Results 241 to 250 of about 2,605,325 (333)

Obesity‐related early structural alterations in the retina detected by optical coherence tomography

open access: yesDiabetes, Obesity and Metabolism, Volume 27, Issue 6, Page 3262-3273, June 2025.
Abstract Aims This retrospective cross‐sectional study, using retinal spectral‐domain optical coherence tomography (SD‐OCT) scans, investigated obesity‐related structural alterations in the retina. Materials and Methods Ninety‐two eyes of 92 healthy asymptomatic participants were categorized into two groups based on body mass index (BMI) measurements ...
Maide Gözde İnam   +6 more
wiley   +1 more source

Long‐term risk and characteristics of cerebrovascular events after upper body radiotherapy among childhood cancer survivors in the DCCSS‐LATER cohort

open access: yesInternational Journal of Cancer, Volume 156, Issue 10, Page 1858-1872, 15 May 2025.
What's new? Due to the nature of cancer treatments, childhood cancer survivors have an increased risk of serious adverse events later in life. Here, the authors examined the incidence of cerebrovascular events (CVEs) among childhood cancer survivors who had received upper body radiotherapy.
Lisanne C. Verbruggen   +28 more
wiley   +1 more source

The phenotypic spectrum of the Cornelia de Lange‐like “Alazami‐Yuan syndrome”: A case report of the 7th diagnosed individual and review of the literature

open access: yesClinical Case Reports, Volume 13, Issue 5, May 2025.
Key Clinical Message We present a 17‐year‐old female with a childhood clinical diagnosis of Cornelia de Lange Syndrome (CdLS), however later genetic testing identified compound heterozygous variants in TAF6, consistent with AYS. This case report adds to the phenotypic spectrum observed in AYS, and draws connections to transcriptional pathways between ...
Annie Pappas   +6 more
wiley   +1 more source

Healthcare Quality by Specialists Under a Mixed Compensation System: An Empirical Analysis

open access: yesHealth Economics, Volume 34, Issue 5, Page 972-991, May 2025.
ABSTRACT We analyze the effects of a mixed compensation (MC) scheme for specialists on the quality of their healthcare services. We exploit a reform implemented in Quebec (Canada) in 1999. The government introduced a payment mechanism combining a per diem with a reduced fee per clinical service.
Damien Echevin   +2 more
wiley   +1 more source

N‐terminomics and proteomics analysis of Calpain‐2 reveal key proteolytic processing of metabolic and cell adhesion proteins

open access: yesProtein Science, Volume 34, Issue 5, May 2025.
Abstract Aberrant levels of the cysteine protease Calpain‐2 have been linked to neurodegeneration, inflammation, and cancer, yet our understanding of this protease and its substrates remains limited. Systematic studies to identify Calpain‐2 substrates have been largely confined to peptide libraries or in vitro studies, which fail to represent ...
Anjali Kapilan   +13 more
wiley   +1 more source

Evaluation of a New Non‐Mydriatic Handheld Fundus Camera for Fundus Imaging in Cats: A Retrospective Study: 208 Cases (2023–2024)

open access: yesVeterinary Medicine and Science, Volume 11, Issue 3, May 2025.
A non‐mydriatic handheld fundus camera (Aurora, Optomed, Oulu, Finland) was evaluated for feline fundus imaging, providing high‐quality images without pupil dilation. The device demonstrated excellent centration, clarity and visibility in 416 eyes, making it a practical and less stressful alternative for veterinary ophthalmic examinations .
Özlem Şengöz Şirin   +2 more
wiley   +1 more source

Vitrectomy in Small idiopathic MAcuLar hoLe (SMALL) study: Internal limiting membrane peeling versus no peeling

open access: yesActa Ophthalmologica, Volume 103, Issue 3, Page e156-e164, May 2025.
Abstract Purpose To compare vitrectomy with and without internal limiting membrane (ILM) peeling in small idiopathic macular holes. Methods Retrospective multicentre study including consecutive eyes with ≤250 μm idiopathic macular hole treated with vitrectomy. The primary outcome was hole closure rate.
Paola Marolo   +93 more
wiley   +1 more source

Test–retest variability of mesopic microperimetry‐associated parameters in patients with retinitis pigmentosa: REPEAT Study Report No. 2

open access: yesActa Ophthalmologica, Volume 103, Issue 3, Page 313-326, May 2025.
Abstract Purpose Understanding test–retest variability (TRV) of mesopic microperimetry is critical for defining meaningful treatment effects in retinitis pigmentosa (RP) trials. This study uniquely evaluates intra‐ and intervisit TRV and coefficients of repeatability (CoRs) for microperimetry parameters in RP patients with varying best‐corrected visual
Jessica S. Karuntu   +3 more
wiley   +1 more source

Higher risk and earlier onset glaucoma in Cushing's syndrome

open access: yesActa Ophthalmologica, Volume 103, Issue 3, Page e176-e182, May 2025.
Abstract Purpose Glaucoma incidence in patients with endogenous Cushing's syndrome (CS) has never been established. We aim to assess the risk for glaucoma among CS patients compared to controls and determine the age of disease onset. Methods A nationwide retrospective matched‐cohort study of patients with endogenous CS diagnosed between 2000 and 2023 ...
Yael Sharon   +7 more
wiley   +1 more source

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