Results 241 to 250 of about 2,878,337 (292)

Programming Gut Microbiome Function Through Cross‐Feeding: From Ecological Mechanisms to Live Biotherapeutics

Advanced Science, EarlyView.
This graphical abstract presents gut microbial cross‐feeding through a Mechanism–Technology–Application framework. It summarizes major resource‐transfer modes, the experimental and computational tools used to establish causality, and potential interventions involving dietary substrates, live biotherapeutic products, and engineered microbes.
Chuankai Sun, Teng Ma, Hao Jin, Zelong Li, Yi Cheng, Jingjin Li, Lai‐Yu Kwok, Zhihong Sun   +7 more
wiley   +1 more source

Local B cell immunity and durable memory after live-attenuated influenza intranasal vaccination of humans. [PDF]

Sci Transl Med
Stacey HD, Garin-Ortega L, Lopez PG, Ramezani-Rad P, Ramirez SI, Faraji F, Bhavsar D, Levi G, Krammer F, Crotty S.   +9 more
europepmc   +1 more source

OsCPK12‐OsATPD1 Module Regulates Photosynthetic Acclimation to Light Stress in Rice

Advanced Science, EarlyView.
OsCPK12 interacts and phosphorylates OsAtpD1 at Ser8 in its transit peptide. This phosphorylation promote its chloroplast translocation, thereby maintaining ATP synthase activity and proton gradient (ΔpH) homeostasis and regulating photosynthetic acclimation, photoprotection, and repair under light stress.
Beifang Wang, Aaron Chan, Yongyi Fan, Yanwu Wang, Pao Xue, Yingxin Zhang, Xiaodeng Zhan, Weixun Wu, Ping Yu, Daibo Chen, Junlin Fu, Yongbo Hong, Xihong Shen, Lianping Sun, Aike Zhu, Shihua Cheng, Qunen Liu, Liyong Cao   +17 more
wiley   +1 more source

PULPO: pipeline of understanding large-scale patterns of oncogenomic signatures. [PDF]

Bioinformatics
Portasany-Rodríguez M, Soria-Alcaide G, Sánchez EG, Ivanova M, Gómez A, Giménez R, Lalchandani J, García-Aguilera G, Alemán-Arteaga S, Saiz-Ladera C, Ramírez-Orellana M, Garcia-Martinez J.   +11 more
europepmc   +1 more source

Uncoupling Type I Interferon Benefits From Inflammatory Toxicity: Transformer‐Prioritized Precision Agonists for Potent and Safer Cancer Immunotherapy

Advanced Science, EarlyView.
A Transformer‐based AI framework, DLINP, screens millions of compounds to identify Co68, a cobalt‐pincer organometallic complex that biases TLR4‐MD2 signaling toward antitumor interferon activation while suppressing inflammatory toxicity through an early TLR4‐SYK‐STAT1 axis.
Xuefei Guo, Yang Zhao, Xianle Rong, Xingyu Chen, Xiao Wang, Tianyi Liu, Yunfei Xie, Yushu Zou, Pingsen Zhao, Qiang Liu, Fuping You   +10 more
wiley   +1 more source

Structural and mechanistic insights into the constitutive Themis-Grb2 complex in T cell signalling. [PDF]

Nat Commun
Clancy DM, Sanz-Sanjuan A, Gilis E, Tougaard P, Velghe I, Van Droogenbroeck Y, Felix J, Bloch Y, Cuadrado ÁF, Merceron R, Schenck S, Vandenabeele P, Brunner JD, Taghon T, Elewaut D, Savvides SN.   +15 more
europepmc   +1 more source

CHST1 Drives Immunotherapy Resistance in Triple‐Negative Breast Cancer by Orchestrating an Immunosuppressive Microenvironment via the NKRF–CCL20–Macrophage Axis

Advanced Science, EarlyView.
Proposed model of CHST1‐associated immune remodeling in triple‐negative breast cancer. In CHST1‐low tumors, greater nuclear accumulation of NKRF is associated with repression of an NF‐κB‐related CCL20 transcriptional program and an immune‐inflamed microenvironment.
Shu‐Hao Jiang, Xiao‐Han Ying, Ruo‐Qing Wang, Qun Zhang, Li Chen, Zhi‐Ming Shao, Jun‐Jie Li   +6 more
wiley   +1 more source

A high-precision catalogue of landslide events in China based on news text mining with large language model. [PDF]

Sci Data
Zhao B, Zhang L, Liu Z, Ma W, Wang J, Sun Q, Luo W, Yu Z, Yuan L.   +8 more
europepmc   +1 more source

Systematic detection of Oxford Nanopore adapter and barcode contamination in GenBank. [PDF]

BMC Genomics
Martino F, Kandathil AJ, Clipman SJ.
europepmc   +1 more source

Loss of erythrocyte arginase-1 impairs vasorelaxation due to endothelial GSNOR overexpression and denitrosylation of G protein subunits. [PDF]

Redox Biol
Gogiraju R, Sun B, Bochenek ML, Wittig I, Rezende F, Lopez M, Wirth A, Zhao W, Böhm EW, Guliani P, Moiko K, Molitor M, Wenzel P, Freichel M, Lurz P, Brandes RP, Schäfer K.   +16 more
europepmc   +1 more source