Results 71 to 80 of about 152,478 (263)

Sophisticated Ensemble Deep Learning Approaches for Multilabel Retinal Disease Classification in Medical Imaging

open access: yesCAAI Transactions on Intelligence Technology, EarlyView.
ABSTRACT This paper introduces a novel ensemble Deep learning (DL)‐based Multi‐Label Retinal Disease Classification (MLRDC) system, known for its high accuracy and efficiency. Utilising a stacking ensemble approach, and integrating DenseNet201, EfficientNetB4, EfficientNetB3 and EfficientNetV2S models, exceptional performance in retinal disease ...
Asghar Amir   +3 more
wiley   +1 more source

Nicotinamide Riboside Supplementation Benefits in Patients With Werner Syndrome: A Double‐Blind Randomized Crossover Placebo‐Controlled Trial

open access: yesAging Cell, EarlyView.
Nicotinamide riboside improved arterial stiffness (cardio–ankle vascular index), reduced skin ulcer area, and showed a trend toward mitigating heel pad thinning in patients with Werner syndrome, with no serious adverse events. Metabolomic analysis revealed a significant decrease in creatinine, suggesting a potential suppression of renal functional ...
Mayumi Shoji   +15 more
wiley   +1 more source

Dietary Selenium Deficiency Accelerates the Onset of Aging‐Related Gut Microbial Changes in Aged Telomere‐Humanized Mice, With Akkermansia muciniphila Being the Most Prominent and Alleviating Selenium Deficiency‐Induced Type 2 Diabetes

open access: yesAging Cell, EarlyView.
Gut Akkermansia muciniphila is enriched by dietary selenium deficiency in aged telomere‐humanized mice and counteracts dietary selenium deficiency‐induced type 2 diabetes. ABSTRACT Previous studies have shown that dietary selenium (Se) deficiency in mice reshapes gut microbiota, exacerbates healthspan deterioration (e.g., type 2 diabetes), and ...
Ying‐Chen Huang   +16 more
wiley   +1 more source

SIRT1 Prevents Lens Epithelial Cell Senescence During Age‐Related Cataract via Regulating p66Shc

open access: yesAging Cell, EarlyView.
Schematic illustration of NMN‐mediated alleviation of age‐related cataract via SIRT1/p66Shc pathway–dependent inhibition of mitochondrial dysfunction and LEC senescence. ABSTRACT Lens epithelial cell (LEC) senescence is one of the key pathological processes of age‐related cataract (ARC) and is associated with oxidative stress, mitochondrial dysfunction,
Huirui Liu   +8 more
wiley   +1 more source

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