Results 51 to 60 of about 37,907 (321)

Gauge transformations for higher-order lagrangians [PDF]

open access: yes, 1995
Noether's symmetry transformations for higher-order lagrangians are studied. A characterization of these transformations is presented, which is useful to find gauge transformations for higher-order singular lagrangians. The case of second-order lagrangians is studied in detail. Some examples that illustrate our results are given; in particular, for the
arxiv   +1 more source

Relationship of cognitive decline with glucocerebrosidase activity and amyloid‐beta 42 in DLB and PD

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
Abstract Objective Dementia with Lewy bodies (DLB) and Parkinson's disease (PD) share clinical, pathological, and genetic risk factors, including GBA1 and APOEε4 mutations. Biomarkers associated with the pathways of these mutations, such as glucocerebrosidase enzyme (GCase) activity and amyloid‐beta 42 (Aβ42) levels, may hold potential as predictive ...
Maria Camila Gonzalez   +15 more
wiley   +1 more source

The NADPH oxidase NOX4 regulates redox and metabolic homeostasis preventing HCC progression

open access: yesHepatology, EarlyView., 2022
Loss of NOX4 in HCC tumor cells induces metabolic reprogramming in a Nrf2/MYC‐dependent manner to promote HCC progression. Abstract Background and Aims The NADPH oxidase NOX4 plays a tumor‐suppressor function in HCC. Silencing NOX4 confers higher proliferative and migratory capacity to HCC cells and increases their in vivo tumorigenic potential in ...
Irene Peñuelas‐Haro   +14 more
wiley   +1 more source

La prensa del Trienio Liberal en Cataluña (1820-1823)

open access: yesCuadernos de Ilustración y Romanticismo, 2020
During the Liberal Triennium there is a real explosion of the press throughout Spain that includes various formats, typologies and political cultures. Freedom of the press and intense political debate stimulate the publication of newspapers in towns and ...
Ramon Arnabat Mata
doaj   +1 more source

The impact of modelling choices on modelling outcomes: a spatio-temporal study of the association between COVID-19 spread and environmental conditions in Catalonia (Spain) [PDF]

open access: yesarXiv, 2020
The choices that researchers make while conducting a statistical analysis usually have a notable impact on the results. This fact has become evident in the ongoing research of the association between the environment and the evolution of the COVID-19 pandemic, in light of the hundreds of contradictory studies that have already been published on this ...
arxiv  

A Novel CHMP2B Splicing Variant in Atypical Presentation of Familial Frontotemporal Lobar Degeneration

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
ABSTRACT C‐truncating variants in the charged multivesicular body protein 2B (CHMP2B) gene are a rare cause of frontotemporal lobar degeneration (FTLD), previously identified only in Denmark, Belgium, and China. We report a novel CHMP2B splice‐site variant (c.35‐1G>A) associated with familial FTLD in Spain. The cases were two monozygotic male twins who
Sara Rubio‐Guerra   +17 more
wiley   +1 more source

Clinical, splicing, and functional analysis to classify BRCA2 exon 3 variants: Application of a points‐based ACMG/AMP approach

open access: yesHuman Mutation, Volume 43, Issue 12, Page 1921-1944, December 2022., 2022
Abstract Skipping of BRCA2 exon 3 (∆E3) is a naturally occurring splicing event, complicating clinical classification of variants that may alter ∆E3 expression. This study used multiple evidence types to assess pathogenicity of 85 variants in/near BRCA2 exon 3.
Mads Thomassen   +49 more
wiley   +1 more source

Effects of Pharmacologic and Nonpharmacologic Interventions for the Management of Sleep Problems in People With Fibromyalgia: Systematic Review and Network Meta‐Analysis of Randomized Controlled Trials

open access: yesArthritis Care &Research, EarlyView.
Objective Fibromyalgia is a chronic condition characterized by widespread musculoskeletal pain and fatigue. Almost everyone with fibromyalgia has sleep problems. We aimed to evaluate the effectiveness and safety of current interventions for the management of fibromyalgia‐related sleep problems.
Jemma Hudson   +11 more
wiley   +1 more source

Exposures to pesticides and risk of cancer: Evaluation of recent epidemiological evidence in humans and paths forward

open access: yesInternational Journal of Cancer, Volume 152, Issue 5, Page 879-912, 1 March 2023., 2023
Abstract Knowledge of the role in cancer etiology of environmental exposures as pesticides is a prerequisite for primary prevention. We review 63 epidemiological studies on exposure to pesticides and cancer risk in humans published from 2017 to 2021, with emphasis on new findings, methodological approaches, and gaps in the existing literature.
Haleigh Cavalier   +2 more
wiley   +1 more source

The Polarisation Phenomenon: Case of Spain [PDF]

open access: yesСовременная Европа
The work of the Spanish sociologist Luis Miller is devoted to the study of the phenomenon of polarisation typical of many countries of the modern world ‒ the division of society into two confrontational, or even warring camps.
Sergey M. Khenkin
doaj   +1 more source

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