Results 191 to 200 of about 1,796,179 (342)

Marfan Syndrome Associated With Intellectual Disability and Behavioral Anomalies: Further Evidence for the Effect of Compound Heterozygous Variants in FBN1 on Phenotypic Severity

open access: yesAmerican Journal of Medical Genetics Part A, Volume 200, Issue 5, Page 1021-1035, May 2026.
ABSTRACT Marfan syndrome (MFS) is a rare connective tissue disorder characterized by involvement of the cardiovascular, ocular, and musculoskeletal systems. Pathogenic variants in FBN1 cause most of the MFS cases; however, intellectual disability (ID) is rarely observed. A non‐consanguineous Pakistani family with four affected individuals was recruited.
Azmatullah Khan   +4 more
wiley   +1 more source

Multi‐Omics Signatures of Organ Clocks in Biological Aging and Disease: A Conceptual Framework for Organ‐Specific Aging Clocks

open access: yesAging Cell, Volume 25, Issue 5, May 2026.
Organ‐specific aging clocks integrating genomics, epigenomics, transcriptomics, proteomics, and metabolomics offer a more accurate assessment of biological aging than single‐omics approaches. This review proposes a multi‐omics framework emphasizing tissue data, longitudinal study designs, and clinically meaningful training outcomes to advance the ...
Maria Vasileiou   +3 more
wiley   +1 more source

Threat to fixation and vision‐related quality of life in patients with open‐angle glaucoma

open access: yesActa Ophthalmologica, Volume 104, Issue 3, Page 280-287, May 2026.
Abstract Purpose We aimed to investigate the association between overlapping threat to fixation (TTF) and vision‐related quality of life (VRQoL) in patients with manifest open‐angle glaucoma (OAG). Methods Overall, 316 patients with manifest OAG were recruited from the glaucoma outpatient department of Skåne University Hospital, Malmö, Sweden, between ...
Charlotte Almer, Dorothea Peters
wiley   +1 more source

Choroidal vascular hyperpermeability patterns in central serous chorioretinopathy correlate with microperimetry: CERTAIN study report 4

open access: yesActa Ophthalmologica, Volume 104, Issue 3, Page 288-295, May 2026.
Abstract Purpose This report evaluates the association of three distinct leakage patterns of choroidal vascular hyperpermeability (CVH) on indocyanine green angiography (ICGA), previously correlated with disease chronicity, with retinal sensitivity measured by microperimetry in central serous chorioretinopathy (CSC): unifocal indistinct signs of ...
Jennifer M. Chang‐Wolf   +7 more
wiley   +1 more source

Trifocal versus extended depth of focus (EDOF) intraocular lenses after cataract extraction. [PDF]

open access: yesCochrane Database Syst Rev
Tavassoli S   +6 more
europepmc   +1 more source

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