Results 261 to 270 of about 571,937 (342)

Potassium Sorbate Triggers Kidney Injury via Dysregulated Intercellular Communication: A Study Combining Network Toxicology, Machine Learning, Molecular Docking, and Single‐Cell RNA Sequencing

iMetaMed, EarlyView.
Amyloid precursor protein (APP)‐mediated endothelial‐immune cell crosstalk is a novel mechanism for potassium sorbate‐induced renal injury. Multi‐omics integration (network toxicology, machine learning, scRNA‐seq) uncovers this interaction via APP‐CD74/PTGER2 axes, linking oxidative stress and inflammation to renal damage. ABSTRACT Acute kidney injury (
Yimao Wu, Yalun Liang, Jintao Liang, Gokhan Zengin, Qian Zhang, Meng‐Yao Li   +5 more
wiley   +1 more source

Mimicking DOUGONG brackets orchestrate regulating inflammation and mechanical stimuli for osteochondral regeneration using 3D printing

Interdisciplinary Medicine, EarlyView.
Akermanite scaffolds promote osteogenic differentiation of BMSCs through regulating the PI3K/Akt signaling pathway, and strontium ions enhance the akermanite effects by mediating the cytokine‐cytokine receptor interaction pathway. Thus, the enhancements of osteogenesis in subchondral bone coupled with the chondral‐promoting effects of chondrocytes ...
Bo Li, Yaqi Zhang, Xuerui Zhou, Weiguo Wang, Fan Yang, Qiushi Wei, Leilei Chen, Ziqi Li, Mincong He, Xiaoming He, Shengting Chai, Xiuhong Cao, Rui Wang, Tongmeng Jiang, Chen Wang, Wei He   +15 more
wiley   +1 more source

Frontiers in the Management of Orthopaedic Periprosthetic Joint Infection

Journal of Orthopaedic Research, EarlyView.
ABSTRACT Periprosthetic joint infection (PJI) is a devastating complication of total joint arthroplasty (TJA), one of the most frequently performed surgical procedures worldwide. Management of acute PJI commonly involves debridement, antibiotics, and implant retention (DAIR), though failure rates remain high due to antibiotic‐tolerant biofilms. Chronic
Michael F. Shannon, Victoria R. Wong, Samuelson E. Osifo, Timothy Edwards, Himanshu Rao, Jewelia Rempuszewski, Andrew J. Frear, Shaan Sadhwani, Neel B. Shah, Kenneth L. Urish   +9 more
wiley   +1 more source

Maralixibat for the treatment of severe xanthomas in two children with Alagille syndrome: Case reports

JPGN Reports, EarlyView.
Abstract Alagille syndrome (ALGS) is a rare, autosomal dominant disorder which presents with a broad range of clinical manifestations, including cholestatic pruritus. A unique manifestation of ALGS is the presence of xanthomas in 24%–42% of patients, which can lead to liver transplantation.
Geetanjali Bora, Ruben E. Quiros‐Tejeira, Bernadette Vitola   +2 more
wiley   +1 more source

Challenges and opportunities in mitigating sarcoptic mange in wild South American camelids

The Journal of Wildlife Management, EarlyView.
Wild South American camelids—vicuña and guanaco—face threats from sarcoptic mange, a contagious skin disease linked to severe population declines. Despite its impact, major gaps remain in understanding disease dynamics. This review summarizes current knowledge, identifies key data and management gaps, and outlines urgent actions for effective ...
Alynn M. Martin, Emiliana Isasi‐Catalá, Marília Salgado‐Caxito, Ana Gallegos, Leonardo Hostos‐Olivera, Paulo Colchao‐Claux, Steve Smith, L. Fabian Beltran‐Saavedra, Catherine Dougnac, Camila Germana, Mariana Montoya, Scott Carver, Paul C. Cross, Christian Walzer   +13 more
wiley   +1 more source

Never say never

Journal of Hospital Medicine, EarlyView.
Gurpreet Dhaliwal, Jagmeet Dhingra, Tom Fraser, Leal Herlitz, James Pile   +4 more
wiley   +1 more source

Paediatric Acute Generalised and Localised Exanthematous Pustulosis: A Systematic Review

JEADV Clinical Practice, EarlyView.
Miranda K. Branyiczky, Megan Lowe, Eric McMullen, Shireen Dumont, Narachai Julanon, Vincent Piguet, Cathryn Sibbald   +6 more
wiley   +1 more source