Results 21 to 30 of about 137,294 (265)
Indian Journal of Community MedicineBackground: People with diabetes need extensive self-management support, medications, regular screening for and treatment of possible complications and comorbidities, all of which can increase out-of-pocket (OOP) costs in patients and their families ...
Lingareddy Prathyusha +3 more
doaj +1 more source
Molecular Oncology, EarlyView.The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington +10 more
wiley +1 more source
Molecular characterization of covRS mutations in M1UK Streptococcus pyogenes
FEBS Open Bio, EarlyView.Group A Streptococcus (GAS) acquires covRS mutations driving a hypervirulent bacterial state, frequently associated with invasive disease‐like necrotizing fasciitis. We demonstrate that the newly emerged M1UK GAS lineage can also acquire these mutations.
Jarrad Pritchard +12 more
wiley +1 more source
FireTimely and efficient evacuation is crucial for tunnel fire safety. Previous studies often assumed fixed vehicle spacing and vehicle type ratios, which did not reflect real traffic conditions.
Dingli Liu +7 more
doaj +1 more source
In silico and in vitro exploration of a tyrosinase for biocatalytic production of catechols
FEBS Open Bio, EarlyView.Tyrosinase from Ralstonia pseudosolanacearum is a promising biocatalyst for producing valuable catechols from monophenol substrates. This tyrosinase is uniquely suited to this due to its high monophenolase : diphenolase ratio. We combined in silico docking and in vivo kinetic characterisation of this tyrosinase with 11 industrially relevant monophenols,
James Britton +6 more
wiley +1 more source
Positive Affect is Associated with Better Physical Function in Early Rheumatoid Arthritis
Arthritis Care &Research, Accepted Article.Objective This study examined the association between positive affect and physical function in individuals with early rheumatoid arthritis (RA). Methods We analyzed baseline data from 129 adults with early RA (persistent joint symptoms for ≤ 24 months) and active disease enrolled in the Central Pain in RA 2 (CPIRA‐2) study.
Burcu Aydemir +9 more
wiley +1 more source
Superintelligence Skepticism as a Political Tool
Information, 2018 This paper explores the potential for skepticism about artificial superintelligence to be used as a tool for political ends. Superintelligence is AI that is much smarter than humans.
Seth D. Baum
doaj +1 more source
Dynamic Reliability of Continuous Rigid-Frame Bridges under Stochastic Moving Vehicle Loads
Shock and Vibration, 2020 The current volume of freight traffic has increased significantly during the past decades, impacted by the fast development of the national transportation market.
Naiwei Lu +5 more
doaj +1 more source
What Do Large Language Models Know About Materials?
Advanced Engineering Materials, EarlyView.If large language models (LLMs) are to be used inside the material discovery and engineering process, they must be benchmarked for the accurateness of intrinsic material knowledge. The current work introduces 1) a reasoning process through the processing–structure–property–performance chain and 2) a tool for benchmarking knowledge of LLMs concerning ...
Adrian Ehrenhofer +2 more
wiley +1 more source
Countering Superintelligence Misinformation
Information, 2018 Superintelligence is a potential type of future artificial intelligence (AI) that is significantly more intelligent than humans in all major respects.
Seth D. Baum
doaj +1 more source