Results 81 to 90 of about 281,817 (339)

Alpinetin Nanoparticles Alleviate Optic Nerve Injury Induced by Acute Glaucoma via LRP1‐PPARγ Mediated Regulation of Microglial Lipid Metabolism

Advanced Science, EarlyView.
Microglial lipid metabolic dysfunction drives neurodegeneration in glaucoma. We found loss of LRP1 causes lipid accumulation and inflammation. We developed alpinetin‐loaded nanoparticles (AlpNPs) that bind LRP1, activate the PPARγ‐LXRα‐ABCA1 pathway to restore lipid homeostasis, promote an anti‐inflammatory phenotype, and protect retinal ganglion cells,
Miao Wei, Yujia Huo, Jingchang Yuan, Xiao Fan, Xiaochen Wang, Sisi Tan, Xi Gao, Ruotong Ouyang, Hong Li   +8 more
wiley   +1 more source

A novel mutation of p.F32I in GJA8 in human dominant congenital cataracts [PDF]

International Journal of Ophthalmology, 2016
AIM: To identify a causative mutation in a three-generation family with autosomal dominant congenital total cataract and dissect the molecular consequence of the identified mutation.
Feng-Tao Dang, Fa-Yu Yang, Ye-Qin Yang, Xiang-Lian Ge, Ding Chen, Liu Zhang, Xin-Ping Yu, Feng Gu, Yi-Hua Zhu   +8 more
doaj   +1 more source

Primary radiotherapy in progressive optic nerve sheath meningiomas: a long-term follow-up study [PDF]

, 2010
Background/aims: To report the outcome of primary radiotherapy in patients with progressive optic nerve sheath meningioma (ONSM). Methods: The clinical records of all patients were reviewed in a retrospective, observational, multicentre study.
Blank, L., Geskus, R., Mourits, M., Nowak, P., Rootman, J., Saeed, P., Selva-Nayagam, D., Weis, E., Wolbers, J.   +8 more
core   +5 more sources

Hot‐Pressing Annealing‐Induced Light Utilization Enhancement and Crystallinity Optimization Enable High‐Performance Narrowband Ultraviolet Photodetectors for Real‐Time Ultraviolet Radiation Monitors

Advanced Science, EarlyView.
By utilizing a hot‐pressing (HP) annealing strategy, Cs3Cu2I5 films with larger grains vertically spanning the entire thickness are fabricated. Because HP annealing enhances light utilization and charge transport in Cs3Cu2I5/GaN heterojunction, the HP device achieves superior detection performance while maintaining narrowband photoresponse to UVA/UVB ...
Jingli Ma, Junhao Zhu, Conghui Dun, Hao Wang, Bangbang Yang, Mengyao Zhang, Lejin Li, Huifang Ji, Yanbing Han, Ying Liu, Di Wu, Xinjian Li, Chongxin Shan, Zhifeng Shi   +13 more
wiley   +1 more source

Connexin Mutants and Cataracts

Frontiers in Pharmacology, 2013
The lens is a multicellular, but avascular tissue that must stay transparent to allow normal transmission of light and focusing of it on the retina. Damage to lens cells and/or proteins can cause cataracts, opacities that disrupt these processes.
E. Beyer, L. Ebihara, V. M. Berthoud
semanticscholar   +1 more source

Mainstream Artificial Intelligence Technologies in Contemporary Ophthalmology

Advanced Intelligent Systems, EarlyView.
This review explores the latest artificial intelligence (AI) technologies in ophthalmology, focusing on four key data types: medical imaging, electronic health records, robotic‐assisted surgery, and genomics. It examines the structural features, use cases, clinical goals, and evaluation metrics of various AI algorithms, while also introducing emerging ...
Shiqi Yin, Lei Wang, Shanjun Wu, Jiewei Jiang, Wei Qiang, Yangyang Wang, Shihong Wang, Yi Shao, Wei Chen, Zhongwen Li   +9 more
wiley   +1 more source

A novel dominant mutation in CRYAB gene leading to a severe phenotype with childhood onset

Molecular Genetics & Genomic Medicine, 2020
Background αB‐crystallin is a promiscuous protein involved in numerous cell functions. Mutations in CRYAB have been found in patients with different pathological phenotypes that are not properly understood.
Ana T. Marcos, Diego Amorós, Beatriz Muñoz-Cabello, Francisco Galán, Eloy Rivas Infante, Luis Alcaraz‐Mas, José M. Navarro‐Pando   +6 more
doaj   +1 more source

Nance‐Horan Syndrome: Further Delineation of the Affected Male and the Female Carrier Phenotypes

American Journal of Medical Genetics Part A, EarlyView.
ABSTRACT Nance‐Horan syndrome (NHS; OMIM 302350) is a rare, X‐linked syndrome characterized by bilateral congenital cataracts leading to profound vision loss, specific dental anomalies including characteristic screwdriver blade‐shaped incisors, facial anomalies, and intellectual disability.
Maria K. Haanpää, Chad R. Haldeman‐Englert, Marja Hietala, Melisa S. Tanverdi, Patrick P. Koty, Diana Brightman, Eniolami Dosunmu, Shailja Tibrewal, Savleen Kaur, Anupriya Kaur, Raj Kumar Verma, Alejandra G. de Alba Campomanes, Virginia Utz, Anne M. Slavotinek, Cynthia Curry   +14 more
wiley   +1 more source

Elevated Frequency of Cataracts in Birds from Chernobyl

PLoS ONE, 2013
Background Radiation cataracts develop as a consequence of the effects of ionizing radiation on the development of the lens of the eye with an opaque lens reducing or eliminating the ability to see.
Timothy A Mousseau, A. Møller
semanticscholar   +1 more source

Non‐RASopathy Genetic Syndromes Identified as the Molecular Cause of Disease in Patients Previously Diagnosed With Noonan Syndrome

American Journal of Medical Genetics Part A, EarlyView.
ABSTRACT Noonan Syndrome (NS) is a clinically and genetically heterogeneous condition characterized by typical facial dysmorphisms, short stature, congenital heart defects, and developmental delays. While variants in genes such as PTPN11, SOS1, and RAF1 account for most genetically confirmed cases, diagnosis is challenging due to phenotypic overlap ...
Gabriela Jeesoo Kim, Alexsandra Christianne Malaquias, Debora Romeo Bertola, Raissa Carneiro Rezende, Laurana De Polli Cellin, Lucas Vieira Lacerda Pires, Ana Maria Santillan‐Vasconez, Antônio Marcondes Lerario, Renata da Cunha Scalco, Alexander Augusto de Lima Jorge   +9 more
wiley   +1 more source