Results 81 to 90 of about 152,478 (263)

BubR1 Insufficiency Drives Transcriptomic Alterations and Pathology Associated With Cardiac Aging and Heart Failure

open access: yesAging Cell, EarlyView.
Transcriptomic and cellular analyses of BubR1 hypomorphic hearts reveal disruptions in key pathways and upregulation of markers linked to impaired cardiac structure and function. Comparative transcriptomic analysis shows that BubR1 insufficiency mirrors changes seen in aged and failing hearts. A key finding of this study is that BubR1 levels decline in
Renju Pun   +13 more
wiley   +1 more source

Burden of Oral Corticosteroid Use in Severe Asthma: Challenges and Opportunities

open access: yesAllergy, EarlyView.
ABSTRACT Over the past 70 years, oral corticosteroids (OCS) have played an important role in the management of acute and chronic asthma; however, their use is associated with an increased incidence of adverse events, chronic diseases such as osteoporosis and diabetes, and mortality, as well as increased healthcare resource utilization and costs ...
G. Walter Canonica   +9 more
wiley   +1 more source

Tracking visual outcomes – Follow‐up on patients born preterm with childhood‐onset visual impairment

open access: yesActa Ophthalmologica, EarlyView.
Abstract Purpose Preterm birth is associated with a risk of ocular complications. The primary aim of the study was to evaluate the main cause of visual impairment (VI) in a cohort of preterm born patients who had childhood‐onset VI. The association between health‐related quality of life (HRQoL) and age, cause—and severity of VI and impairment type was ...
Hajer A. Al‐Abaiji   +4 more
wiley   +1 more source

Juvenile idiopathic arthritis during 20 years in Sweden: Characteristics of children, therapy interventions, occurrence of uveitis and ocular complications

open access: yesActa Ophthalmologica, EarlyView.
Abstract Purpose To assess and compare the characteristics, therapy interventions, occurrence of uveitis and ocular complications in children with juvenile idiopathic arthritis (JIA) screened and examined for uveitis in Gothenburg, Sweden, over 20 years.
Pia Lundgren   +7 more
wiley   +1 more source

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