Results 101 to 110 of about 850,773 (307)

Electrochemical Study of Antioxidant Regeneration Mechanisms – Application in Dermocosmetics

International Journal of Electrochemical Science, 2012
Oxidative stress is associated to the massive generation of reactive oxygen species inducing fast oxidative reactions in chain. To overcome this problem, reasonable supplementations of antioxidants are widely practiced, mostly based on empirical ...
Carole Barus, Fabienne Wetz-Torond, Yves Brunel, Pierre Gros   +3 more
doaj   +1 more source

Effect of Distance from Catalytic Synergy Group to Iron Porphyrin Center on Activity of G-Quadruplex/Hemin DNAzyme

Molecules, 2020
G-quadruplex/Hemin (G4/Hemin) complex has been widely used in biocatalysis and analytical applications. Meanwhile, compared with natural proteinous enzyme, its low catalytic activity is still limiting its applications.
Dehui Qiu, Jingang Mo, Yuan Liu, Jiangyan Zhang, Yongqiang Cheng, Xiaobo Zhang   +5 more
doaj   +1 more source

Synergistic recruitment of UbcH7~Ub and phosphorylated Ubl domain triggers parkin activation [PDF]

, 2018
The E3 ligase parkin ubiquitinates outer mitochondrial membrane proteins during oxidative stress and is linked to early-onset Parkinson’s disease. Parkin is autoinhibited but is activated by the kinase PINK1 that phosphorylates ubiquitin leading to ...
Aguirre, Jacob D., Barber, Kathryn R., Chaugule, Viduth K., Condos, Tara E.C., Dunkerley, Karen M., Freeman, E Aisha, Konermann, Lars, Shaw, Gary S., Walden, Helen, Xiao, Yiming   +9 more
core   +1 more source

PARP inhibition and pharmacological ascorbate demonstrate synergy in castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon, Peter T. Gallagher, Orly I. Richter, Neermala Poudel Neupane, Amy C. Mandigo, Jennifer J. McCann, Emanuela Dylgjeri, Irina Vasilevskaya, Christopher McNair, Channing J. Paller, Wm. Kevin Kelly, Karen E. Knudsen, Matthew J. Schiewer, Ayesha A. Shafi   +13 more
wiley   +1 more source

Research Progress of α-L-Arabinofuranosidase from Microorganisms

Shipin gongye ke-ji
Alpha-L-arabinofuranosidase (α-L-AFase) belongs to glycosyl hydrolases. Its main function is to hydrolyze the arabinose substituents in arabinoxylan and promote the hydrolysis of hemicellulose with other hydrolases synergistically, so as to improve the ...
Jinling CHEN, Jie YANG, Zhen WEI
doaj   +1 more source

Synthesis and Characterization of the k^2-acac-O,O Complex Os_(IV)(acac)_2PhCl and Study of CH Activation with Benzene [PDF]

, 2011
We have synthesized and fully characterized the air-stable complex (κ^2-acac-O,O)2Os^(IV)(Ph)Cl (Cl-1-Ph; acac-O,O = acetylacetonate), which reacts with C_6D_6 to generate Cl-1-Ph-d_5 in high yield and catalyzes the H/D exchange reaction between benzene ...
Cheng, Mu-Jeng, Goddard, William A., III, Mironov, Oleg A., Nielsen, Robert J., Periana, Roy A., Stewart, Timothy, Young, Kenneth J. H.   +6 more
core   +1 more source

Substrate-Induced Self-Assembly of Cooperative Catalysts [PDF]

, 2018
Dissipative self-assembly processes in Nature rely on chemical fuels that activate proteins for assembly through the formation of a noncovalent complex.
Alberts, Ashkenasy, Boekhoven, Boekhoven, Bowne-Anderson, Caplow, Che, Chen, Cheng, Colomer, Dambenieks, Datta, David-Pfeuty, De, Del Grosso, Della Sala, della Sala, Dhiman, Dhiman, England, Fanlo-Virgós, Gruber, Grzybowski, Hao, Hess, Hoffmann, Kariyawasam, Kassem, Köstereli, Li, Maiti, Manea, Mattia, Merindol, Mishra, Pezzato, Pezzato, Ragazzon, Sasaki, Sawczyk, Sorrenti, Tena-Solsona, Tena-Solsona, van Ravensteijn, van Rossum, Wang, Wei, Wood, Zana, Zaupa   +49 more
core   +1 more source

Recurrent cancer‐associated ERBB4 mutations are transforming and confer resistance to targeted therapies

Molecular Oncology, EarlyView.
We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala, Sini Ahonen, Sara Peltola, Aura Tuohisto‐Kokko, Olaya Esparta, Peppi Suominen, Anne Jokilammi, Iman Farahani, Deepankar Chakroborty, Nikol Dibus, Steffen Boettcher, Tomi T. Airenne, Mark S. Johnson, Lisa D. Eli, Klaus Elenius, Kari J. Kurppa   +15 more
wiley   +1 more source

Lignin Degradation by Klebsiella aerogenes TL3 under Anaerobic Conditions

Molecules
Lignin, the largest non-carbohydrate component of lignocellulosic biomass, is also a recalcitrant component of the plant cell wall. While the aerobic degradation mechanism of lignin has been well-documented, the anaerobic degradation mechanism is still ...
Zhuowei Tu, Alei Geng, Yuhua Xiang, Anaiza Zayas-Garriga, Hao Guo, Daochen Zhu, Rongrong Xie, Jianzhong Sun   +7 more
doaj   +1 more source

Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity

Molecular Oncology, EarlyView.
Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung, David Bickel, Lena C. M. Krause, Daria Ezeriņa, Christian Ickes, Julian Wojtachnia, Christine S. Gibhardt, Magdalena Shumanska, Khadija Wahni, Andrea Paluschkiwitz, Julia Malo Pueyo, Ekaterina Baranova, Wim Vranken, Hedwig Stanisz, Ioana Stejerean‐Todoran, Michael P. Schön, Joris Messens, Ivan Bogeski   +17 more
wiley   +1 more source