Results 181 to 190 of about 1,137,990 (347)

Problems of the Original of the Tibetan <i>Saddharmapuṇḍarīka</i> Registered in the Oldest Extant Catalogue, <i>lDan/lHan dkar ma</i>: Was it the Same as the Sanskrit Text Printed by Kern and Nanjio or by Wogihara and Tsuchida?

, 2020
Asao IWAMATSU
openalex   +2 more sources

Notch2 Directs aTreg Cell Fate toward Immunoregulation or Inflammatory Pyroptosis

Advanced Science, EarlyView.
Schematic illustration showing that the Notch2 intracellular domain (NICD2) facilitates pyroptosis resistance in activated Tregs through the RREB1/Foxo1 signaling pathway. In addition, Notch2‐mediated pyroptosis resistance in activated Tregs promotes immunoregulatory capacity, thereby attenuating Th2‐driven inflammatory responses in allergic rhinitis ...
Yue‐Long Qiao, Shan Xu, You Zou, Rui Yang, Han Zheng, Jia‐Yu Liu, Hui‐Ming Fan, Yuan‐Yuan Zhang, Yong‐Gang Kong, Wo‐Er Jiao, Shi‐Ming Chen   +10 more
wiley   +1 more source

Directions for bringing over seeds and plants, from the East-Indies and other distant countries, in a state of vegetation: : together with a catalogue of such foreign plants as are worthy of being encouraged in our American colonies, for the purposes of medicine, agriculture, and commerce. To which is added, the figure and botanical description of a new sensitive plant, called Dionaea muscipula: or, Venus's fly-trap /

John Ellis
openalex   +4 more sources

BASCULE: bayesian inference and clustering of mutational signatures leveraging biological priors. [PDF]

Genome Biol
Buscaroli E, Sadr A, Bergamin R, Milite S, Villegas Garcia EN, Tasciotti A, Ansuini A, Ramazzotti D, Calonaci N, Caravagna G.   +9 more
europepmc   +1 more source

Lipid Droplet‐Localized Spindle Apparatus Coiled‐Coil Protein 1 Regulates Lipid Droplet Distribution

Advanced Science, EarlyView.
SPDL1‐L, a long isoform of SPDL1, is identified as a bona fide lipid droplet‐associated protein that acts as a dynein adaptor to drive perinuclear clustering of lipid droplets. By linking lipid droplets to the microtubule network, SPDL1‐L extends the function of SPDL1 beyond mitosis and contributes to lipid droplet organization and nuclear remodeling ...
Honggang Su, Huimin Pan, Yaqiang Liu, Wei Wang, Yang Jiao, Yumo Hang, Xiahe Huang, Yong E. Zhang, Yuhang Chen, Mei Ding, Xun Huang   +10 more
wiley   +1 more source

Circ005699 regulates ox-LDL-induced vascular endothelial cell proliferation, autophagy and inflammation by sponging miR-636 and interacting with FTO. [PDF]

Sci Rep
Chen W, Hu J, Chen H, Ye F, Lv K.
europepmc   +1 more source

Targeting WEE1 in ARID1A/TP53 Concurrent Mutant Colorectal Cancer by Exploiting R‐Loop Accumulation and DNA Repair Deficiencies

Advanced Science, EarlyView.
ARID1A, a SWI/SNF complex component, is frequently mutated in colorectal cancer (CRC). CRC with ARID1A/TP53 concurrent mutations shows marked sensitivity to WEE1 inhibition. ARID1A loss induces R‐loop‐mediated replication stress, impairs ATF3 transcription, and amplifies WEE1i‐induced DNA damage, suggesting a promising therapeutic vulnerability ...
Chi Zhang, Yanjing Zhu, Luoyan Ai, Jingyuan Wang, Shan Yu, Yichen Wang, Xiaojing Xu, Mengling Liu, Yiyi Yu, Mengxuan Zhu, Yutong Liu, Zhenghang Xu, Haojie Zhou, Huishan Li, Qihong Huang, Qing Liu, Ke Peng, Tianshu Liu   +17 more
wiley   +1 more source

Structure‐Based Development of Ultra‐Broad‐Spectrum 3C‐Like Protease Inhibitors

Advanced Science, EarlyView.
This study provides an in‐depth analysis of the substrate binding pocket of 3CLpros across all coronavirus species using bioinformatics and structural insights, revealing the critical impact of S2/S4 subsite diversity on the broad‐spectrum activity of approved therapeutics.
Haixia Su, Tianqing Nie, Guofeng Chen, Muya Xiong, Yumin Zhang, Guoqing Wu, Mengyuan You, Hang Xie, Jian He, Yanchao Xiong, Hangchen Hu, Wenfeng Zhao, Minjun Li, Gengfu Xiao, Leike Zhang, Yechun Xu   +15 more
wiley   +1 more source

Evidence-biased medicine? Applying a health equity lens to Sackett's methodological framework. [PDF]

Br J Gen Pract
Mitchell C, Hagan T, Fryer K, Reynolds J, Mawson R, Huang Q, Emery L, Duke B, Patel MG.   +8 more
europepmc   +1 more source

Kaiju index of the GTDB R207 bacterial and archaeal full protein catalogue for representative species

Morillo Sanz Dias, Felipe, Baud, Amelie
openalex   +1 more source