Results 211 to 220 of about 241,016 (306)

Mechanisms Underlying Cancer Chemoresistance: A Starting Point to Identify New Anticancer Strategies. [PDF]

Int J Mol Sci
Domenicotti C, Marengo B.
europepmc   +1 more source

Polyamine Catabolism [PDF]

, 2020
openaire   +1 more source

Effect of developmental changes on pharmacokinetics of drugs used in the treatment of infant acute lymphoblastic leukaemia—A comprehensive review

British Journal of Clinical Pharmacology, EarlyView.
While the event‐free survival (EFS) of children treated for acute lymphoblastic leukaemia (ALL) has improved greatly in the last decades, the EFS for patients diagnosed with ALL before the age of one is still under 50%. This outcome further decreases when infants have a rearrangement in the gene encoding histone‐lysine N‐methyltransferase 2A (KMT2A ...
Tirsa de Kluis, Leiah J. Brigitha, Lidwien M. Hanff, Alwin D. R. Huitema, Inge M. van der Sluis, Meta H. M. Diekstra   +5 more
wiley   +1 more source

P538: Hyperammonemia in the acute catabolic state

Genetics in Medicine Open
Ghanavi Kumaran, Monica Ramirez, Parul Jayakar, Sajel Kana   +3 more
doaj   +1 more source

Collagen II hydrogel-mediated sustained delivery of lacosamide attenuates cartilage degeneration and pain in osteoarthritis. [PDF]

Bioact Mater
He C, Huang G, Moradi L, Bi J, Yang X, Liu X, Cui X, Varthi A, Wiznia DH, Waxman SG, Fu W, Liu CJ.   +11 more
europepmc   +1 more source

Long‐term impact of Elexacaftor/Tezacaftor/ivacaftor on pulmonary, nutritional and metabolic outcomes in homozygous F508del cystic fibrosis patients: A real‐world cohort study

British Journal of Clinical Pharmacology, EarlyView.
Aim Elexacaftor/tezacaftor/ivacaftor (ETI) has markedly improved cystic fibrosis (CF) outcomes. However, its long‐term impact on nutrition, metabolism and liver health remains underexplored. We assessed 30‐month changes in pulmonary, nutritional, metabolic and inflammatory markers in people with CF (PwCF) homozygous for F508del.
Nicola Perrotta, Luigi Angelo Fiorito, Roberta Vescovo, Anna Virgilio, Giulia Amato, Giuseppe Cimino   +5 more
wiley   +1 more source

Characterization of acetovanillone degradation in wild-type and engineered <i>Rhodococcus aromaticivorans</i> RHA1. [PDF]

Appl Environ Microbiol
Lalande AT, Wolf ME, Robeck LD, Eltis LD.   +3 more
europepmc   +1 more source

Advancing Malic Acid Production of Aspergillus oryzae: Combined Process Optimization and Application of Various Substrates

Biotechnology and Bioengineering, EarlyView.
ABSTRACT In light of climate change and growing resource scarcity, microbial production of organic acids offers a sustainable alternative to fossil‐based chemical synthesis. In this study, malic acid production by Aspergillus oryzae was optimized through cultivation temperature adjustment and biotin supplementation, while organic acid formation from ...
Lukas Hartmann, Anke Neumann, Dirk Holtmann, Björn Vater, Thomas Hahn, Susanne Zibek, Katrin Ochsenreither   +6 more
wiley   +1 more source

Degenerative Disease of Intervertebral Disc: A Narrative Review of Pathogenesis, Clinical Implications and Therapies. [PDF]

Bioengineering (Basel)
Gradisnik L, Kocivnik N, Maver U, Velnar T.   +3 more
europepmc   +1 more source

Establishment of a Single‐Cell Minimal Medium: A Case Study for Microfluidic Cultivation of Corynebacterium glutamicum

Biotechnology and Bioengineering, EarlyView.
Conventional bulk media are often unsuitable for single‐cell cultivation and analysis because they provide excess nutrients or lack essential components. Redesigning the medium allows for controlled, defined growth, enabling the development of a robust minimal medium that supports quantitative and reproducible single‐cell analysis across different ...
Judith Wegmann, Matthias Pesch, Juliane Zwoch, Andreas Schmid, Dietrich Kohlheyer, Alexander Grünberger   +5 more
wiley   +1 more source