Results 91 to 100 of about 281,817 (339)

Mutations in the EPHA2 Gene Are a Major Contributor to Inherited Cataracts in South-Eastern Australia

PLoS ONE, 2013
Congenital cataract is the most common cause of treatable visual impairment in children worldwide. Mutations in many different genes lead to congenital cataract.
Alpana Dave, Kate J. Laurie, Sandra E. Staffieri, D. Taranath, D. Mackey, P. Mitchell, Jie-Jin Wang, J. Craig, K. Burdon, Shiwani Sharma   +9 more
semanticscholar   +1 more source

Polymorphisms in ARMS2/HTRA1 and complement genes and age-related macular degeneration in India: findings from the INDEYE study. [PDF]

, 2012
PURPOSE: Association between genetic variants in complement factor H (CFH), factor B (CFB), component 2 (C2), and in the ARMS2/HTRA1 region with age-related macular degeneration (AMD) comes mainly from studies of European ancestry and case-control ...
Chakravarthy, Usha, Fletcher, Astrid E, Nitsch, Dorothea, Nonyane, Bareng AS, Ravindran, Ravilla D, Shanker, Ashwini, Smeeth, Liam, Sundaresan, Periasamy, Vashist, Praveen   +8 more
core   +1 more source

Descriptive Epidemiology From the Myhre Syndrome Foundation Registry: The Value of Self‐Reported Data

American Journal of Medical Genetics Part C: Seminars in Medical Genetics, EarlyView.
ABSTRACT Myhre syndrome is an ultrarare genetic disease characterized by short stature, distinct craniofacial features, cardiovascular and respiratory fibrosis and stenosis, neurodevelopmental delays, autism, intellectual disability, and hearing loss. The natural history of Myhre syndrome is still not fully understood due to a small patient population ...
Mary K. Young, Armelle Pindon, Maggie R. Brand, Kate Wears, Katherine H. Young, Alyssa Mendel, Michael J. Lyons   +6 more
wiley   +1 more source

Diabetes and Cataracts Development—Characteristics, Subtypes and Predictive Modeling Using Machine Learning in Romanian Patients: A Cross-Sectional Study

Medicina
Background and Objectives: Diabetes has become a global epidemic, contributing to significant health challenges due to its complications. Among these, diabetes can affect sight through various mechanisms, emphasizing the importance of early ...
Adriana Ivanescu, Simona Popescu, Adina Braha, Bogdan Timar, Teodora Sorescu, Sandra Lazar, Romulus Timar, Laura Gaita   +7 more
doaj   +1 more source

An Objective Scatter Index Based on Double-Pass Retinal Images of a Point Source to Classify Cataracts

PLoS ONE, 2011
Purpose To propose a new objective scatter index (OSI) based in the analysis of double-pass images of a point source to rank and classify cataract patients. This classification scheme is compared with a current subjective system.
P. Artal, Antonio Benito, G. Pérez, Encarna Alcón, Álvaro De Casas, J. Pujol, J. Marín   +6 more
semanticscholar   +1 more source

The Vietnamese swine as a translational model of invasive ductal carcinoma of the breast

Animal Models and Experimental Medicine, EarlyView.
The flow diagram outlines the chemical induction of breast tumors through a single intraperitoneal dose of MNU. Tumor development was assessed using ultrasound and clinical examination. After 14 weeks, mammary tissue was collected and histologically analyzed to evaluate structural similarities between sows and humans, the carcinogenic potential of MNU,
Claudia Elizabeth Vera‐Tizatl, Arturo Vera‐Hernández, Lorenzo Leija‐Salas, Marco Antonio Vega‐López, María del Carmen Ramírez‐Estudillo, German Isauro Garrido Fariña, Adriana Leticia Vera‐Tizatl   +6 more
wiley   +1 more source

A Rat Treated with Mesenchymal Stem Cells Lives to 44 Months of Age [PDF]

, 2016
There is a growing interest in the potential of mesenchymal stem cells (MSCs) for implementing regenerative medicine. We assessed the effect of intravenous administration of human bone marrow-derived MSC on the life span of a single Sprague-Dawley female
Goya, Rodolfo Gustavo, Mansilla, Eduardo, Roque, Gustavo, Sosa, Yolanda Elena, Tarditti, Adrian   +4 more
core   +1 more source

Evaluation of a modified triple‐combination anesthesia using dexmedetomidine in mice

Animal Models and Experimental Medicine, EarlyView.
Development of a modified ketamine‐free anesthetic (dMMB) using dexmedetomidine. To improve the safety and recovery profile of conventional MMB, we developed dMMB by replacing medetomidine with dexmedetomidine. This ketamine‐free formulation showed comparable anesthetic depth and enhanced thermoregulation, avoiding unnecessary isomers for safer use ...
Masaki Watanabe, Ryosuke Nakanishi, Tomoki Omori, Takeru Sasaki, Atsushi Asano, Nobuya Sasaki   +5 more
wiley   +1 more source

Grading nuclear, cortical and posterior subcapsular cataracts using an objective scatter index measured with a double-pass system

British Journal of Ophthalmology, 2012
Purpose To evaluate objectively intraocular scattering in eyes with nuclear, cortical and posterior subcapsular cataracts by means of an objective scatter index (OSI) obtained from double-pass images.
M. Vilaseca, M. J. Romero, M. Arjona, S. Luque, Juan C. Ondategui, Antoni Salvador, J. Güell, P. Artal, J. Pujol   +8 more
semanticscholar   +1 more source

Implantable Drug Delivery Systems for Skeletal Muscles and Eyes

Advanced NanoBiomed Research, EarlyView.
This review highlights the different types of recent implantable drug delivery systems (IDDS) fabricated for a use with skeletal muscles, and with eyes. It presents the developments already made and the current research directions, showing the evolution of IDDS and their great diversity.
Serge Ostrovidov, Murugan Ramalingam, Hongkai Wu, Toshinori Fujie, Yukinari Nakamura, Takeshi Hori, Yuji Nashimoto, Xuetao Shi, Hirokazu Kaji   +8 more
wiley   +1 more source