Results 161 to 170 of about 241,016 (306)

Nucleic acid-based therapeutics to restore joint homeostasis in age-related and post-traumatic arthritis. [PDF]

NPJ Biomed Innov
Rai MF, Pham CT, Hou K, Wickline SA, Pan H.   +4 more
europepmc   +1 more source

Prognostic Value of Psoas Major Muscle Volume in Assessing Sarcopenia in Elderly Patients With Rectal Cancer

Annals of Gastroenterological Surgery, EarlyView.
This study investigates the prognostic utility of a novel volumetric indicator—psoas volume index (PVI)—for assessing sarcopenia in elderly rectal cancer patients. Sarcopenia classified by our proposed PVI cut‐off values was associated with poor nutritional and inflammatory status, and patients with low PVI showed significantly worse long‐term outcomes.
Gen Tsujio, Shoichi Manabe, Akio Shiomi, Yusuke Tanaka, Shunsuke Kasai, Tadahiro Kojima, Takahiro Igaki, Yukihiro Mori, Akifumi Notsu   +8 more
wiley   +1 more source

HIF-2<i>α</i>, not angiogenesis, as the therapeutic target in osteoarthritis: A hypothesis. [PDF]

Osteoarthr Cartil Open
Zhang Y, Yang Y.
europepmc   +1 more source

Hepatic Glycogen Storage Diseases in Brazil: A Multicenter Study

American Journal of Medical Genetics Part A, EarlyView.
ABSTRACT To describe clinical and laboratory characteristics, emphasizing the evolution of patients with hepatic glycogen storage diseases (GSDs) followed in Brazilian reference centers. Multicenter, retrospective study involving 13 centers, using RedCap platform. 132 patients were included: 63 (47.8%) GSD type I (56 Ia, 7 Ib), 13 (9.8%) with type III (
Mariana Pena Costa, Alexandre Rodrigues Ferreira, Adriana Teixeira Rodrigues, Rodrigo Rezende Arantes, Thais Costa Nascentes Queiroz, Elisa de Carvalho, Gilda Porta, Irene Kazue Miura, Maria Tereza Galvão Guiotti, Rafaella Karen Sousa Monterlei, Adriana Maria Alves de Tommaso, Gabriel Hessel, Maria Ângela Bellomo‐Brandão, Roberta Vacari de Alcantara, Maria Julia Rodrigues Teixeira de Araujo, Daniela Góis Meneses, Regina Sawamura, Cibele Dantas Ferreira Marques, Lucas Rocha Alvarenga, Marise Helena Cardoso Tofoli, Ana Cristina Vieira de Melo, Jussara Melo de Cerqueira Maia, Leticia Helena Caldas Lopes, Eleonora Druve Tavares Fagundes   +23 more
wiley   +1 more source

α-Ketoglutarate protects against cartilage damage via epigenetically driven metabolic reprogramming in osteoarthritis models. [PDF]

J Clin Invest
Li S, Huang J, Shang T, Lu L, Fan OR, Jin P, Zou X, Cai Z, Lu W, Jia S, Li L, Fang K, Niu F, Li J, Zhao C, Wang Q, Sun R, Shi S, Yin F, Zhang Y, Sun YE, Cui L.   +21 more
europepmc   +1 more source

Compression suture: A method for simulating intervertebral disc degeneration in rats induced by excessive loading

Animal Models and Experimental Medicine, EarlyView.
In the compression suture group, a 5‐mm‐wide tail skin was removed, and then the defect was sutured to apply compressive force to the intervertebral disc. In the sham group, only the 5‐mm‐wide tail skin was removed without a compression suture. Compression suturing triggers apoptosis, inflammatory response, and imbalance of extracellular matrix ...
Xuening Liu, Fengguang Yang, Hefang Xiao, Yanni Duan, Xuewen Kang   +4 more
wiley   +1 more source

Mechanisms of protein degradation in atrophying muscles: What have we learned during the past decade? [PDF]

J Biol Chem
Shemer S.
europepmc   +1 more source

Metabolic and biochemical profiling reveals phenotypic heterogeneity in Zucker diabetic fatty rats

Animal Models and Experimental Medicine, EarlyView.
Genetically uniform Zucker Diabetic Fatty (ZDF) rats spontaneously develop four distinct metabolic phenotypes despite identical housing and diet conditions. Each phenotype exhibits unique biomarker signatures encompassing glucose homeostasis, insulin secretion, polyol pathway activation, oxidative stress, inflammatory cytokines, and neurotrophic ...
Marek Lepáček, Pavol Boďo, Barbora Kaločayová, Marta Šoltésová Prnová   +3 more
wiley   +1 more source

Single‐Injection Multi‐Omics Analysis by Direct Infusion Mass Spectrometry

Angewandte Chemie, EarlyView.
A high‐throughput direct infusion mass spectrometry platform, enabled by gas‐phase ion mobility separation, supports single‐injection analysis of peptides, polar metabolites, and lipids. Coupled with custom software, it identified ∽1,300 proteins and ∽600 metabolites in ∽4.3 minutes per sample, and demonstrated broad utility in macrophage polarization ...
Yuming Jiang, Ivan Salladay‐Perez, Amanda Momenzadeh, Jesús Muñoz‐Estrada, Uktarsh Tripathi, Anthony J. Covarrubias, Jesse G. Meyer   +6 more
wiley   +2 more sources

Acute Biochemical Responses to Competitive Tournament Load in Female Handball Players: Hormonal, Inflammatory and Muscle Damage Markers. [PDF]

Life (Basel)
Pancar Z, Makaracı Y, Gençoğlu C, Karaca B, Ulusal H.   +4 more
europepmc   +1 more source