Results 101 to 110 of about 1,051,140 (334)

The atypical KRASQ22K mutation directs TGF‐β response towards partial epithelial‐to‐mesenchymal transition in patient‐derived colorectal cancer tumoroids

open access: yesMolecular Oncology, EarlyView.
TGF‐β has a complex role in cancer, exhibiting both tumor‐suppressive and tumor‐promoting properties. Using a series of differentiated tumoroids, derived from different stages and mutational background of colorectal cancer patients, we replicate this duality of TGF‐β in vitro. Notably, the atypical but highly aggressive KRASQ22K mutation rendered early‐
Theresia Mair   +17 more
wiley   +1 more source

Sunspot Catalogue of the Valencia Observatory (1920-1928) [PDF]

open access: yes, 2014
A sunspot catalogue was maintained by the Astronomical Observatory of Valencia University (Spain) from 1920 to 1928. Here we present a machine-readable version of this catalogue (OV catalog or OVc), including a quality control analysis. Sunspot number (total and hemispheric) and sunspot area series are constructed using this catalogue. The OV catalog's
arxiv   +1 more source

Catalogue of the officers and students of the Kansas State Agricultural College, for the year 1869 [PDF]

open access: yes, 1870
Course catalogs were published under the following titles: Catalogue of the officers and students of the Kansas State Agricultural College, with a brief history of the institution, 1st (1863/4); Annual catalogue of the officers and students of the Kansas
Kansas State Agricultural College
core   +1 more source

Aberrant expression of nuclear prothymosin α contributes to epithelial‐mesenchymal transition in lung cancer

open access: yesMolecular Oncology, EarlyView.
Nuclear prothymosin α inhibits epithelial‐mesenchymal transition (EMT) in lung cancer by increasing Smad7 acetylation and competing with Smad2 for binding to SNAI1, TWIST1, and ZEB1 promoters. In early‐stage cancer, ProT suppresses TGF‐β‐induced EMT, while its loss in the nucleus in late‐stage cancer leads to enhanced EMT and poor prognosis.
Liyun Chen   +12 more
wiley   +1 more source

Body fractions: A physical approach to fraction learning [PDF]

open access: yes, 2011
Many students experience great difficulty understanding the meaning of fractions (Anthony & Walshaw, 2007; Behr, Lesh, Post & Silver, 1983; Davis, Hunting & Pearn, 1993; Lamon, 2007; Verschaffel, Greer & Torbeyns, 2006; Young-Loveridge, Taylor, Hawera ...
Mills, Judith Patricia
core   +3 more sources

A new catalogue of ISM content of normal galaxies

open access: yes, 2003
We have compiled a catalogue of the gas content for a sample of 1916 galaxies, considered to be a fair representation of `normality'. The definition of 'normal' galaxy adopted in this work implies that we have purposely excluded from the catalogue ...
Andreani   +33 more
core   +1 more source

Detecting homologous recombination deficiency for breast cancer through integrative analysis of genomic data

open access: yesMolecular Oncology, EarlyView.
This study develops a semi‐supervised classifier integrating multi‐genomic data (1404 training/5893 validation samples) to improve homologous recombination deficiency (HRD) detection in breast cancer. Our method demonstrates prognostic value and predicts chemotherapy/PARP inhibitor sensitivity in HRD+ tumours.
Rong Zhu   +12 more
wiley   +1 more source

Afrotropical Dolichopodoidae (Diptera) catalogue: Changes and corrections

open access: yesАмурский зоологический журнал, 2020
First addition to the Afrotropical Dolichopodoidae (Diptera) Catalogue (2018) includes new species, new synonyms published in 2018–2020 and a few missing species published earlier. Syntormoneura Curran, 1926 syn. nov.
Igor Ya. Grichanov
doaj   +1 more source

Evaluation of KRAS and NRAS mutations in metastatic colorectal cancer: an 8‐year study of 10 754 patients in Turkey

open access: yesMolecular Oncology, EarlyView.
This nationwide study evaluated KRAS and NRAS mutations in 10 754 Turkish patients with metastatic colorectal cancer. The results revealed a mutation frequency of 51.1%, with 46.6% having KRAS mutations, 4.5% having NRAS mutations, and 48.5% being wild‐type for both.
Gozde Kavgaci   +6 more
wiley   +1 more source

Interpretative ingredients: formulating art and natural history in early modern Brazil [PDF]

open access: yesJournal of Art Historiography, 2014
This essay examines two early modern European texts –– Willem Piso and Georg Marcgraf’s Natural History of 1648 and an anonymous Jesuit manuscript, the Collection of various recipes, of 1766 –– that present an instructive contrast in terms of information
Amy Buono
doaj  

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