Results 281 to 290 of about 636,485 (333)

Microneedle Technology in Psoriasis Management: Mechanistic Insights, Technological Innovation, Clinical Progress, and Challenges

Advanced Healthcare Materials, EarlyView.
This review explores the evolving role of microneedle systems in psoriasis management, highlighting their potential for enhanced drug delivery, diagnosis, and disease monitoring. It also discusses unmet clinical needs for psoriasis management and technical challenges, while outlining strategic directions to advance microneedle integration into routine ...
Fatma Moawad, Yasmine Ruel, Roxane Pouliot, Davide Brambilla   +3 more
wiley   +1 more source

Divergent Sensitization Kinetics to Indoor Allergens in Children: Early Dust Mite Surges vs Delayed Cat Dander Peaks During COVID-19 Lockdowns. [PDF]

J Asthma Allergy
Zhang Y, Fu X, Chen Y, Yang F, Xing Z, Li D, Ren Z, Ren F, Chen Y.   +8 more
europepmc   +1 more source

Dual‐Functional Polyphosphoesters for Gene Delivery: Synergistic Effects of Guanidinium and Hydrophobic Side Chains in Degradable Polymers

Advanced Healthcare Materials, EarlyView.
This study presents guanidinium‐ and indole‐functionalized polyphosphoesters as degradable, non‐viral gene delivery vectors. Through precise tuning of charge density and hydrophobicity, these polymers form stable polyplexes with low toxicity. Remarkably, minor structural changes yield up to 200‐fold differences in transfection efficiency, highlighting ...
Markus Kötzsche, Andreas Dzierza, Jan Egger, Timo Rheinberger, Christin Weilandt, Frederik R. Wurm, Ivo Nischang, Dagmar Fischer, Kalina Peneva   +8 more
wiley   +1 more source

First quantitative assessment of the effects of parasite control in dogs and cats in the UK. [PDF]

Parasit Vectors
Giannelli A, Antonopoulos A, Elsheikha HM, Wright I, Charlier J.   +4 more
europepmc   +1 more source

Kidney Organoids in Drug Development: Integrating Technological Advances and Standardization for Effective Implementation

Advanced Healthcare Materials, EarlyView.
This review examines how emerging enabling technologies enhance the physiological relevance, scalability, and reproducibility of kidney organoids, while advanced analytical approaches support model validation and deepen mechanistic insight into nephrotoxicity.
Helen Kearney, Silvia M. Mihăilă, Lorenzo Moroni, Carlos Mota   +3 more
wiley   +1 more source

Luteolin protects against alcoholic liver injury by restoring NRF2 stability to suppress ACSS2 nuclear accumulation. [PDF]

NPJ Sci Food
Cao L, Lei Q, Dong Y, Meng C, Qi Q, Li L, Liu H, Liu X, Wang M.   +8 more
europepmc   +1 more source

A Synovium‐on‐Chip Platform to Study Multicellular Interactions in Arthritis

Advanced Healthcare Materials, EarlyView.
The Synovium‐on‐Chip comprises a thin microporous PDMS membrane to support co‐culture of fibroblast‐like synoviocytes (FLS), THP‐1‐derived macrophages, and endothelial cells, enabling real‐time analysis of synovial‐vascular interactions. FLS migration through the pores drives endothelial remodeling, while TNF‐α stimulation induces robust inflammatory ...
Laurens R. Spoelstra, Fleur R. Semmekrot, Nuno Araújo‐Gomes, Daniël Wijnperle, Monique M. A. Helsen, Martijn H.J. Van Den Bosch, Loes. I. Segerink, Séverine Le Gac, Marcel Karperien   +8 more
wiley   +1 more source

Mpox virus OPG175 negatively regulates viral replication by controlling Wnt signaling. [PDF]

iScience
Nakata Y, Yamasaki M, Watanabe Y, Uriu K, Hashimoto R, Yamamoto T, Genotype to Phenotype Japan (G2P-Japan) Consortium, Sato K, Saito A, Takayama K.   +9 more
europepmc   +1 more source

Immune activation and response dynamics of human iPSC-derived macrophages in tuberculosis infection models. [PDF]

Clin Transl Immunology
Paasch D, Schevel H, Riehle A, Costa B, Toufaili H, Gehnen T, Dahlmann J, Pavlou A, Neehus AL, Nguyen AHH, Schiering E, Buchegger T, Bustamante J, Hansen G, Kalinke U, Gulbins E, Grassmé H, Lachmann N.   +17 more
europepmc   +1 more source

The First Report on Cat Flea (Ctenocephalides felis), a Zoonotic Haematophagous Insect Infestation in Humans in Bangladesh: A Case Report and Literature Review. [PDF]

Vet Med Sci
Shohana NN, Hossain MS, Labony SS, Ali MH, Alim MA, Nandi AK, Anisuzzaman.   +6 more
europepmc   +1 more source