Results 151 to 160 of about 110,885 (306)

The effect of repeated eye examinations and breeding advice on the prevalence and incidence of cataracts and progressive retinal atrophy in German dachshunds over a 13-year period [PDF]

open access: yes, 2017
Bedford   +29 more
core   +1 more source

Nicotinamide Riboside Supplementation Benefits in Patients With Werner Syndrome: A Double‐Blind Randomized Crossover Placebo‐Controlled Trial

open access: yesAging Cell, EarlyView.
Nicotinamide riboside improved arterial stiffness (cardio–ankle vascular index), reduced skin ulcer area, and showed a trend toward mitigating heel pad thinning in patients with Werner syndrome, with no serious adverse events. Metabolomic analysis revealed a significant decrease in creatinine, suggesting a potential suppression of renal functional ...
Mayumi Shoji   +15 more
wiley   +1 more source

Dietary Selenium Deficiency Accelerates the Onset of Aging‐Related Gut Microbial Changes in Aged Telomere‐Humanized Mice, With Akkermansia muciniphila Being the Most Prominent and Alleviating Selenium Deficiency‐Induced Type 2 Diabetes

open access: yesAging Cell, EarlyView.
Gut Akkermansia muciniphila is enriched by dietary selenium deficiency in aged telomere‐humanized mice and counteracts dietary selenium deficiency‐induced type 2 diabetes. ABSTRACT Previous studies have shown that dietary selenium (Se) deficiency in mice reshapes gut microbiota, exacerbates healthspan deterioration (e.g., type 2 diabetes), and ...
Ying‐Chen Huang   +16 more
wiley   +1 more source

Cataract production in mice by heavy charged particles [PDF]

open access: yes
The cataractogenic effects of heavy charged particles are evaluated in mice in relation to dose and ionization density. The relative biological effectiveness in relation to linear energy transfer for various particles is considered.
Ainsworth, E. J.   +3 more
core   +1 more source

SIRT1 Prevents Lens Epithelial Cell Senescence During Age‐Related Cataract via Regulating p66Shc

open access: yesAging Cell, EarlyView.
Schematic illustration of NMN‐mediated alleviation of age‐related cataract via SIRT1/p66Shc pathway–dependent inhibition of mitochondrial dysfunction and LEC senescence. ABSTRACT Lens epithelial cell (LEC) senescence is one of the key pathological processes of age‐related cataract (ARC) and is associated with oxidative stress, mitochondrial dysfunction,
Huirui Liu   +8 more
wiley   +1 more source

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