Results 161 to 170 of about 181,281 (291)

MAPA: A Semantic Network Framework for Functional Module Discovery and Interpretation in Multi‐Omics Data

Advanced Science, EarlyView.
MAPA transforms complex multi‐omics data into biologically coherent functional modules by integrating pathway information with molecular interaction networks. Retrieval‐augmented large language models then generate structured, literature‐informed interpretations.
Yifei Ge, Feifan Zhang, Yijiang Liu, Chao Jiang, Peng Gao, Nguan Soon Tan, Sai Zhang, Yuchen Shen, Qianyi Zhou, Xin Zhou, Xiao Wang, Fangqing Zhao, Chuchu Wang, Xiaotao Shen   +13 more
wiley   +1 more source

Association of Malnutrition, Inflammation, and Residual Kidney Clearance in Peritoneal Dialysis: A Cross-Sectional Analysis. [PDF]

Int J Nephrol
Jeerangsapasuk W, Wichitkul C, Boonkerd T, Wisettorn S, Chatkrailert A.   +4 more
europepmc   +1 more source

The Rate of Protein Catabolism [PDF]

Biochemical Journal, 1913
E P, Cathcart, H H, Green
openaire   +2 more sources

SAT1‐Induced Spermidine Depletion Potentiates Food Allergy

Advanced Science, EarlyView.
Spermidine depletion, driven by upregulated spermidine/spermine N1‐acetyltransferase (SAT1), potentiates food allergy by promoting mast cell degranulation through autophagy suppression. SAT1 physically interacts with the long noncoding RNA Cdk19os to inhibit Atg5 and Atg7, disrupting autophagic flux.
Manman Liu, Beiyu Zhang, Junjuan Wang, Yue Jiang, Shiwen Han, Qianwei Wang, Lingyu Zeng, Jinfeng Wang, Huilian Che   +8 more
wiley   +1 more source

Kynurenine catabolic enzyme KMO regulates HCC growth

Clinical and Translational Medicine, 2022
Zhaopeng Shi, Guifang Gan, Xianfu Gao, Fuxiang Chen, Jun Mi   +4 more
doaj   +1 more source

Musculoskeletal decay and bone-muscle crosstalk during physical disuse: Mechanisms and integrated countermeasures. [PDF]

Exp Physiol
Reyes JM, Hajj-Boutros G, Rouabhia D, Morais J, Salech F, Duque G.   +5 more
europepmc   +1 more source

Temporal Trajectories of the Tau Aggregate Interactome Reveal Stage‐Specific Vulnerabilities in Alzheimer's Disease

Advanced Science, EarlyView.
Tau populations with different aggregation states associate with distinct sets of proteins in the Alzheimer's disease brain. Proteomic discovery combined with single‐molecule analysis in neurons reveals dynamic associations involving proteostasis, metabolism and RNA biology.
Dorothea Böken, Paula Beltran Lobo, Yunzhao Wu, Lyla A. Rowe, Emre Fertan, Cara L. Croft, Maria Jimenez‐Sanchez, Dezerae Cox, David Klenerman   +8 more
wiley   +1 more source

Specificity and longevity of a bacterial interspecies mutual cooperation benefiting organic micropollutant biodegradation. [PDF]

Appl Environ Microbiol
Du S, Horemans B, Springael D.
europepmc   +1 more source

Acid‐Responsive Nanobot‐Integrated Core‐Shell Microneedles Reprogram the Degenerative Annulus Fibrosus Microenvironment Through Epigenetic Suppression of Ferroptosis

Advanced Science, EarlyView.
An acid‐responsive core‐shell microneedle system normalizes the degenerative annulus fibrosus microenvironment by consuming pathological H+, generating O2, and providing NIR‐amplified redox buffering. Mechanistically, it epigenetically suppresses ferroptosis via DNMT3A‐dependent methylation of the ATF3 promoter, relieving ATF3‐mediated repression of ...
Lu Tan, Yan Zheng, Yue Lan, Zhuo Cheng, Siya Wang, Changqing Li, Yanqiu Wang, Minghan Liu   +7 more
wiley   +1 more source

Estrous Sheep Serum-Derived Extracellular Vesicles Deliver Proteins That Modulate Sperm Motility in Sheep. [PDF]

Reprod Domest Anim
Vidal-Garcia C, Neila-Montero M, Díaz-Hernández E, Bóveda P, Picazo-Córdoba CM, Montoro V, García-Álvarez O, Garde JJ, Soler AJ, Iniesta-Cuerda M.   +9 more
europepmc   +1 more source