Results 121 to 130 of about 149,799 (312)

A Soft, Flexible Implant for Wireless Photothermal–Pyroelectric Neurostimulation

Advanced Science, EarlyView.
A replication strategy is used to enlarge the exposed surface area of barium titanate within flexible films with embedded carbon nanotubes, enabling efficient photothermal‐pyroelectric stimulation. Polar crystalline nanosheets show superior performance in guiding neural progenitor cells toward neuronal differentiation.
Jiang Wu, Minmin Mao, Beltzane Garcia Cirera, Hao Ye, Xiangzhong Chen, Josep Puigmartí‐Luis, Ni Qin, Salvador Pané   +7 more
wiley   +1 more source

HNRNPU K181 Lactylation Drives Cervical Cancer Growth by Upregulating PHGDH and Reprogramming Serine Metabolism

Advanced Science, EarlyView.
Lactate in cervical cancer induces HNRNPU K181 lactylation, opposed by NAA50‐mediated acetylation and suppressed by Pazopanib. This lactylation enhances HNRNPU binding to PHGDH pre‐mRNA exon 1, maintaining exon 1‐containing transcripts and mRNA stability, thereby activating serine metabolism.
Chang Zhang, Qingfei Meng, Hui Jiao, Huixin Liu, Xiangchao Wang, Honglan Zhou, Yishu Wang   +6 more
wiley   +1 more source

A 500 pc volume-limited sample of hot subluminous stars

Astronomy & Astrophysics
We present a quantitative spectroscopic and kinematic analysis of a volume-complete sample of hot subluminous stars within 500 pc of the Sun, assembled using accurate parallax measurements from the Gaia space mission Data Release 3 (DR3).
Dawson H., Dorsch M., Geier S., Munday J., Pritzkuleit M., Heber U., Mattig F., Benitez-Palacios D., Vučković M., Pelisoli I., Deshmukh K., Bhat A., Kufleitner L., Uzundag M., Schaffenroth V., Reindl N., Culpan R., Raddi R., Antunes Amaral L., Istrate A. G., Justham S., Østensen R. H., Telting J. H., Steinmetz T., Rodríguez-Segovia N., Fernandez-Schlosser P., Durán-Reyes A., Arancibia-Rojas E., Latour M., Jones G. T., O’Brien M., Sahu S., Elms A.   +32 more
doaj   +1 more source

A Bioinspired Three‐Dimensional High‐Curvature Nano‐Interface Integrated Microfluidic Chip for Small Extracellular Vesicles Enrichment and Machine Learning‐Assisted Prostate Cancer Precision Diagnosis

Advanced Science, EarlyView.
A biotin‐modified artificial insertion peptide functionalized three‐dimensional high‐curvature‐TiO2 nano‐interface was engineered in a microfluidic chip to improve the isolation efficiency of small extracellular vesicles (sEVs). This chip balanced affinity, releasability, and extendibility, enabling high‐throughput recovery of sEVs for downstream ...
Le Wang, Yizhong Liang, Manan Sulaiman, Jiaqi Du, Ming Jiang, Zhihua Wang, Xu Yu, Li Xu   +7 more
wiley   +1 more source

The origin of B-type runaway stars based on kinematics

Astronomy & Astrophysics
Context. Runaway stars depart their birthplaces with high peculiar velocities. Two mechanisms are commonly invoked to explain their origin, the binary supernova scenario and the dynamical ejection scenario.
Guo Yanjun, Liu Chao, Liu ZhiCun, Li Chunyan, Li Qida, Chen Kun, Han Zhanwen, Chen XueFei   +7 more
doaj   +1 more source

UCHL3 Regulates Subgenomic Flaviviral RNA Condensates to Promote Virus Propagation

Advanced Science, EarlyView.
ABSTRACT Flavivirus subgenomic RNAs (sfRNAs) antagonise antiviral defences, yet how sfRNAs are organized and maintained in cells remains poorly understood. Here we identify ubiquitin C‐terminal hydrolase L3 (UCHL3) as a post‐translational regulator of flavivirus sfRNA stability and function.
Oscar Trejo‐Cerro, Anna Beekmayer‐Dhillon, Qi Wen Teo, Lewis Siu, Ming Yuan Li, Kate J. Heesom, Adán Pinto‐Fernández, Sumana Sanyal   +7 more
wiley   +1 more source

Asteroid characterization using Gaia Data Release 3

Astronomy & Astrophysics
Context. The third Gaia data release (DR3) contains high-precision, sparse-in-time brightness measurements of over 150000 asteroids. Aims. We employed a light-scattering inversion technique to estimate the rotation periods, spin pole orientations, shapes,
MacLennan Eric M., Pentikäinen Hanna, Uvarova Elizaveta, Muinonen Karri, Penttilä Antti, Wilawer Emil, Oszkiewicz Dagmara A., Cellino Alberto, Tanga Paolo, Wang Xiaobin, Virkki Anne   +10 more
doaj   +1 more source

MFPD: A Multiple Fungal Pathogen Detection Pipeline Across Diverse Habitats

Advanced Science, EarlyView.
The MFPD pipeline integrates a comprehensive ITS reference database of fungal pathogens, optimized parameters, and algorithms tailored for both full‐length and subregion sequences that balance accuracy and computational efficiency; it enables high‐throughput, species‐level identification from amplicon sequencing data, supporting large‐scale ...
Yi Shen, Xinrun Yang, Jiabao Yu, Yaozhong Zhang, Tianjie Yang, Yang Gao, Xiaofang Wang, Alexandre Jousset, Waseem Raza, Fang‐Jie Zhao, Qirong Shen, Gaofei Jiang, Zhong Wei, Yangchun Xu   +13 more
wiley   +1 more source

A rotation-based census of blue lurker candidates in open clusters

Astronomy & Astrophysics
Aims. We have compiled a list of blue lurker (BL) candidates in open clusters using the available rotation catalogs. Blue lurkers are rejuvenated main-sequence stars hidden among normal main-sequence stars on color-magnitude diagrams of star clusters. In
Jadhav Vikrant V., Rao Khushboo K., Reggiani Elisabetta   +2 more
doaj   +1 more source

Epigenetic Silencing of RFX7 Defines a Transcriptional Axis Linking Lactate Metabolism to Immune Checkpoint Therapy in Glioblastoma

Advanced Science, EarlyView.
Glioblastoma (GBM) exhibits RFX7 silencing via promoter hypermethylation, which downregulates PIK3IP1 to activate PI3K/AKT signaling, increase lactate accumulation, and enhance histone H4K12 lactylation. This lactylation upregulates PD‐L1/CSF1 expression and drives the immunosuppressive microenvironment formation.
Liying Han, Jinpeng Zhou, Gang Zhu, Fan Chen, Leiyang Li, Wenxing Cui, Fang Sun, Tian Feng, Yue Zhang, Qiang Wang, Shuoyao Ma, Chengxuan Guo, Ziwen Zhang, Kai Wang, Jiahui Wang, Liangbo Wang, Wencong Li, Chenyi Yuan, Haixiao Liu, Liang Wang, Yan Qu   +20 more
wiley   +1 more source