mitochondria and Neuromast Tagging With Fluorescent Gallium‐Triapine Analogues: In Cellulo MP FLIM and Zebrafish Live Imaging

Advanced Science, EarlyView.
Fluorescent BODIPY‐conjugated thiosemicarbazone ligands and their Ga(III), In(III), and Fe(III) complexes, inspired by Triapine, are developed as theranostic agents. Multiphoton FLIM and confocal microscopy in cancer cells and zebrafish reveal real‐time uptake, mitochondrial localisation, and whilst spectroscopic assays indicated preserved complex ...
Megan J. Green, Michael W. Jones, Merissa Saleem, Haobo Ge, Melita Tvardauskaite, Julia Dudzic, Fernando Cortezon‐Tamarit, Rory L. Arrowsmith, Charareh Pourzand, Gabriele Kociock‐Kohn, Nicholas H. Rees, Jonathan R. Dilworth, Stephen Faulkner, Stanley W. Botchway, David Gurevich, Sofia I. Pascu   +15 more
wiley   +1 more source

Long-term rapamycin treatment suppresses IL-17-producing gamma delta T cells and blunts neuroinflammation in aging. [PDF]

PLoS One
Torrent C, Gagliardi C, Fülle N, Antignano I, Bernis ME, Stork M, Bano D, Capasso M, Keane L.   +8 more
europepmc   +1 more source

Inhibition of SIRT7 Overcomes Radioresistance in Pancreatic Neuroendocrine Tumors by Reactivating MEN1 Expression

Advanced Science, EarlyView.
Pancreatic neuroendocrine tumors frequently silence MEN1 through epigenetic mechanisms. Here, SIRT7 recruits DNMT1 to the MEN1 promoter, drives hypermethylation, and enhances DNA repair. Inhibiting SIRT7 restores MEN1, reduces MRN complex abundance, impairs double‐strand break repair, and sensitizes PanNET models to radiation, supporting SIRT7 as a ...
Jianyun Jiang, Yan Wang, Yi Qin, Luohai Chen, Xiaowu Xu, Guixiong Fan, Desheng Jing, Miaoyan Wei, Xianjun Yu, Junfeng Xu, Shunrong Ji, Jie Chen   +11 more
wiley   +1 more source

BPTF is essential for vaccine-induced germinal center B cell responses. [PDF]

J Immunol
Sturtz AJ, Evavold BK, Heidari Rarani Z, Alsoussi WB, Zhou JQ, Matz HC, Muramatsu H, Simkins W, Kumar Malladi S, McIntire KM, Das J, Turner JS, Pardi N, Ellebedy AH.   +13 more
europepmc   +1 more source

Identification of the Annexin A2-interacting domain of pneumococcal PsaA. [PDF]

mSphere
Dey P, Hu Y, Henson F, Kim C, Park N, Seo KS, Thornton JA.   +6 more
europepmc   +1 more source

Characterization of the Ligamentum Mucosum in the Feline and Canine Stifle. [PDF]

Anat Histol Embryol
Ko NT, Woodward EM.
europepmc   +1 more source

Discounting multiple benefits of cat containment by reframing them as trade-offs: Response to Glanville <i>et al.</i> (2025). [PDF]

Anim Welf
Legge S, Woinarski J, Dickman C, Nou T, Dielenberg J.   +4 more
europepmc   +1 more source